Search results for "neonatal"

showing 10 items of 581 documents

Neonatal sepsis caused by Ralstonia pickettii

2008

e describe the clinical case of apremature newborn, born at 26weeks by cesarean delivery, followed inthe neonatal intensive care unit. Themother was diabetic with adequate con-trol during pregnancy.Neonatal weight was 930 g;APGAR score 3 at 1 minute and 8 at 5minutes. She received forced ventilationby endotracheal tube and parenteralnutrition by a central venous catheter.She was treated with ampicillin for thefirst 20 days of life. At 25 days, apneaand bradychardia episodes occurredwith a progressive increment in sever-ity and frequency. Leukocytes, C-re-active protein, cerebral echography,and echocardiogram were normal.Oralfeeding was transiently stopped and rani-tidine treatment was starte…

MaleMicrobiology (medical)medicine.medical_specialtyNeonatal intensive care unitSettore MED/42 - Igiene Generale E ApplicataSepsisPregnancySepsisAmpicillinHumansMedicineNosocomial infections NICU Ralstonia pickettiiCesarean deliveryRalstonia pickettiiPregnancyNeonatal sepsisbiologybusiness.industryRalstonia pickettiiInfant Newbornmedicine.diseasebiology.organism_classificationSurgeryInfectious DiseasesAnesthesiaPediatrics Perinatology and Child HealthFemaleApgar scoreGram-Negative Bacterial Infectionsbusinessmedicine.drug
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Paternal symptoms of anxiety and depression in the first month after childbirth: A comparison between fathers of full term and preterm infants

2020

Abstract Background Although men have a higher risk of developing a mental disorder during the perinatal period, few studies have focused on new fathers’ mental health screening. This study compares anxiety and depression symptoms between fathers with newborn infants in the neonatal intensive care unit (NICU) and fathers of healthy full-term infants, assessing the impact of stress caused by the NICU.. Methods A longitudinal and prospective study with control (n= 33) and study groups (n=51) was designed. The dependent variables assessed were post-natal depression and anxiety-state while the social and demographic information, health background and the parental stress in the neonatal unit wer…

MaleNeonatal intensive care unitMothersAnxietyFathers03 medical and health sciences0302 clinical medicinePregnancymedicineHumansChildbirthProspective StudiesProspective cohort studyDepression (differential diagnoses)Full TermDepressionbusiness.industryInfant NewbornInfantMental health030227 psychiatryPsychiatry and Mental healthClinical PsychologyAnxietyFemalemedicine.symptombusinessHealthcare providersInfant Premature030217 neurology & neurosurgeryClinical psychologyJournal of Affective Disorders
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Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity.

2004

International audience; Thoracic aortic aneurysm and aortic dissection (TAA and AD) are an important cause of sudden death. Familial cases could account for 20% of all cases. A genetic heterogeneity with two identified genes (FBN1 and COL3A1) and three loci (3p24-25 or MFS2/TAAD2, 5q13-q14 and 11q23.2-24) has been shown previously. Study of a single family composed of 179 members with an abnormally high occurrence of TAA/AD disease. A total of 40 subjects from three generations were investigated. In addition to five cases of stroke and three cases of sudden death, there were four cases of AD and four cases of TAA in adults. In all, 11 cases of patent ductus arteriosus (PDA) were observed, t…

MalePathologymedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesGenetic Linkage030204 cardiovascular system & hematologyThoracic aortic aneurysmSudden deathFamilial thoracic aortic aneurysm03 medical and health sciencesAortic aneurysmDeath Sudden0302 clinical medicineDuctus arteriosusGenetic modelGeneticsmedicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingHumansDuctus Arteriosus PatentGenetics (clinical)030304 developmental biologyAortic dissection0303 health sciences[ INFO.INFO-IM ] Computer Science [cs]/Medical ImagingAortic Aneurysm ThoracicGenetic heterogeneitybusiness.industryAnatomymedicine.disease3. Good healthPedigreeStrokeAortic Dissectionmedicine.anatomical_structureFemaleFrancebusinessMicrosatellite RepeatsEuropean journal of human genetics : EJHG
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Clinical features and follow-up in patients with 22q11.2 deletion syndrome

2014

Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In…

MalePediatrics22q11.2 deletionDelayed DiagnosisTime FactorsChromosomes Human Pair 22Developmental Disabilitiesdigeorge syndromeSex FactorSeverity of Illness IndexRetrospective StudieDiGeorge syndromeEarly DiagnosiAge FactorProspective StudiesNeonatal hypocalcemiaProspective cohort studyChildmedicine.diagnostic_testDelayed Diagnosi22q11.2 deletion; Primary immune disordersAge Factorsdel 22qMIMAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease ProgressionChild PreschoolCohortDisease ProgressionPrimary immune disordersFemaleAbnormalitiesMultipleAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease Progression; Pediatrics Perinatology and Child HealthHumanAdultmedicine.medical_specialtyTime FactorAdolescentMonitoringDevelopmental DisabilitieItalian Association of Pediatric Haematology and OncologyContext (language use)Risk AssessmentChromosomesFollow-Up StudieYoung AdultSex FactorsSeverity of illnessmedicineDiGeorge SyndromeHumansAbnormalities MultipleGenetic Testing22q11DS; 22q11.2 deletion syndrome; AIEOP; Italian Association of Pediatric Haematology and Oncology; MIM; Mendelian Inheritance in Man22q11DSPreschoolPhysiologicdigeorge syndrome; del 22qGenetic testingMonitoring PhysiologicRetrospective StudiesSettore MED/38 - Pediatria Generale e Specialisticabusiness.industryMendelian Inheritance in ManInfant NewbornInfantRetrospective cohort studymedicine.diseaseNewbornAIEOPProspective StudieEarly Diagnosis22q11.2 deletion syndromePediatrics Perinatology and Child HealthPair 22businessFollow-Up Studies
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EAU Guidelines on Vesicoureteral Reflux in Children

2012

Context: Primary vesicoureteral reflux (VUR) is a common congenital urinary tract abnormality in children. There is considerable controversy regarding its management. Preservation of kidney function is the main goal of treatment, which necessitates identification of patients requiring early intervention.Objective: To present a management approach for VUR based on early risk assessment.Evidence acquisition: A literature search was performed and the data reviewed. From selected papers, data were extracted and analyzed with a focus on risk stratification. The authors recognize that there are limited high-level data on which to base unequivocal recommendations, necessitating a revisiting of thi…

MalePediatricsACID SCINTIGRAPHYmedicine.medical_treatmentKidneyurologic and male genital diseasesPediatricsVOIDING CYSTOURETHROGRAPHYURETERAL REIMPLANTATIONMedicineAntibiotic prophylaxisFamily historyChildChildrenNEONATAL HYDRONEPHROSISReimplantationUrinary tract infectionVesicoureteral refluxDiagnostic Techniques Urologicalfemale genital diseases and pregnancy complicationsAnti-Bacterial AgentsTreatment OutcomeRenal scarringBulking agentsEAUPREDICTIVE FACTORSChild PreschoolPredictive value of testsUrologic Surgical ProceduresFemaleRisk assessmentmedicine.medical_specialtyUrologyUrinary systemContext (language use)GuidelinesVesicoureteral refluxURINARY-TRACT-INFECTIONANTIBIOTIC-PROPHYLAXISPredictive Value of TestsHumansWatchful WaitingVesico-Ureteral RefluxProphylaxisbusiness.industryInfantEndoscopymedicine.diseaseVURSurgeryISOLATED ANTENATAL HYDRONEPHROSISEarly DiagnosisRENAL DAMAGESPONTANEOUS RESOLUTIONLaparoscopybusinessWatchful waitingEuropean Urology
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Etiological heterogeneity and clinical variability in newborns with esophageal atresia

2018

Abstract Background The aim of this study was to define different characteristics of infants with esophageal atresia and correlations with neonatal level of care, morbidity and mortality occurring during hospital stay. Methods Charts of all newborns with esophageal atresia (EA) admitted to our University NICU between January 2003 and November 2016 were reviewed and subdivided in four groups related to different clinical presentations; EA as an isolated form (A), with a concomitant single malformation (B), as VACTERL association (C), and in the context of a syndrome or an entity of multiple congenital anomalies (D). Results We recruited 67 infants with EA (with or without tracheoesophageal f…

MalePediatricsDatabases FactualAnal CanalTracheoesophageal fistulaKidneyCohort StudiesVACTERL association0302 clinical medicineMedicine030212 general & internal medicineHospital Mortalitylcsh:RJ1-570General MedicinePrognosisVACTERL associationTracheaRetrospective studyFemaleNeonatal intensive careRetrospective study Esophageal atresia VACTERL association Neonatal intensive care NewbornHeart Defects Congenitalmedicine.medical_specialtyLimb Deformities CongenitalContext (language use)Gestational AgeRisk Assessment03 medical and health sciencesEsophagus030225 pediatricsIntensive careIntensive Care Units NeonatalHumansAbnormalities MultipleGenetic Predisposition to DiseaseRetrospective Studiesbusiness.industryResearchInfant NewbornRetrospective cohort studylcsh:PediatricsLength of Staymedicine.diseaseNewbornSurvival AnalysisSpineParenteral nutritionAtresiaEsophageal atresiaEtiologybusiness
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Perfusion Index and Pulse Oximetry Screening for Congenital Heart Defects

2017

Objective To evaluate the efficacy of combined pulse oximetry (POX) and perfusion index (PI) neonatal screening for severe congenital heart defects (sCHD) and assess different impacts of screening in tertiary and nontertiary hospitals. Study design A multicenter, prospective study in 10 tertiary and 6 nontertiary maternity hospitals. A total of 42 169 asymptomatic newborns from among 50 244 neonates were screened; exclusion criteria were antenatal sCHD diagnosis, postnatal clinically suspected sCHD, and neonatal intensive care unit admission. Eligible infants underwent pre- and postductal POX and PI screening after routine discharge examination. Targeted sCHD were anatomically defined. Posi…

MalePediatricsNeonatal intensive care unit030204 cardiovascular system & hematologyPediatricsSeverity of Illness IndexHypoplastic left heart syndromeCohort StudiesTertiary Care CentersCongenital0302 clinical medicineNeonatalOximetryProspective StudiesProspective cohort studyHeart Defectsmedicine.diagnostic_testIncidenceIncidence (epidemiology)Perinatology and Child Healthcongenital heart defectsHospitalspulse oximetrycongenital heart defects; neonatal screening; perfusion index; pulse oximetry; Blood Gas Analysis; Cohort Studies; Heart Defects Congenital; Hospitals Maternity; Humans; Incidence; Infant Newborn; Intensive Care Units Neonatal; Italy; Male; Neonatal Screening; Oximetry; Oxygen Consumption; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Tertiary Care Centers; Pediatrics Perinatology and Child HealthIntensive Care UnitsItalymedicine.symptomCohort studyHeart Defects Congenitalmedicine.medical_specialtyMaternityHospitals MaternityRisk AssessmentSensitivity and SpecificityAsymptomatic03 medical and health sciencesNeonatal ScreeningOxygen ConsumptionIntensive Care Units Neonatal030225 pediatricsSeverity of illnessmedicineHumansperfusion indexbusiness.industryInfant NewbornInfantNewbornmedicine.diseasePulse oximetryPediatrics Perinatology and Child HealthBlood Gas AnalysisbusinessThe Journal of Pediatrics
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Routine Probiotic Use in Very Preterm Infants: Retrospective Comparison of Two Cohorts

2013

International audience; OBJECTIVE: Evidence supports the efficacy of probiotics in reducing necrotizing enterocolitis (NEC) in very low-birth-weight infants, although concerns remain with regard to their routine use. Since 2008 in our neonatal intensive care unit, a low dose of probiotics (unique strain) is administered as standard of care in all preterm babies born at 24 to 31 weeks' gestation. This study reports outcomes in infants receiving probiotic cohort (PC) compared with the historical cohort. DESIGN: Treatment with Lactobacillus rhamnosus Lcr35 (Lcr Restituo) (2 × 108 colony-forming units/12 h) was started early after birth and intention to treat was up to 36 weeks' gestation. The …

MalePediatricsTime FactorsNeonatal intensive care unit[ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/PediatricsEnteral administration0302 clinical medicineNeonatalOdds RatioInfant Very Low Birth Weight030212 general & internal medicineLacticaseibacillus rhamnosusStatisticsObstetrics and GynecologyGestational age3. Good healthCohortNecrotizing enterocolitisFemaleGastrointestinal Hemorrhagemedicine.medical_specialtyGestational AgeStatistics Nonparametric03 medical and health sciencesEnterocolitis NecrotizingSepsis030225 pediatricsIntensive careConfidence IntervalsmedicineHumansLactobacillus rhamnosusNonparametricRetrospective Studies[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/PediatricsAnalysis of VarianceEnterocolitisbusiness.industryVery Low Birth WeightProbioticsInfant NewbornIntensive CareInfantRetrospective cohort studyOdds ratioNewbornmedicine.diseasePediatrics Perinatology and Child HealthIntensive Care NeonatalNecrotizingbusinessAmerican Journal of Perinatology
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Newborn screening and disease variants predict neurological outcome in isovaleric aciduria.

2021

Isovaleric aciduria (IVA), a metabolic disease with severe (classic IVA) or attenuated phenotype (mild IVA), is included in newborn screening (NBS) programs worldwide. The long-term clinical benefit of screened individuals, however, is still rarely investigated. A national, prospective, observational, multi-center study of individuals with confirmed IVA identified by NBS between 1998 and 2018 was conducted. Long-term clinical outcomes of 94 individuals with IVA were evaluated, representing 73.4% (for classic IVA: 92.3%) of the German NBS cohort. In classic IVA (N = 24), NBS prevented untimely death except in one individual with lethal neonatal sepsis (3.8%) but did not completely prevent si…

MalePediatricsmedicine.medical_specialtyAdolescentNeurocognitive DisordersDisease03 medical and health sciencesYoung AdultCognitionNeonatal ScreeningMaintenance therapyGermanyGeneticsmedicineHumansProspective StudiesMetabolic diseaseChildAmino Acid Metabolism Inborn ErrorsGenetics (clinical)030304 developmental biology0303 health sciencesNewborn screeningNeonatal sepsisIsovaleryl-CoA Dehydrogenasebusiness.industry030305 genetics & heredityInfant NewbornInfantmedicine.diseasePrognosisIsovaleric AcidemiaPhenotypeChild PreschoolCohortFemalesense organsbusinessNeurocognitiveJournal of inherited metabolic diseaseREFERENCES
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Skeletal abnormalities of the upper limbs--neonatal diagnosis of 49,XXXXY syndrome.

2012

A case of neonatal diagnosis of 49,XXXXY syndrome is presented. Clinical identification was prompted by a bilateral thickening of the radioulnar joints and X-ray imaging disclosing almost complete radioulnar synostosis. Conventional karyotyping was initiated and revealed a karyotype of 49,XXXXY. Previously reported neonatal symptoms such as low birth weight, muscular hypotonia, or genital malformations were absent in this case. Microsatellite analysis showed two different X chromosomes each present in two copies, supporting that the four X chromosomes had arisen from a nondisjunction in maternal meiosis I followed by a second nondisjunction involving both X chromosomes in meiosis II. Multid…

MalePediatricsmedicine.medical_specialtyBiologyUpper ExtremityNeonatal ScreeningMeiosisGeneticsmedicineHumansAbnormalities MultipleMuscle SkeletalX chromosomeChromosomes Human XMuscular hypotoniaMeiosis IIInfant NewbornKaryotypeGeneral MedicineAnatomySyndromemedicine.diseaseLow birth weightNondisjunction49 XXXXY syndromemedicine.symptomGene
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