Search results for "nanocapsule"

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Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing th…

2015

Enhancing delivery of antigens to dendritic cells (DCs) is essential for the induction of vigorous antigen-specific cellular immune responses. Aim of the present study was to evaluate the properties of hydroxyethyl starch nanocapsules (HES-NCs) functionalized with anti-CD40, anti-DEC205, interferon-γ (IFNγ) and/or monophosphoryl lipid A (MPLA) with respect to the overall uptake, the released cytokine profile, and the influence on phenotypic maturation of human monocyte-derived DCs using flow cytometry, confocal microscopy and enzyme-linked immunosorbent assays. NC uptake by DCs was significantly enhanced by functionalizing NCs with anti-CD40 or MPLA. With respect to the cytokine profile and…

medicine.medical_treatmentMonophosphoryl Lipid ANanocapsulesFlow cytometryHydroxyethyl Starch DerivativesImmune systemAntigenAdjuvants ImmunologicNanocapsulesInterferonmedicineHumansCells CulturedMicroscopy ConfocalGeneral VeterinaryGeneral Immunology and Microbiologymedicine.diagnostic_testChemistryPublic Health Environmental and Occupational HealthDendritic CellsTh1 CellsInterleukin-12Cell biologyToll-Like Receptor 4Infectious DiseasesLipid ANanomedicineBiochemistryMolecular MedicineAdjuvantCD80medicine.drugVaccine

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LSLife Sciences
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