Search results for "mutation."
showing 10 items of 2808 documents
Las matemáticas del cubo de Rubik
2013
[ES] En este artículo mostramos cómo podemos utilizar el cubo de Rubik para presentar algunos conceptos básicos de la teoría de grupos y cómo podemos usar esta para resolver el cubo de Rubik.
Two Simple Constructive algorithms for the Distributed Assembly Permutation Flowshop Scheduling Problem
2014
Nowadays, it is necessary to improve the management of complex supply chains which are often composed of multi-plant facilities. This paper proposes a Distributed Assembly Permutation Flowshop Scheduling Problem (DAPFSP). This problem is a generalization of the Distributed Permutation Flowshop Scheduling Problem (DPFSP) presented by Naderi and Ruiz (Comput Oper Res, 37(4):754–768, 2010). The first stage of the DAPFSP is composed of f identical production factories. Each center is a flowshop that produces jobs that have to be assembled into final products in a second assembly stage. The objective is to minimize the makespan. Two simple constructive algorithms are proposed to solve the proble…
Transmission of Genetic Properties in Permutation Problems: Study of Lehmer Code and Inversion Table Encoding
2021
Solution encoding describes the way decision variables are represented. In the case of permutation problems, the classical encoding should ensure that there are no duplicates. During crossover operations, repairs may be carried out to correct or avoid repetitions. The use of indirect encoding aims to define bijections between the classical permutation and a different representation of the decision variables. These encodings are not sensitive to duplicates. However, they lead to a loss of genetic properties during crossbreeding. This paper proposes a study of the impact of this loss both in the space of decision variables and in that of fitness values. We consider two indirect encoding: the …
Scatter Search vs. Genetic Algorithms
2005
The purpose of this work is to compare the performance of a scatter search (SS) implementation and an implementation of a genetic algorithm (GA) in the context of searching for optimal solutions to permutation problems. Scatter search and genetic algorithms are members of the evolutionary computation family. That is, they are both based on maintaining a population of solutions for the purpose of generating new trial solutions. Our computational experiments with four well-known permutation problems reveal that in general a GA with local search outperforms one without it. Using the same problem instances, we observed that our specific scatter search implementation found solutions of a higher …
Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secreti…
2021
Increasing problems with antibiotic resistance have directed interest toward phage therapy in the aquaculture industry. However, phage resistance evolving in target bacteria is considered a challenge. To investigate how phage resistance influences the fish pathogen Flavobacterium columnare, two wild-type bacterial isolates, FCO-F2 and FCO-F9, were exposed to phages (FCO-F2 to FCOV-F2, FCOV-F5, and FCOV-F25, and FCO-F9 to FCL-2, FCOV-F13, and FCOV-F45), and resulting phenotypic and genetic changes in bacteria were analyzed. Bacterial viability first decreased in the exposure cultures but started to increase after 1 to 2 days, along with a change in colony morphology from original rhizoid to …
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myelo…
2022
Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed substantially, and the outcome for most patients is poor. Thus, continuous efforts on the discovery of new compounds with improved features are required. Following a multistep sequence, we have identified a new tetracyclic ring system with strong antiproliferative activity towards several haematological cell lines. The new compounds possess structural properties typical of inactive-state-binding kinase inhibitors and are structurally related to quizartinib which is known as type-II tyrosine kinase inhibitor. In particular, the high activi…
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation.
2022
Stop mutations cause 11% of the genetic diseases, due to the introduction of a premature termination codon (PTC) in the mRNA, followed by the production of a truncated protein. A promising therapeutic approach is the suppression therapy by Translational Readthrough Inducing Drugs (TRIDs), restoring the expression of the protein. Recently, three new TRIDs (NV848, NV914, NV930) have been proposed, and validated by several in vitro assays, for the rescue of the CFTR protein, involved in Cystic Fibrosis disease. In this work, an acute toxicological study for the three TRIDs was conducted in vivo on mice, according to the OECD No.420 guidelines. Animals were divided into groups and treated with …
Molecular Basis Of Mild Hyperphenylalaninaemia In Turkey
2000
Öz bulunamadı.
Exon deletions of the phenylalanine hydroxylase gene in Italian hyperphenylalaninemics
2009
A consistent finding of many studies describing the spectrum of mutant phenylalanine hydroxylase (PAH) alleles underlying hyperphenylalaninemia is the impossibility of achieving a 100% mutation ascertainment rate using conventional gene-scanning methods. These methods include denaturing gradient gel electrophoresis (DGGE), denaturing high performance liquid chromatography (DHPLC), and direct sequencing. In recent years, it has been shown that a significant proportion of undetermined alleles consist of large deletions overlapping one or more exons. These deletions have been difficult to detect in compound heterozygotes using gene-scanning methods due to a masking effect of the non-deleted al…
Regulation of pteridine biosynthesis and aromatic amino acid hydroxylation in Drosophila melanogaster
1989
The relationship between high dietary levels of aromatic amino acid and regulation of pteridines in Drosophila eyes was examined by measuring changes in pool levels of six pterins in the wild type and mutants and amino acid pool levels in flies that carry mutations for pteridine biosynthesis. The effect upon relative viability and developmental times was also analyzed; relative viability was affected by L-phenylalanine, L-tryptophan, and L-tyrosine in decreasing order and the D-amino acids had little or no effect. The changes in concentration of biopterin, dihydrobiopterin, pterin, sepiapterin, drosopterins, and isoxanthopterin showed a characteristic pattern of increased and/or decreased a…