Search results for "modifier"

Evaluation of Epigenetic and Radiomodifying Effects during Radiotherapy Treatments in Zebrafish

2021

Radiotherapy is still a long way from personalizing cancer treatment plans, and its effectiveness depends on the radiosensitivity of tumor cells. Indeed, therapies that are efficient and successful for some patients may be relatively ineffective for others. Based on this, radiobiological research is focusing on the ability of some reagents to make cancer cells more responsive to ionizing radiation, as well as to protect the surrounding healthy tissues from possible side effects. In this scenario, zebrafish emerged as an effective model system to test for radiation modifiers that can potentially be used for radiotherapeutic purposes in humans. The adoption of this experimental organism is fu…

New amphiphilic derivatives of poly(ethylene glycol) as surface modifiers of colloidal drug carriers

2009

Thermo-oxidative ageing of an organo-modified clay and effects on the properties of PA6 based nanocomposites

2013

a b s t r a c t In this work a careful investigation on the degradation of an organically modified montmorillonite sample (Cloisite 15A) thermal treated under different atmospheres, namely nitrogen, air and oxygen enriched atmosphere was performed. The exposure time of the thermal treatment ranged between 5 and 300 min. The chemical composition evolution as function of the thermal treatment conditions of the clay organic modifier was monitored by means of combined thermogravimetry/Fourier transform infrared spectroscopy (TGA-FTIR). Moreover, the morphological behaviour of treated Cloisite 15A sam- ples as function of the time and of the decomposition atmosphere was investigated by X-ray dif…

New amphiphilic conjugates of mono- and bis(carboxy)-PEG(2,000) polymers with lipoamino acids as surface modifiers of colloidal drug carriers

2010

Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups☆

2013

Background Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality. Objectives To assess if prolonging in utero-like oxygenation during the fetal-to-neonatal transition limits oxidative stress in the lung and brain, improving postnatal adaptation of mice pups. Material and methods Inspiratory oxygen fraction (FiO2) in pregnant mice was reduced from 21% (room air) to 14% (hypoxia) 8–12 h prior to delivery and reset to 21% 6–8 h after birth. The control group was kept at 21% during the procedure. Reduced (GSH) and oxidized (GSSG) glutathione and its precursors [γ-glut…

Novel organo-modifier for thermally-stable polymer-layered silicate nanocomposites

2015

A new novel approach for the stabilisation of polymer-clay nanocomposites has been investigated based on reacting chemically an antioxidant function, a hindered phenol moiety, with an organic modifier based on a quaternary ammonium salt. The chemically linked antioxidant-containing organic modifier (AO-OM) was then introduced into natural montmorillonite (MMt) through a cation-exchange reaction resulting in antioxidant-containing organo-modified clay (AO-OM-MMt). The new antioxidant-containing modified clay, along with other organo-modified clays having a similar organo-modifier but without the reacted antioxidant, were characterised by spectroscopic, thermogravimetric and x-ray diffraction…

Thermally-stable polymer-layered silicate nanocomposites through intercalation of novel organo-modifier

2014

Apstākļi un darbības vārdu formas T.Hārdija romānā "Kāsterbridžas mērs"

2020

Šis pētījums tika uzsākts, ņemot vērā T.Hārdija darbu popularitātes kritumu un secīgu pieaugumu pēdējās desmitgades laikā, kā arī darbības vārdu un apstākļu nozīmi daiļliteratūrā. Pētījuma mērķis bija analizēt, kā autors lieto darbības vārdu formas un apstākļus romānā Kāsterbridžas mērs, raksturojot varoņus un pildot valodas funkcijas. Tika izmantota jauktā pētījuma metode, apvienojot diskursa analīzi un kvantitatīvu pieeju stilistiskajai analīzei. Pētījuma rezultātā tika atklāts, ka ar darbības vārdu formu palīdzību autors nosaka sižeta attīstības straujumu; tie apstākļi, kas galvenokārt izmantoti ar komunikācijas darbības vārdiem, ļauj izdarīt secinājumus par romāna varoņu īpašībām; starp…

Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.

2017

Urm1 is a unique dual-function member of the ubiquitin protein family and conserved from yeast to man. It acts both as a protein modifier in ubiquitin-like urmylation and as a sulfur donor for tRNA thiolation, which in concert with the Elongator pathway forms 5-methoxy-carbonyl-methyl-2-thio (mcm5s2) modified wobble uridines (U34) in anticodons. Using Saccharomyces cerevisiae as a model to study a relationship between these two functions, we examined whether cultivation temperature and sulfur supply previously implicated in the tRNA thiolation branch of the URM1 pathway also contribute to proper urmylation. Monitoring Urm1 conjugation, we found urmylation of the peroxiredoxin Ahp1 is suppre…

Investigating the Multi-Recyclability of Recycled Plastic-Modified Asphalt Mixtures

2023

Although the benefits of asphalt recycling have been scientifically proven and several best practices are being implemented, further research is required in specific and specialized areas. One of these circumstances is the recycling of Reclaimed Asphalt Pavements (RAPs) that contain asphalt modifiers such as elastomers and/or plastomers. Following the principles of the circular economy and considering the sustainability implications of asphalt mixtures, this paper deals with the multi-recyclability of asphalt mixtures containing 50% RAP with and without a recycled plastic asphalt modifier and rejuvenating agent. The recycled plastic asphalt modifier was made of hard recycled plastics and wa…