Search results for "multiscale model"
showing 3 items of 23 documents
Effect of the Time Dependent Loading of Type IV Cylinders using a Multiscale Model
2019
International audience; The current requirements for composite cylinders are still based on an arbitrary approach derived from the behaviour of metal structures, that the designed burst pressure should be at least 2.5 times the maximum in-service pressure [1]. This could lead to an over-designed composite cylinder for which the weight saving would be less than optimum. Moreover, predicting the lifetime of composite cylinders is a challenging task due to their anisotropic characteristics. A federal research institute in Germany (BAM) has proposed a minimum load-cycle requirement that mitigates this issue by using a Monte-Carlo analysis of the burst test results [2-3]. To enrich this study, m…
Analyse multiéchelle d'un composite textile = Multiscale analysis of a textile composite
2009
National audience; On propose dans cette étude de comprendre le comportement mécanique d'un composite textile. Pour ce faire, l'étude se scinde en deux parties distinctes. Dans cet article, nous présentons la modélisation multiéchelle qui fait suite à une étude expérimentale. Son objectif est double : comprendre la nature du comportement macroscopique observé et expliquer l'origine des endommagements susceptibles d'apparaître. L'étude expérimentale du matériau fait l'objet d'un premier article.
Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice
2020
Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies. In turn, these experiments and studies can be used to validate or improve the models. This iterative loop of dry and wet lab work is successful when biomedica…