Search results for "monitor"

A systematic review and combined analysis of therapeutic drug monitoring studies for longacting risperidone

2017

Introduction: This systematic review of therapeutic drug monitoring (TDM) identifies three long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is available on two formulations (RBP-7000 and in Situ Microparticle), but 20 TDM articles on the microsphere formulation were found. Risperidone TDM includes the serum concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, used for calculating: 1) the risperidone/9-hydroxyrisperidone (R/9-OH-R) ratio (a measure of CYP2D6; values >1 are indicative of a CYP2D6 poor metabolizer) and 2) the total risperidone concentration-to-dose (C/D) ratio (a measure of risperidone clearance with a normal value…

Quantitative relations between different concentrations of micro- and macroelements in mosses and lichens: the region of Opole (Poland) as an environ…

2010

We examined the concentration of selected metals: Al, Mn, Fe, Cu, Zn, Cd and Pb, as well as activity of 137Cs in samples of moss and lichen, collected in the area surrounding Bory Stobrawskie, a wood complex situated in southern Poland. The concentration of metals was determined by atomic absorption spectrometry. The activity of 137Cs was determined by gamma spectrometry. We used these results, as well as results published in the literature, to determine the correlation between the concentration of analytes in lichens and in mosses. The analysis of the function ln(cx,moss) = lna + bln(cx,lichen) indicated with high degree of certainty that the concentration levels of analytes accumulated in…

A comparison between calanchi landforms in central and southern Italy

2010

A chamber to test the response of radon detectors to changing environmental conditions.

2011

Radon risk assessment is carried out with accurate measurements with active or passive instrumentation. All radon detectors must be calibrated and tested using a radon chamber containing a known concentration of radon produced by specific sources of 226Ra. Some of the chambers can also be used to test the response of detectors as a function of environmental conditions. In this case, it can be inferred a calibration curve with respect to changing of the parameter considered. For this aim, a new chamber radon was designed and realized to perform both calibration of instruments and to study the detector response in a large range of variation of the environmental parameters (pressure, 700 - 110…

LIFE AForClimate: approcci predittivi per una selvicoltura del faggio in sintonia con il clima

2019

Numerosi studi hanno dimostrato che l’incremento delle temperature medie stagionali e le variazioni nel regime stagionale delle precipitazioni influenzano direttamente la variabilità di crescita dei popolamenti forestali. Conoscere la risposta delle foreste alla variabilità del clima è propedeutica a calibrare gli interventi selvicolturali per garantire minore stress alle piante e una migliore efficienza ecosistemica. Il progetto LIFE AForClimate (LIFE15 CCA/IT/000089 - Adaption of FORest management to CLIMATE variability: an ecological approach) mira a fornire soluzioni concrete per realizzare una gestione forestale efficace nell’adattamento ai cambiamenti climatici e definire un metodo pe…

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers

2011

Abstract Purpose: To facilitate development of innovative immunotherapy approaches, especially for treatment concepts exploiting the potential benefits of personalized therapy, there is a need to develop and validate tools to identify patients who can benefit from immunotherapy. Despite substantial effort, we do not yet know which parameters of antitumor immunity to measure and which assays are optimal for those measurements. Experimental Design: The iSBTc-SITC (International Society for Biological Therapy of Cancer-Society for Immunotherapy of Cancer), FDA (Food and Drug Administration), and NCI (National Cancer Institute) partnered to address these issues for immunotherapy of cancer. Here…

Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules?

2002

alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., the group II CD1 antigens, which are split into CD1D1 and CD1d2. Several T cell subsets have been shown to interact with murine CD1 antigens, including NK cells or "natural T cells" with the invariant V alpha 14 J alpha 281 TCR chain. Even if TAP defects may prevent classical endogenous antigen presentation in tumor cell lines, antigen presentation via CD1 is still functional. …

Improved inter-observer agreement of an expert review panel in an oncology treatment trial--Insights from a structured interventional process.

2015

Abstract Purpose Oncologic imaging is a key for successful cancer treatment. While the quality assurance (QA) of image acquisition protocols has already been focussed, QA of reading and reporting offers still room for improvement. The latter was addressed in the context of a prospective multicentre trial on fluoro-deoxyglucose (FDG)–positron-emission tomography (PET)/CT-based chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC). Material and methods An expert panel was prospectively installed performing blinded reviews of mediastinal NSCLC involvement in FDG–PET/CT. Due to a high initial reporting inter-observer disagreement, the independent data monitoring committee (I…

Relationship between recruitment and mother plant vitality in the alien species Acacia cyclops A. Cunn. ex G. Don

2014

Acacia cyclops is a widespread invader in Mediterranean-climate regions. However, although its naturalization in the Mediterranean Basin dates back only a few years ago, and the invasion process has not been studied hitherto. We investigated seedlings recruitment strategy adopted by A. cyclops in a small island (Lampedusa, Italy) where its natural regeneration was strictly confined under mother plants canopy. Healthy plants (DCP), plants at incipient senescence (SCP) and dead plants (DP) were distinguished according to vitality and canopy status. Living plants were also characterized in relation to leaf C and N isotope composition. Regeneration pattern (seedlings and saplings abundance) was…

Leaf reflectance variation along a vertical crown gradient of two deciduous tree species in a Belgian industrial habitat

2015

Abstract: The reflectometry of leaf asymmetry is a novel approach in the bio-monitoring of tree health in urban or industrial habitats. Leaf asymmetry responds to the degree of environmental pollution and reflects structural changes in a leaf due to environmental pollution. This paper describes the boundary conditions to scale up from leaf to canopy level reflectance, by describing the variability of adaxial and abaxial leaf reflectance, hence leaf asymmetry, along the crown height gradients of two tree species. Our findings open a research pathway towards bio-monitoring based on the airborne remote sensing of tree canopies and their leaf asymmetric properties. (C) 2015 Elsevier Ltd. All ri…