Search results for "movement"
showing 10 items of 2021 documents
Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells
2021
Triple-negative breast cancer (TNBC) is a highly aggressive disease with invasive and metastasizing properties associated with a poor prognosis. The STAT3 signaling pathway has shown a pivotal role in cancer cell migration, invasion, metastasis and drug resistance of TNBC cells. IL-6 is a main upstream activator of the JAK2/STAT3 pathway. In the present study we examined the impact of the NO-donor glyceryl trinitrate (GTN) on the activation of the JAK2/STAT3 signaling pathway and subsequent migration, invasion and metastasis ability of TNBC cells through in vitro and in vivo experiments. We used a subtoxic dose of carboplatin and/or recombinant IL-6 to activate the JAK2/STAT3 signaling path…
PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.
2015
Abstract Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung squamous cell carcinomas (LSCC). Tumor-specific PARD3 alterations were found in 8% of LSCCs examined, placing PARD3 among the most common tumor suppressor genes in this malignancy. Most PAR3-mutant proteins exhibited a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions, bind atypical protein kinase C, activate RAC1, and activate STAT3 at cell confluence. Thus, PARD3 alterations prevented the formation of c…
Inter-individual variability in aroma release during sweet mint consumption
2011
Inter-individual variations of in vivo aroma release kinetics have been observed widely in the literature. However, the corresponding causes are yet to be clearly identified. For this purpose, 68 subjects in whom salivary flow rates (at rest and Parafilm™-stimulated) had been determined were recruited for the study. The release of menthone was measured using atmospheric pressure ionisation–mass spectrometry during the consumption of a sweet mint tablet. The subjects complied with an imposed protocol of oral movements. Inter-individual variability was investigated through a qualitative analysis of the oral movements inducing menthone release, and through quantitative analysis. Swallowing eve…
Institutionalization and Depoliticization of the Right to the City: Changing Scenarios for Radical Social Movements
2016
The right to the city, a concept previously associated with radical social movements, has been accepted by several governments and has inspired new public policies. However, some authors see this process of institutionalization as involving a loss of a significant part of the radical origins of the concept. This article approaches this process and the new opportunities and limitations it may entail for social movement organizations with a more radical perspective on the right to the city. We explore the paradigmatic case of Brazil and the action of a particular organization, the Movimento dos Sem Teto da Bahia (MSTB, or Homeless Movement of Bahia) in the city of Salvador. We draw on the dis…
Rethinking Samir Amin’s legacy and the case for a political organization of the global justice movement
2019
Juego argues that the new Internationale’s “primary organizational function should be the global coordination of actions of progressive grassroots movements from country to country.” He calls for a ‘learning organization,’ where the new Internationale supports “a continuous dialogue between bottom-up and top-down approaches to decision-making.” He sees it as “[a]kin to a global coordinating council” meaning that it works to integrate and synthesize the “varying initiatives, campaigns, and mass actions at all geographical levels of membership” while remaining mindful of the “dialectics between reform and revolution.” The new Internationale must, moreover, be “grounded on a pragmatic understa…
Perceptions of leadership behavior and the relationship to athletes among Scandinavian coaches
2014
Published version of an article in the journal: Scandinavian Sport Studies Forum. Also available from the publisher at: http://sportstudies.org/2014/11/25/perceptions-of-leadership-behavior-and-the-relationship-to-athletes-among-scandinavian-coaches/ -Open Access The purpose of this study was to investigate the relationship between the perceptions of leadership behavior and coach–athlete relationship in Scandinavian coaches. A secondary purpose was to investigate if differences in national sport education, level of coaching and coaching experiences in individual or team sport have an influence on leadership behavior and coach–athlete relationships. One hundred and forty nine coaches at inte…
Experimental and Modeling Analyses of Human Motion Across the Static Magnetic Field of an MRI Scanner
2021
It is established that human movements in the vicinity of a permanent static magnetic field, such as those in magnetic resonance imaging (MRI) scanners induce electric fields in the human body; this raises potential severe risks of health to radiographers and cleaners exposed routinely to these fields in MRI rooms. The relevant directives and parameters, however, are based on theoretical models, and accurate studies on the simulation of the effects based on human movement data obtained in real conditions are still lacking. Two radiographers and one cleaner, familiar with MRI room activities and these directives, were gait analyzed during the execution of routine job motor tasks at different…
A real-time webcam based Eye Ball Tracking System using MATLAB
2015
Eye Ball Tracking System is a device which is intended to assist patients that cannot perform any voluntary tasks related to daily life. Patients who only can control their eyes can still communicate with the real-world using the assistive devices like one proposed in this paper. This device provides a human computer interface in order to take decisions based on their eye movement. A real time data stream is captured via webcam that transfers data serially to MATLAB. Then a sequential image processing scheme segments the iris of the eye and calculates the centroid, thereby generating control signal with the help of a reference axis. The control signals are then used to manipulate the positi…
MOTOR COORDINATION DIFFICULTIES IN CHILDREN WITH LEARNING DISABILITIES
2016
Nowadays increasing the number of children with learning disabilities in comprehensive schools of Latvia, so it is necessary preventive measures during schooltime. One of the support measures are short movement activity in academic lessons. The aim of article is theoretical analyze the correlations between motor coordination difficulties and the child's academic achievement and find out primary school teachers' views on possible support for children with learning disabilities. Main findings – development of motor coordination in children of primary schools is effective when using short movement breaks in classroom. Research methods: analysis of scientific and methodological literature, a su…
L’écriture et le graphisme à l’ère de la linguistique psychologique
2016
This study deals with the conception of “writing” within the German humanities during the « psychological turn » of the last half of the XIXth - the beginning of the XXth centuries. The focal point is “graphism” and “writing” understood as “expressive movements” (Ausdrucksbewegungen), this notion being bound to the concept of “verbal gesture” within the trend of “psychological linguistics” (1850-1930). Inspired initially by the morphological and physiognomonic tradition (J. Lavater, J. W. Goethe, J. Engel, C. Carus, Th. Piderit), this conception considers language as a particular kind of “expressive movements”. This vision comes back to the German psychology of consciousness elaborated by J…