Search results for "multiple"
showing 10 items of 2678 documents
Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination.
2010
Abstract Apoptosis of oligodendrocytes (ODCs), the myelin-producing glial cells in the CNS, plays a central role in demyelinating diseases such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. To investigate the mechanism behind ODC apoptosis in EAE, we made use of conditional knockout mice lacking the adaptor protein FADD specifically in ODCs (FADDODC-KO). FADD mediates apoptosis by coupling death receptors with downstream caspase activation. In line with this, ODCs from FADDODC-KO mice were completely resistant to death receptor-induced apoptosis in vitro. In the EAE model, FADDODC-KO mice followed an ameliorated clinical di…
Persistent inflammation alters the function of the endogenous brain stem cell compartment
2008
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation…
Microcirculatory dysfunction in sepsis: a pathogenetic basis for therapy?
2000
Sepsis is a frequent complication of multiple organ dysfunction syndrome and remains a major problem of intensive care medicine. It is also a common factor in the final cause of death in hospital populations. Clinical observations, assisted by invasive monitoring techniques as well as pathological-anatomical studies, clearly indicate that microcirculatory dysfunction lies at the centre of sepsis pathogenesis. Numerous animal models, from rodents to primates, many of which employ bacteria or their toxins, especially endotoxins, have helped to shed light on the pathomechanisms leading to this dysregulation in the peripheral circulation. Among these are activation of humoral and cellular infla…
Evaluation of the Economic and Environmental Performance of Low-Temperature Heat to Power Conversion using a Reverse Electrodialysis – Multi-Effect D…
2019
In the examined heat engine, reverse electrodialysis (RED) is used to generate electricity from the salinity difference between two artificial solutions. The salinity gradient is restored through a multi-effect distillation system (MED) powered by low-temperature waste heat at 100 °C. The current work presents the first comprehensive economic and environmental analysis of this advanced concept, when varying the number of MED effects, the system sizing, the salt of the solutions, and other key parameters. The levelized cost of electricity (LCOE) has been calculated, showing that competitive solutions can be reached only when the system is at least medium to large scale. The lowest LCOE, at a…
Comparison of different sets of array configurations for multichannel 2D ERT acquisition
2017
Abstract Traditional electrode arrays such Wenner-Schlumberger or dipole-dipole are still widely used thanks to their well-known properties but the array configurations are generally not optimized for multi-channel resistivity measures. Synthetic datasets relating to four different arrays, dipole-dipole (DD), pole-dipole (PD), Wenner-Schlumberger (WS) and a modified version of multiple gradient (MG), have been made for a systematic comparison between 2D resistivity models and their inverted images. Different sets of array configurations generated from simple combinations of geometric parameters (potential dipole lengths and dipole separation factors) were tested with synthetic and field dat…
CHP (combined heat and power) retrofit for a large MED-TVC (multiple effect distillation along with thermal vapour compression) desalination plant: H…
2016
Abstract Integrated power plants in “dual purpose” configuration may represent a viable option for energy cost abatement of desalted water produced by MED-TVC (Multiple Effect Distillation along with Thermal Vapour Compression). In this paper an existing large MED-TVC plant with a 36,000 m 3 /day capacity is studied: a plant retrofit is designed, based on a steam power plant with condensation and steam extraction used to drive the steam ejector. As the plant operates in CHP (Combined Heat and Power) mode, the possibility to assess the integrated “CHP + MED-TVC” as high efficiency cogeneration according to Directive 2004/8/EC is discussed. Based on a model developed in Engineering Equation S…
ELECTRE TRI-based approach to the failure modes classification on the basis of risk parameters: An alternative to the risk priority number
2017
Proposing an ELECTRE TRI-based approach for the failure modes classification into predefined and ordered risk classes.Direct identification of failure modes on which performing the corrective actions with priority.Easy definition of risk classes on the basis of DMs expertise and perception of the industrial context considered.Application to dairy manufacturing processes. Failure Mode and Effects Analysis (FMEA) is an engineering technique aimed at the detection of potential failures, their causes and consequences on the system/process under investigation. When used for the failure modes prioritization, FMEA is also referred to as Failure Mode, Effects and Criticality Analysis (FMECA). In tr…
A novel frequency reuse scheme for coordinated multi-point transmission
2010
La transmisión multipunto coordinada (CoMP) se considera en 3GPP LTE-Advanced como una técnica clave para mejorar el rendimiento en el borde de la célula. Con el fin de apoyar la asignación conjunta de asignación de recursos entre células coordinadas en sistemas CoMP, es necesario diseñar esquemas eficientes de reutilización de frecuencias. Sin embargo, la mayoría de los esquemas de reutilización de frecuencias existentes no son adecuados para transmisión CoMP debido a que no consideran el escenario de transmisión conjunta multicelular en su regla de reutilización de frecuencias. Para resolver este problema, en este trabajo se propone un esquema de reutilización de frecuencias que divide el…
PCM Thermal Energy Storage in Buildings: Experimental Study and Applications
2015
Abstract The study aims at analyzing the performance of Phase Change Materials (PCMs) in residential housing for different climates. This paper presents the results of an experiment performed in the Concordia University Solar Simulator and Environmental Chamber research facility (SSEC, Montreal, Canada). PCM boards were embedded on the back wall of a test hut placedin the climatic chamber. Several experiments were performed to explore the potential for verification of the proposed analysis and to produce enough data to perform model calibrations. Results show a strong increase in the apparent thermal inertia of the room allowing for a reduction in daily temperature fluctuations in the test …
Performance analysis of Alamouti coded OFDM systems over wideband MIMO car-to-car channels correlated in time and space
2014
In this paper, the performance of Alamouti coded orthogonal frequency division multiplexing (OFDM) systems over car-to-car (C2C) fading channels correlated in time and space is analyzed. Taking different geometrical scattering models into account, a generalized expression of the time-variant transfer function (TVTF) is derived for wideband multiple-input multiple-output (MIMO) C2C channels. We present a generalized expression for the bit error probability (BEP), which will be used to describe the performance of Alamouti coded OFDM systems over different types of C2C channel models, such as the rectangle model, the tunnel model, the street model, and the curve model. The effect of the maximu…