Search results for "myopia"
showing 10 items of 165 documents
Implantable collamer lens and femtosecond laser for myopia: comparison using an adaptive optics visual simulator.
2014
Purpose: To compare optical and visual quality of implantable collamer lens (ICL) implantation and femtosecond laser in situ keratomileusis (F-LASIK) for myopia. Methods: The CRX1 adaptive optics visual simulator (Imagine Eyes, Orsay, France) was used to simulate the wavefront aberration pattern after the two surgical procedures for -3-diopter (D) and -6-D myopia. Visual acuity at different contrasts and contrast sensitivities at 10, 20, and 25 cycles/degree (cpd) were measured for 3-mm and 5-mm pupils. The modulation transfer function (MTF) and point spread function (PSF) were calculated for 5-mm pupils. Results: F-LASIK MTF was worse than ICL MTF, which was close to diffraction-limited MT…
Myopic astigmatism correction: comparison of a Toric Implantable Collamer Lens and a bioptics technique by an adaptive optics visual simulator.
2013
Purpose To compare the optical and visual quality of a simulated Toric Implantable Collamer Lens (TICL) and a bioptics technique to treat high myopic astigmatism. Methods An adaptive optics visual simulator was used to simulate the vision after TICL implantation and a bioptics procedure from the wavefront aberration pattern for moderate and high-myopic astigmatism. Visual acuity (VA) at different contrasts and contrast sensitivity (CS) at 10, 20 and 25 cycles degree−1 were measured for 3 and 5-mm pupils. Modulation Transfer Function (MTF) and Point Spread Function (PSF) were calculated for a 5-mm pupil. Results At a 3-mm pupil we only found statistically significant differences in VA betwee…
Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.
2012
Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis study in which we assessed whether these two loci are also associated with myopia in other populations. The study population comprised 31 cohorts from the Consortium of Refractive Error and Myopia (CREAM) representing 4 different continents with 55,177 individuals; 42,845 Caucasians and 12,332 Asians. We performed a meta-analysis of 14 single nucleotide polymorphisms (SNPs) on 15q14 and 5 SNPs on …
Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.
2019
Purpose: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). Methods: A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study. Highly myopic (spherical equivalent [SE] ≤ -5.0 diopters [D]) cases with MMD (N = 348), and two sets of cont…
The effect of fractal contact lenses on peripheral refraction in myopic model eyes.
2014
Purpose: To test multizone contact lenses in model eyes: Fractal Contact Lenses (FCLs), designed to induce myopic peripheral refractive error (PRE). Methods: Zemax ray-tracing software was employed to simulate myopic and accommodation-dependent model eyes fitted with FCLs. PRE, defined in terms of mean sphere M and 90–180 astigmatism J180, was computed at different peripheral positions, ranging from 0 to 35 in steps of 5, and for different pupil diameters (PDs). Simulated visual performance and changes in the PRE were also analyzed for contact lens decentration and model eye accommodation. For comparison purposes, the same simulations were performed with another commercially available conta…
Surgical management of acute angle-closure glaucoma after toric implantable contact lens implantation
2006
A case of pupillary block after implantation of an implantable contact lens (ICL) is reported, and surgical management and prevention are discussed. In a myopic patient, the best corrected visual acuity in the right eye was 20/50 with -15.50 -3.00 x 175. After uneventful implantation of an ICL, painful acute glaucoma developed with an intraocular pressure beyond measurable values. Apparent anterior vaulting of the ICL suggested a sizing problem. In a situation of a mid-wide dilated pupil, immediate explantation of the ICL was performed. Then, using a preoperative iris photography as guidance, an anterior chamber iris-claw toric phakic intraocular lens was implanted. On postoperative examina…
Is Ranibizumab effective in stopping loss of vision secondary to Choroidal Neovascularization in Pathologic Myopia? A Long Term Follow-up Study.
2011
Purpose: To assess the efficacy and safety of Ranibizumab in the treatment of choroidal neovascularization (CNV) caused by pathologic myopia (PM). Design: Prospective, multicenter, interventional case series. Methods: 40 of 39 consecutive patients with PM and CNV were treated with “on-demand” intravitreal injection of ranibizumab 0.5 mg. Final best-corrected VA (BCVA) and its change from baseline were the main outcome measures. Changes in Optical Coherence Tomography (OCT) central retinal thickness (CRT) were a secondary outcome. Results: Mean age was 53 ± 13 years, mean refractive error -13.5 ± 6.5 diopters. Median follow-up was 13.3 ± 2 months (range 12 – 18). Fifteen eyes (37.5%) had pre…
Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia
2021
Purpose: Emmetropization requires coordinated scaling of the major ocular components, corneal curvature and axial length. This coordination is achieved in part through a shared set of genetic variants that regulate eye size. Poorly coordinated scaling of corneal curvature and axial length results in refractive error. We tested the hypothesis that genetic variants regulating eye size in emmetropic eyes are distinct from those conferring susceptibility to refractive error. Methods: A genome-wide association study (GWAS) for corneal curvature in 22,180 adult emmetropic individuals was performed as a proxy for a GWAS for eye size. A polygenic score created using lead GWAS variants was tested fo…
Ortokeratoloģijas lēcas dizaina ietekme uz acs aksiālā garuma izmaiņām.
2020
Maģistra darbs ir uzrakstīts angļu valodā uz 59 lapaspusēm. Tas satur 24 attēlus, 3 tabulas un 85 literatūras atsauces. Pētījuma mērķis bija novērtēt miopijas kontroles ortokeratoloģijas lēcu formas un optiskās zonas platuma ietekmi uz miopijas progresijas mazināšanu. Darbā tika analizēti 12 bērnu ar augstu miopijas pakāpi ortokeratoloģijas rezultāti, iegūti kopā no 19 acīm. Tika salīdzinātas acs aksiālā garuma izmaiņas, bērniem nēsājot parastas ortokeratoloģijas lēcas un lietojot specializētās miopijas kontroles ortokeratoloģijas lēcas. Rezultāti parādīja, ka specializētās ortokerotoloģijas lēcas daudz efektīvāk samazina acs aksiālā garuma palielināšanos nekā parastās lēcas. Atslēgas vārdi…
Sintonikas ietekme uz miopiju
2017
MĒRĶIS: noteikt sintonikas fototerapijas efektivitāti jauniešiem ar vidējās pakāpes miopiju līdz 3,0D vai nekoriģēto sākotnējo miopiju. METODE: 10 miopi vecumā no 8 līdz 17 gadi. Tika izmantotāss redzes asuma, miopijas pakāpes, akomodācijas amplitūdas, acs zīlītes αω reakcijas un redzes lauka noteikšanas testi. Pēc sākotnējās pārbaudēs dalībnieki tika pakļauti 15 sintonikas seansiem. REZULTĀTI: pēc sintonikas pielietošanas statistiski nozīmīgi uzlabojas akomodācijas amplitūda, redzes asums, acs zīlītes reakcijas - αω un redzes lauks. Tika novērots miopijas samazinājums3 dalībniekiem ar sākotnējo miopiju un nozīmīga uzlabošanas parējiem 4 dalībniekiem. SECINĀJUMI: Statistiski nozīmīgi rezult…