Search results for "myoclonic epilepsy"

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Alteration of dopamine D2/D3 receptor binding in patients with juvenile myoclonic epilepsy

2010

Summary Purpose: To quantify extrastriatal and striatal D2/D3 receptor binding in patients with juvenile myoclonic epilepsy (JME) using the high-affinity dopamine D2/D3 receptor positron emission tomography (PET) ligand 18F-Fallypride ([18F]FP). Methods: Twelve patients with JME and 21 age-matched control subjects were studied. Dynamic images (180 min) were acquired after injection of [18F]FP. Patients had been seizure-free of all seizure types for at least 10 days before scanning. Parametric images of binding potential (BP) were created using the simplified reference tissue model. The images were stereotactically normalized using a ligand-specific template. We performed a voxel-based ana…

medicine.medical_specialtybusiness.industryPutamenVentral striatumCaudate nucleusmedicine.diseaseTemporal lobemedicine.anatomical_structureEndocrinologynervous systemNeurologyDopamine receptor D3Dopamine receptor D2Internal medicineBasal gangliamedicineNeurology (clinical)Juvenile myoclonic epilepsybusinessEpilepsia

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