Search results for "mta"

A systematic review and meta-analysis on the effectiveness of xenograft to prevent periodontal defects after mandibular third molar extraction.

2021

Background To evaluate the use of guided bone regeneration with xenograft to prevent periodontal defect in the distal aspect of the second molar after the surgical removal of the mandibular third molar. Material and Methods Three electronic databases (Pubmed, Cochrane Library and Scopus) were searched in April 2020. Randomized clinical trials in non-smokers and healthy patients, with at least six months follow-up, comparing periodontal probing depth, clinical attachment level, alveolar bone level and adverse events were selected by two independent investigators. The risk of bias assessment of the selected studies was evaluated by means of the Cochrane Collaboration’s Tool. Finally, a meta-a…

The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

2022

Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was synthesized as cis-restricted-combretastatin-A-4-analogue and then chemically modified to have improved solubility and a wider therapeutic index as compared to vinca alkaloids and taxanes. On these bases, a new class of tricyclic compounds, containing the [1,2]oxazole ring and an isoindole moiety, has been synthetized, among which SIX2G emerged as improved MTA. Several findings highlighted the ability of some chemotherapeutics to induce immunogenic cell death (ICD), which is defined by the cell surface translocation of Calreticulin (CAL…

The "Historia de la doncella Teodor" in Burgos’ Printing Press: Regarding a New Edition from Juan de Junta’s Workshop, c. 1535-1540

2020

En este trabajo se da noticia y se lleva a cabo el estudio tipobibliográfico de una edición sine notis de la Historia de la doncella Teodor. El análisis permite identificar la impresión en Burgos en el taller de Juan de Junta, c. 1535-1540. El rasgo material que singulariza este impreso es que la última hoja del primer cuaderno ha sido remedada por una copia manuscrita que no solo reproduce la tipografía original, sino también, a plumilla, las estampas. El estudio textual e iconográfico nos permitirá identificar la fuente del folio contrahecho.

Production of high value added nutraceuticals in a multi-trophic aquaculture system within a closed circuit marine hatchery (NUTRAQUA)

2022

Mazā ērgļa Aquila pomarina C.L. Brehm taksonomija, izplatība, skaits un ekoloģija Latvijā

1999

Advisor: Vīksne, Jānis

Latvijas Vēstures Institūta Žurnāls. 2016, Nr. 2 (99)

2016

Valsts kultūrkapitāla fonds

CISPLATIN (C) AND ALIMTA (A) WITH PANITUMUMAB FOR ADVANCED NON-SQUAMOUS NON-SMALL CELL LUNG CANCER (NS-NSCLC): A PHASE I-DOSE FINDING STUDY.

2012

Background The treatment of NSCLC is rapidly changing since new drugs are becoming available. Recently, CA has become a standard for the first line treatment of NS-NSCLC. Previous clinical studies have shown that anti-EGFR MoAb may be added to chemotherapy, but the identification of a molecular signature can predict their activity and better define their true role. Aims In absence of data about the MTD of Panitumumab (a MoAb targeting the EGFR, potentially active in NS-NSCLC) when associated to chemotherapy, we decided to assess the optimal dose of panitumumab in combination with CA. Moreover, in view of a future phase II study, all pts will be studied for the following molecular characteri…

CORRELATION BETWEEN THE CHEMICAL-PHYSICAL PROPERTIES OF CNT AND MACROSCOPIC PROPERTIES OF RELATED NANOCOMPOSITES: A STATISTICAL APPROACH

2014

In the frame of this work, two different samples of CNTs, namely CNT 1 and CNT 2, were synthesized [1] with different degree of purity and aspect ratio and used as fillers either without any treatment or after a plasma-oxidation, to prepare polycarbonate (PC)-based nanocomposites by melt mixing. The influence of plasma treatment, filler content and type of CNTs on the mechanical, dynamic-mechanical, and electrical properties of the materials was assessed by a two level full factorial design. The morphological analysis carried out by SEM and TEM evidenced the formation of a nanohybrid structure when oxidized CNTs were used as filler. Generally speaking, CNT 2 showed the best dispersion and t…

Camtasia Studio, creació d’animacions multimèdia educatives

2009

Camtasia Studio es un programa diseñado para la grabación en pantalla de ordenador y su posterior edición. De esta manera se pueden crear animaciones multimedia con capacidades interactivas de manera sencilla en comparación con los tradicionales editores de vídeo y/o animación. En este artículo se estudian la estructura de este programa y las posibilidades de su aplicación al entorno educativo.

Comparative cytotoxicity evaluation of eight root canal sealers

2017

Background The aim of the present study is to evaluate and compare the cytotoxic effects of eight root canal sealers (BioRoot RCS, TotalFill BC Sealer, MTA Fillapex, Sealapex, AH Plus, EasySeal, Pulp Canal Sealer, N2) on immortalized human gingival fibroblasts over a period of 24, 48 and 72 hours. Material and Methods Immortalized human gingival fibroblast-1 HGF-1 (ATCC CRL-2014) were incubated. Root canal sealers were then placed into sterile, cylindrical Teflon moulds. The extraction was made eluting the sealers in cell culture medium. Cells (1 × 104) were seeded in each well of a 96-well plate and incubated for 24 h at 37°C. Cultures were then exposed to 100 μL of the extracts medium. Th…