Search results for "movement"
showing 10 items of 2021 documents
Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1.
2006
When lactate accumulation in a tumor microenvironment reaches an average concentration of 10-20 mM, it tends to reflect a high degree of malignancy. However, the hypothesis that tumor-derived lactate has a number of partially adverse biological effects on malignant and tumor-associated host cells requires further evidence. The present study attempted to evaluate the impact of lactate on the process of angiogenesis, in particular on the formation of tubular structures. The endothelial cell (EC) network in desmoplastic breast tumors is primarily located in areas of reactive fibroblastic stroma. We employed a fibroblast-endothelial cell co-culture model as in vitro angiogenesis system normally…
E-selectin modulates the malignant properties of T84 colon carcinoma cells.
2002
The extravasation of metastatic cells is regulated by molecular events involving the initial adhesion of tumor cells to the endothelium and subsequently the migration of cells in the host connective tissue. E-selectin on endothelial cells and sialyl Lewis X carbohydrate component on tumor cells are mainly involved in the adhesion of colon carcinoma cells to the endothelium of target organ. Interaction of T84 colon cancer cells to purified E-selectin in vitro caused an increase in the tyrosine phosphorylation of a number of proteins as well as the modulation of cellular properties correlated to the metastatic phenotype. Specifically, E-selectin-stimulated actin reorganization, increased coll…
Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.
2012
Abstract The lymphatic vasculature preserves tissue fluid balance by absorbing fluid and macromolecules and transporting them to the blood vessels for circulation. The stepwise process leading to the formation of the mammalian lymphatic vasculature starts by the expression of the gene Prox1 in a subpopulation of blood endothelial cells (BECs) on the cardinal vein (CV) at approximately E9.5. These Prox1-expressing lymphatic endothelial cells (LECs) will exit the CV to form lymph sacs, primitive structures from which the entire lymphatic network is derived. Until now, no conclusive information was available regarding the cellular processes by which these LEC progenitors exit the CV without co…
An ecological dynamics framework for the acquisition of perceptual-motor skills in climbing
2016
Uncertainty in extreme sports performance environments, like rock and ice climbing, provides considerable psycho-emotional and physiological demands which challenge the acquisition of perceptual-motor skills. An ecological dynamics theoretical framework adopts concepts and tools of nonlinear dynamics and ecological psychology to investigate and model the relationships that emerge in extreme sports between athletes and their performance environments. In this relation, the interactions of athletes with key objects, surfaces, events and significant others during a sport like climbing emerge from interdependent personal, task and environmental constraints on performance. Performance behaviours …
Head and Body Coordination during Locomotion and Complex Movements
1994
Publisher Summary This chapter discusses theory in which it is argued that during complex movements, the head is stabilized intermittently under the control of gaze, and that this stabilization allows the head to serve as an inertial guidance platform for the control of multilimb movement. The otolithic organs, sacculus and utriculus, are inertial detectors of linear acceleration of the head in the plane of their macula. It is well established that in normal gravity conditions, although the perceived gravitational vertical deviates from the objective vertical by a few degrees, gravitational reference is used not only for posture but also for perceptual tasks that involve orientation in spac…
Assessment of data and parameter uncertainties in integrated water-quality model
2011
In integrated urban drainage water quality models, due to the fact that integrated approaches are basically a cascade of sub-models (simulating sewer system, wastewater treatment plant and receiving water body), uncertainty produced in one sub-model propagates to the following ones depending on the model structure, the estimation of parameters and the availability and uncertainty of measurements in the different parts of the system. Uncertainty basically propagates throughout a chain of models in which simulation output from upstream models is transferred to the downstream ones as input. The overall uncertainty can differ from the simple sum of uncertainties generated in each sub-model, dep…
Optimization model predictions for postural coordination modes
2003
International audience; This paper examines the ability of the dynamic optimization model to predict changes between in-phase and anti-phase postural modes of coordination and to evaluate influence of two particular environmental and intentional constraints on postural strategy. The task studied was based on an experimental paradigm that consisted in tracking a target motion with the head. An original optimal procedure was developed for cyclic problems to calculate hip and ankle angular trajectories during postural sway with a minimum torque change criterion. Optimization results give a good description of the sudden bifurcation phase between in-phase and anti-phase postural coordination mo…
Pattern recognition in cyclic and discrete skills performance from inertial measurement units
2014
The aim of this study is to compare and validate an Inertial Measurement Unit (IMU) relative to an optic system, and to propose methods for pattern recognition to capture behavioural dynamics during sport performance. IMU validation was conducted by comparing the motions of the two arms of a compass, which was equipped with IMUs and reflective landmarks detected by a multi-camera system. Spearman’s rank correlation tests showed good correlations between the IMU and multi-camera system, especially when the angles were normalized. Bland-Altman plot, root mean square and the normalized pairwise variability index showed low differences between the two systems, confirming the good accuracy level…
Hill's Equation in the Arm Push of Shot Put
2016
Aims: The purpose of this paper was to continue the previous study of arm rotation movement where A.V. Hill’s force-velocity relationship was transformed into a constant maximum power model consisting of three different components of power. Methodology: In the present study a new model of Hill’s equation was applied for accelerated motions. This theoretically derived model of further development of Hill’s force-velocity relationship was tested by fitting it into two arm push measurements of shot put experiments. The results of the further development of Hill’s equation for accelerated motions were compared with the mechanics of the constant power model of the previous study. Results: The an…
The role of plant species on runoff and soil erosion in a Mediterranean shrubland.
2021
Shrubland is a Mediterranean biome characterized by densely growing evergreen shrubs adapted to fire events. To date, scientific research has focused on the impact of vegetation on soil erosion mainly through the control that plant biomass or plant cover exerts on sediment delivery and runoff discharge, being the individual plant species influence on hydrological and erosional processes not achieved in detail. The objective of this research is to determine: i) runoff and soil losses in a shrubland-covered rangeland at Sierra de Enguera, Spain; and ii) how four plant species affect soil and water losses. We measured soil cover, soil properties, runoff discharge and sediment yield under natur…