Search results for "multivariate"

Combining Pharmacokinetics and Vibrational Spectroscopy: MCR-ALS Hard-and-Soft Modelling of Drug Uptake In Vitro Using Tailored Kinetic Constraints

2022

Raman microspectroscopy is a label-free technique which is very suited for the investigation of pharmacokinetics of cellular uptake, mechanisms of interaction, and efficacies of drugs in vitro. However, the complexity of the spectra makes the identification of spectral patterns associated with the drug and subsequent cellular responses difficult. Indeed, multivariate methods that relate spectral features to the inoculation time do not normally take into account the kinetics involved, and important theoretical information which could assist in the elucidation of the relevant spectral signatures is excluded. Here, we propose the integration of kinetic equations in the modelling of drug uptake…

Multivariate nonparametric tests in a randomized complete block design

2003

AbstractIn this paper multivariate extensions of the Friedman and Page tests for the comparison of several treatments are introduced. Related unadjusted and adjusted treatment effect estimates for the multivariate response variable are also found and their properties discussed. The test statistics and estimates are analogous to the traditional univariate methods. In test constructions, the univariate ranks are replaced by multivariate spatial ranks (J. Nonparam. Statist. 5 (1995) 201). Asymptotic theory is developed to provide approximations for the limiting distributions of the test statistics and estimates. Limiting efficiencies of the tests and treatment effect estimates are found in the…

Penalized inference in multivariate ordered logistic models: theory and applications

2011

Assessment of susceptibility to earth-flow landslide using logistic regression and multivariate adaptive regression splines: A case of the Belice Riv…

2015

Abstract In this paper, terrain susceptibility to earth-flow occurrence was evaluated by using geographic information systems (GIS) and two statistical methods: Logistic regression (LR) and multivariate adaptive regression splines (MARS). LR has been already demonstrated to provide reliable predictions of earth-flow occurrence, whereas MARS, as far as we know, has never been used to generate earth-flow susceptibility models. The experiment was carried out in a basin of western Sicily (Italy), which extends for 51 km 2 and is severely affected by earth-flows. In total, we mapped 1376 earth-flows, covering an area of 4.59 km 2 . To explore the effect of pre-failure topography on earth-flow sp…

Multivariate karyomorphometric analysis and taxonomic implications in Allium sect. Cupanioscordum (Amaryllidaceae)

2015

Significant karyological variation occurs amongst different taxa/populations in the A. cupani group. The ancestral diploid chromosome complement is 2n = 16 (x = 8), but populations of A. cupani s.l. also exhibit dysploidy (2n = 14), polyploidy (2n = 4x = 32, 2n = 4x = 30). These different chromosome assets are associated to specific diagnostic morphological characters and well-defined eco-geographical patterns, which cluster different taxa and populations in 5 series (Brullo&al. 1995, 2008). In order to test the impact of inter-and intra-specific variation in chromosome structure on the systematic treatment of the A. cupani group and its contribution to allow comparing and understanding aff…

Phytoplankton dynamics in two reservoirs with different trophic state (Lake Rosamarina and Lake Arancio, Sicily, Italy)

1998

Two man-made Sicilian lakes of differing trophic status were sampled weekly for a year, in order to compare their phytoplankton dynamics and to identify their driving factors. The water bodies store comparable volumes but the eutrophic Lake Arancio may be considered to be a shallow lake whereas the mesotrophic Lake Rosamarina is deep. The dynamics of their principal physical, chemical and biological features were analysed using, among others, Canonical Community Ordination. The results obtained suggest that increased nutrient availability causes an increase of phytoplankton biomass but no community change nor any alteration to the typical assemblages supported. The major influence in the mo…

Multivariate analyses for the study of behavior: an integrated approach

2008

Simple quantitative evaluations of isolate behavioral elements (i.e. frequencies, durations, per cent distributions) are not representative of the whole behavioral structure [1]. As suggested in a landmark paper from Spruijt and Gispen [2], it is only through the evaluation of the inter-relations among behavioral elements that it is possible to explore behavior from very different points of view, greatly beyond what the human eye can intuitively interpret. In the present paper a brief outline of different multivariate techniques for behavioral analyses will be presented in the attempt to underline the feasibility of their integration.

Identidad deportiva en adolescentes españoles: propiedades psicométricas de la versión en español de la escala Athletic Identity Measurement Scale-E

2016

ResumenEste estudio pretende determinar las propiedades psicométricas de la Athletic Identity Measurement Scale en su versión traducida al español y la identidad deportiva (ID) de una muestra de adolescentes españoles. El cuestionario se administró a 441 adolescentes de 12-18 años, clasificados en: adolescentes del Programa de Especialización Deportiva (PED), adolescentes no-PED activos y adolescentes no-PED inactivos. El análisis factorial confirmatorio reveló una estructura jerárquica y multidimensional de tres factores de primer orden (identidad social, exclusividad y afectividad negativa) y uno de segundo orden, la ID. Los resultados apoyan la adecuación de los ítems en sus respectivas …

Revista electrónica de investigación y evaluación educativa

2021

Background of INCASI Project H2020-MSCA-RISE-2015 GA 691004. WP1: Compilation Este artículo tiene dos objetivos. En primer lugar, queremos analizar si el peso del origen social de los graduados universitarios influye en la inserción laboral, tomando como indicador los ingresos que obtienen los titulados que trabajan, cuando controlamos la titulación obtenida. En segundo lugar, intentamos observar si los graduados universitarios provenientes de orígenes sociales más desfavorecidos se encuentran más desocupados y más inactivos que los provenientes de hogares con más recursos. Para tal fin analizamos a los titulados que egresaron de universidades públicas catalanas en el curso 2006-2007, entre…

Analysis of tear protein patterns by a neural network as a diagnostical tool for the detection of dry eyes

1999

The electrophoretic patterns of tears from patients with dry-eye disease (n = 43) and from healthy subjects (n = 17) were analyzed by means of multivariate statistical methods and an artificial neural network (ANN), following sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). From each electrophoretic pattern a data set was created, randomly divided into test (unknown samples) and training patterns (known samples), with ANN training by one of these sets. After training, the performance of the ANN was checked by presenting the test data set to the ANN. Furthermore, the data was classified using multivariate analysis of discriminance. The groups were significantly different…