Search results for "nap"
showing 10 items of 2226 documents
Maties Mercader, Pratica de citreria (1475) : Edició crítica. Introducció i notes
2014
Treballem sobre un manuscrit del s.XV escrit per Maties Mercader, canonge de la catedral de València nascut a principis del s.XV i mort el 1489 a la mateixa ciutat. Les seues restes reposen a la catedral. El manuscrit està datat el 1475 a la ciutat de Nàpols. Mercader, germà i fill de batlles de València, va ser a la cort del rei Ferran, fill d’Alfons el Magnànim, on aquell li encomanà un treball sobre la pràctica que ell mateix havia experimentat en la cura d’ocells de caça. Mercader era aficionat a aquesta modalitat de caça i l’havia exercida acompanyant el mateix rei Ferran. Obeint el dictamen del rei, la seua experiència en la cura d’ocells ve recollida en aquest preciós còdex de quaran…
Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures
2015
We are pleased to note that our publication “Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures” by Weir et al. (2015) raised some discussion on the feasibility of solely electrophysiological discrimination of distinct neuronal subpopulations in vitro. We agree with Becchetti and Wanke (2015) that their report and our study on the same question were conducted with different technical approaches and that this may explain the observed differences between both studies. Although we obviously recorded a reduced spontaneous neuronal activity under our sparse culture conditions, these conditions were necessary to enable the uneq…
Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice
2012
[EN] The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity index was evaluated, and a histologic study was carried out. Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools. The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the…
A History of the Pharmacological Treatment of Bipolar Disorder.
2018
In this paper, the authors review the history of the pharmacological treatment of bipolar disorder, from the first nonspecific sedative agents introduced in the 19th and early 20th century, such as solanaceae alkaloids, bromides and barbiturates, to John Cade’s experiments with lithium and the beginning of the so-called “Psychopharmacological Revolution” in the 1950s. We also describe the clinical studies and development processes, enabling the therapeutic introduction of pharmacological agents currently available for the treatment of bipolar disorder in its different phases and manifestations. Those drugs include lithium salts, valproic acid, carbamazepine, new antiepilep…
Dallo «spaesamento» alla «smarginatura». Echi ortesiani nell’Amica geniale
2019
Nel microcosmo narrativo della tetralogia inaugurata dall’Amica geniale di Elena Ferrante si dispiega variamente orchestrata, una sorta di sintassi compositiva in cui agisce, senza forzature o dirette filiazioni, l’eco dell’esperienza artistica di Anna Maria Ortese, in particolare delle modalità con cui l’autrice del Mare non bagna Napoli incarna nell’affresco generazionale, nelle cartografie sociali ed epocali, il vorticare complesso e misterioso delle “relazioni umane nel mondo”con il suo groviglio di istinto e ragione, protervia e martirio, abbrutimento e riscatto. E' racchiusa nella nozione straniante di "smarginatura", centrale nell'invenzione narrativa della Ferrante, una pulsione del…
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
2002
In rats, exposure to diazepam (DZ) during the last week of gestation is associated with behavioral alterations (in some cases sexually dimorphic) that appear when the animals reach adulthood. This study was conducted to evaluate the effects of prenatal DZ exposure on the function of the gamma-aminobutyric (GABA)(A) receptor complex. The method used - perfusion of rat hippocampal nerve terminals labeled with [3H]noradrenaline (NA) - allowed us to evaluate the effects of DZ on a specific native GABA(A) receptor subtype which is located on hippocampal noradrenergic nerve endings and mediates the release of NA. Muscimol stimulated synaptosomal release of [3H]NA in a concentration-dependent mann…
Tra economia, politica e società: la “questione feudale” nei regni di Napoli e di Sicilia nel XVIII secolo
2015
La "questione feudale" consistette in un ampio e articolato dibattito sulle forme della politica, sulla società e sull'economia che interessò i regni di Napoli e di Sicilia nel XVIII secolo.
Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior.
2014
Dendrites are highly complex 3D structures that define neuronal morphology and connectivity and are the predominant sites for synaptic input. Defects in dendritic structure are highly consistent correlates of brain diseases. However, the precise consequences of dendritic structure defects for neuronal function and behavioral performance remain unknown. Here we probe dendritic function by using genetic tools to selectively abolish dendrites in identified Drosophila wing motoneurons without affecting other neuronal properties. We find that these motoneuron dendrites are unexpectedly dispensable for synaptic targeting, qualitatively normal neuronal activity patterns during behavior, and basic …
Steam catalytic cracking of naphtha over ZSM-5 zeolite for production of propene and ethene: Micro and macroscopic implications of the presence of st…
2012
One option to produce more ethene and propene can be to crack naphtha type fractions in dedicated smaller FCC units. We present here the results obtained for high temperature steam catalytic cracking (SCC) of a representative naphtha product (n-heptane) with ZSM-5. It has been found that under those conditions the presence of steam produces an irreversible dealumination of the zeolite as well as a reversible deactivation due to the interaction of water with active sites with a negative effect on protolytic cracking. A kinetic decay model that takes into account the two phenomena has been developed. The apparent activation energy is lower in the presence of steam. It appears that whilst the …
Hard Cap Espresso Machines in Analytical Chemistry: What Else?
2016
A hard cap espresso machine has been used in combination with liquid chromatography with molecular fluorescence detection for the determination of polycyclic aromatic hydrocarbons (PAHs) from contaminated soils and sediments providing appropriate extraction efficiencies and quantitative results. Naphthalene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benz[a]anthracene, chrysene, benz[b]fluoranthene, benz[k]fluoranthene, benz[a]pyrene, dibenz[a,h]anthracene, benz[ghi]perylene, and indeno[1,2,3-cd]pyrene were used as target compounds. It should be mentioned that the pairs benz[a]anthracene-chrysene and dibenz[a,h]anthracene-benz[ghi]perylene peaks coelute under th…