Search results for "multivariate"
showing 10 items of 1520 documents
Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women
2014
AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus (HCV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-G1, 46% F3-F4, and previous PEG-α/RBV failure (7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HCV-RNA-positive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virolo…
Predicting gully occurrence at watershed scale: Comparing topographic indices and multivariate statistical models
2020
In this study, the ability of five topographic indices to predict the gully trajectories observed in two adjacent watersheds located in Sicily (Italy) was evaluated. Two of these indices, named MSPI and MTWI, as far as we know, have never been employed to this aim. They were obtained by multiplying the stream power index (SPI) and the topographic wetness index (TWI), respectively, by the convergence index (CI). The predictive ability of the topographic indices was measured by using both cut-off independent (AUC: area under the receiver operating characteristic curve) and dependent statistics (Cohen's kappa index κ, sensitivity, specificity). These statistics were calculated also for 100 MAR…
Psychosocial and environmental correlates of active commuting for university students.
2009
Abstract Objective To examine psychosocial and environmental correlates of active commuting to university (ACU) and explore its association with overall physical activity among college students. Methods The sample included 518 students (mean 22.4 years; 59.7% female) from two universities in Valencia, Spain. Weekly estimations of energy expenditure from ACU and total physical activity were obtained. Socio-economic status, self-efficacy, barriers to active transport, access to car and motorbike, access to public transport, walking and cycling facilities and distance to university were assessed. Data were collected April and May of 2009, using a self-administered survey. A structural equation…
A multivariate insight into ionic liquids toxicities
2014
A multivariate insight into Ionic Liquids' (ILs) toxicity, a broad term highly dependent on the biological systems adopted as “sensors”, addressed four main groups of toxicities: aquatic toxicity, toxicity towards fungi and bacteria, cytotoxicity towards IPC-81 rat cell lines and acetylcholinesterase enzyme inhibition. This approach, summarizing toxicity information available from a huge amount of scattered literature data, allowed derivation of aquatic toxicity scores for 104 ILs and bacteria and fungi toxicity scores for 87 ILs as well as identification of a correlation between aquatic ecotoxicity and the response of IPC-81 rat cell lines. Further evidence on the effects of cation structu…
Mapping of penetrometer resistance in relation to tractor traffic using multivariate geostatistics
2007
Abstract The traffic of agricultural machines can cause soil compaction and high variability of soil structure, both along normal lines and along those parallel to the field plane. The aim of this work was to investigate the potential of an electronic penetrometer, a GPS, a GIS and geostatistical techniques for mapping soil compaction. In July 2003 soil cone penetrometer resistance was measured using a semi-automatic electronic penetrometer in a sandy-silt soil (Vertic Xerochrept) of inland Sicily where a three-year rotation wheat ( Triticum durum Desf.)–wheat–tomato ( Solanum lycopersicum L.) was practiced. The measurements were carried out along three parallel 3-m long transects, from the…
French firms’ strategies for protecting their intellectual property
2012
In attempting to protect their innovations, firms can choose from a range of mechanisms, which may be either non-statutory (trade secrets, design complexity, and lead-time advantage over competitors) or statutory (patent, design registration, trademark, copyright). Yet, little is known about how firms do actually make their choices from among these different appropriability mechanisms. The aim of this paper is to determine how French firms’ use of intellectual property protection mechanisms relates to the type of innovation, the characteristics of the market sector in which they operate, the firms’ characteristics, and their human resources strategies. Our empirical model draws on four Fren…
Effect of two antihypertensive combinations on metabolic control in type-2 diabetic hypertensive patients with albuminuria: a randomised, double-blin…
2001
The objective of this study was to compare, at equal blood pressure (BP) reduction, the effect of two different combinations on metabolic control and albuminuria in type 2 diabetic hypertensive patients with albuminuria. This was a prospective, randomised, double-blind, parallel, controlled trial carried out in 11 Spanish hospitals. A total of 103 type 2 diabetic patients with stable albuminuria and BP not controlled on monotherapy were randomised of which 93 finished the study. After a 4-week single-blind placebo period, patients were randomised to verapamil SR/trandolapril 180/2 mg (VT) or to enalapril/hydroclorothiazide 20/12.5 mg (EH). Treatment duration was 6 months. The main outcome m…
Expanded criteria for liver transplantation in patients with cirrhosis and hepatocellular carcinoma
2008
Orthotopic liver transplantation (OLT) selection for patients with hepatocellular carcinoma (HCC) is a matter of debate. The Milan criteria (MC) have been largely adopted by the international community. The main aim of this study was to evaluate the survival rates and recurrence probabilities of a new proposal for criteria (up to 3 tumors, each no larger than 5 cm, and a cumulative tumor burden </= 10 cm). Patients with cirrhosis and HCC included on the waiting list (WL) from 1991 to 2006 were retrospectively analyzed. Outcomes in patients who had tumors within and beyond the MC were compared. The survival analysis was done (1) with the intention-to-treat principle and (2) among transplante…
Multivariate optimization of the hollow fibre liquid phase microextraction of muscimol in human urine samples.
2016
Abstract A liquid phase microextraction based on hollow fibre followed by liquid chromatographic determination was developed for the extraction and quantitation of the hallucinogenic muscimol from urine samples. Method applicability on polar hallucinogens was also tested on two alkaloids, a psychedelic hallucinogen, tryptamine and a polar amino acid, tryptophan which exists in its charged state in the entire pH range. A multivariate design of experiments was used in which a half fractional factorial approach was applied to screen six factors (donor phase pH, acceptor phase HCl concentration, carrier composition, stirring rate, extraction time and salt content) for their extent of vitality i…
Incidencia de factores personales y contextuales sobre el uso de los recursos tecnológicos por el alumnado en América Latina
2021
El uso de las tecnologías de la información y de la comunicación (TIC) por parte de alumnado refleja si el proceso de integración es apropiado. No obstante, la tipología de uso de las TIC en el alumnado no se ha establecido de forma empírica en función de su uso en casa y el centro educativo. Así, el propósito del artículo es determinar la estructura del uso de las TIC por parte del alumnado, junto con la influencia de factores personales y contextuales. Se ha empleado un diseño correlacional, siendo la muestra el alumnado de sexto curso de América Latina que ha respondido al cuestionario sobre uso de las TIC en el Tercer Estudio Regional Comparativo y Explicativo (TERCE). El análisis de da…