Search results for "napA"

showing 3 items of 33 documents

Tenapanor for the treatment of irritable bowel syndrome with constipation.

2020

Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …

safetymedicine.medical_specialtyFunctional impairmentConstipationmedicine.medical_treatmentefficacyLaxative030226 pharmacology & pharmacyGastroenterologyIrritable Bowel Syndrome03 medical and health scienceschemistry.chemical_compound0302 clinical medicineGastrointestinal AgentsInternal medicinemedicineAnimalsHumansPharmacology (medical)Pharmacologic therapyDrug InteractionsGeneral Pharmacology Toxicology and PharmaceuticsTenapanorIrritable bowel syndromeSulfonamidesbusiness.industrySodium-Hydrogen Exchanger 3General Medicinemedicine.diseaseIsoquinolinestenapanor.chemistry030220 oncology & carcinogenesismedicine.symptombusinessConstipationExpert review of clinical pharmacology
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Russkoe slovesnoe udarenie v reči finskih gimnazistov

2013

Tutkin pro gradu -tutkielmassani venäjän sanapainoa viiden suomalaisen abiturientin puheessa. Tutkimuksessani keskityn sanapainoon, painollisiin ja painottomiin vokaaleihin sekä niiden reduktioon. Työssäni käytän tutkimusmenetelmänä viiden venäjänkielisen informantin tekemää auditiivista arviointia suomalaisten ääntämisestä, mihin työni analyysi pohjautuu. Tutkimuskysymyksiä ovat: mitkä vokaalit, painolliset ja painottomat, tuottavat eniten vaikeuksia abiturienteille, miten sanapainon paikka vaikuttaa abiturienttien lausumiseen ja millaisia eroja yksittäisten abiturienttien lausumisessa on? Teoriaosuudessa pääpaino on venäjän sanapainolla, mutta vertailen myös suomen sanapainoa venäjän sana…

sanapainovokaalitfonetiikkavenäjän kielikielen oppiminen
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Oltre la tutela della frontiera: l'attività di disciplina e vigilanza su produzioni e coltivazioni della Suprema Generale Deputazione di Salute Pubbl…

2017

La Suprema Deputazione di Salute Pubblica del Regno di Sicilia dedicò una parte della sua attività a vigilare su alcune coltivazioni e produzioni che si ritenevano causa di patologie

sanitàlinosanità; Sicilia; ambiente; territorio; miasmi; paludi; lino; canapa; sodasodaSiciliapaludiambientecanapaterritoriomiasmi
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