Search results for "modifier"
showing 10 items of 41 documents
Spinopelvic changes based on the simplified SRS-Schwab adult spinal deformity classification: relationships with disability and health-related qualit…
2018
Study design Cross-sectional, observational study. Objective To study the occurrence of sagittal malalignment, the adaptability of a simplified sagittal modifiers grading of the Scoliosis Research Society (SRS)-Schwab adult spinal deformity (ASD) classification, and the deformity-specific SRS questionnaire version 30 (SRS-30) in an unselected adult cohort with symptomatic degenerative spinal disorders. Summary of background data The sagittal modifiers of the SRS-Schwab ASD classification correlate with health-related quality of life (HRQoL) measures in patients with ASD. The deformities and disabilities caused by sagittal malalignment in patients with common degenerative spinal disorders of…
Interrogator intonation and memory encoding performance.
2019
Based on recent findings that interrogator intonation can enhance interrogative suggestibility during recall phases, the present study tested influences of interrogator intonation on memory performance even as early as at the encoding stage. We experimentally manipulated interrogator intonation during encoding of a story to be recalled in immediate and delayed subsequent memory tests (Experiment 1, N = 50). As expected, a symmetrically structuring vs. an isolating-emphasizing speaking style generally increased the amount of freely recalled details. In a more fine-grained experiment (N = 50), we additionally manipulated emphasized story details and tested recall rates for peripheral, neutral…
Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants
2019
Purpose: To assess the contribution of rare variants in the genetic background toward variability of neurodevelopmental phenotypes in individuals with rare copy-number variants (CNVs) and gene-disruptive variants. Methods: We analyzed quantitative clinical information, exome sequencing, and microarray data from 757 probands and 233 parents and siblings who carry disease-associated variants. Results: The number of rare likely deleterious variants in functionally intolerant genes (“other hits”) correlated with expression of neurodevelopmental phenotypes in probands with 16p12.1 deletion (n=23, p=0.004) and in autism probands carrying gene-disruptive variants (n=184, p=0.03) compared with thei…
Therapy of Peritoneal Murine Cancer with Biological Response Modifiers
1985
We have used a murine renal adenocarcinoma of spontaneous origin (Renca) inplanted in the peritoneal cavity to study the therapeutic potential of biological response modifiers (BRMs) used alone or in conjunction with chemotherapy. This tumor model is therapeutically challenging since following intraperitoneal (i.p.) injection, the tumor grows progressively with hemorrhagic ascites, abdominal metastases to lymph nodes, liver, spleen, most serous membranes, and, in some animals, metastases to extra-abdominal sites (lungs). In the absence of therapy, death invariably occurs within 36 +/- 2 days. The tumor is efficiently lysed in 4 hours by peritoneal cells isolated from mice treated with BRMs.…
Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients.
2006
Small ubiquitin-related modifier (SUMO4), located in IDDM5, has been identified as a potential susceptibility gene for type 1 diabetes mellitus (T1DM). The novel polymorphism M55V, causing an amino acid change in the evolutionarily conserved met55 residue has been shown to activate the nuclear factor kappaB (NF-kappaB), hence the suspected role of SUMO4 in the pathogenicity of T1DM. The M55V polymorphism has been shown to be associated with susceptibility to T1DM in Asians, but not in Caucasians. Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of T1DM and SUMO4 M55V has not been studied in LADA to date. The current study aims to test whether Latvians are similar to …
Junctophilin-1 is a modifier gene of GDAP1-related Charcot-Marie-Tooth disease.
2014
Mutations in the GDAP1 gene cause different forms of Charcot-Marie-Tooth (CMT) disease, and the primary clinical expression of this disease is markedly variable in the dominant inheritance form (CMT type 2K; CMT2K), in which carriers of the GDAP1 p.R120W mutation can display a wide range of clinical severity. We investigated the JPH1 gene as a genetic modifier of clinical expression variability because junctophilin-1 (JPH1) is a good positional and functional candidate. We demonstrated that the JPH1-GDAP1 cluster forms a paralogon and is conserved in vertebrates. Moreover, both proteins play a role in Ca(2+) homeostasis, and we demonstrated that JPH1 is able to restore the store-operated Ca…
Effect of heating of organo-montmorillonites under different atmospheres
2009
Abstract We studied the influence of heating on the behaviour of two organo-montmorillonites paying particular attention to the possible degradation effects of the organic modifier under different atmospheres. Hoffmann elimination and anucleophilic substitution on the nitrogen led to rapid degradation of the modifier. As confirmed by deconvoluted FTIR spectra, the presence of oxygen accelerated the degradation rate. The degradation products of the modifier (α-olefins transforming into various carboxyl compounds if oxygen is present) initially increased the basal spacing, followed by a collapse of the particle layers when the decomposition products migrated toward the surface and eventually …
Photo-stabilization of biopolymers-based nanocomposites with UV-modified layered silicates
2020
Abstract Eco-friendly in-situ stabilised biopolymer nanocomposites based on polyamide 11 (PA11) and polylactic acid (PLA) were prepared by melt mixing in the presence of a modified organo-montmorillonite clay containing a chemically-bound hindered amine UV-stabilising function, [(UV)OM-MMt]. Characterisation of the newly synthesised organo-modifier containing the reactive hindered amine (HAS) UV-stabilising function [(UV)OM] has confirmed a successful synthesis. The (UV)OM was then introduced into NaMMt through ion exchange reaction to prepare the UV stabiliser-bound organo-modified-MMt, [(UV)OM-MMt]. The in-situ stabilised PA11- and PLA- nanocomposites (PA11-(UV)OM-MMt and PLA-(UV)OM-MMt) …
Multi-Alkenylsilsesquioxanes as Comonomers and Active Species Modifiers of Metallocene Catalyst in Copolymerization with Ethylene.
2018
The copolymers of ethylene (E) with open-caged iso-butyl-substituted tri-alkenyl-silsesquioxanes (POSS-6-3 and POSS-10-3) and phenyl-substituted tetra-alkenyl-silsesquioxane (POSS-10-4) were synthesized by copolymerization over the ansa-metallocene catalyst. The influence of the kind of silsesquioxane and of the copolymerization conditions on the reaction performance and on the properties of the copolymers was studied. In the case of copolymerization of E/POSS-6-3, the positive comonomer effect was observed, which was associated with the influence of POSS-6-3 on transformation of the bimetallic ion pair to the active catalytic species. Functionality of silsesquioxanes and polymerization par…
Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity
2009
Heat shock protein 27 (HSP27) accumulates in stressed cells and helps them to survive adverse conditions. We have already shown that HSP27 has a function in the ubiquitination process that is modulated by its oligomerization/phosphorylation status. Here, we show that HSP27 is also involved in protein sumoylation, a ubiquitination-related process. HSP27 increases the number of cell proteins modified by small ubiquitin-like modifier (SUMO)-2/3 but this effect shows some selectivity as it neither affects all proteins nor concerns SUMO-1. Moreover, no such alteration in SUMO-2/3 conjugation is achievable by another HSP, such as HSP70. Heat shock factor 1 (HSF1), a transcription factor responsib…