Search results for "nested case-control study"

showing 4 items of 14 documents

Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

2017

Background: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease duri…

Malecompuestos de metilmercurioTime Factorsmodelos logísticosMediterranean diethumanos030204 cardiovascular system & hematologyDiet MediterraneanRecommended Dietary AllowancesDieta mediterrània1471-22610302 clinical medicineRisk Factorsestudios prospectivosevaluación de riesgosOdds RatioOily fishWater Pollutants030212 general & internal medicineProspective StudiesToenail biomarkeruñasmediana edadCiències de la salutAged 80 and overeducation.field_of_studyBioquímica y tecnologíaanciano:Ciencias de la Salud::Salud pública [Materias Investigacion]dietaMALALTIES CARDIOVASCULARSMethylmercury CompoundsMiddle Agedcontaminantes del aguaCardiovascular diseaseCiencias de la saludcociente de probabilidades relativasBiochemistry and technologyCardiovascular DiseasesBody BurdenFemaleCardiology and Cardiovascular Medicinecantidad dietética recomendadaResearch ArticlePREDIMEDmedicine.medical_specialtyPopulationestudios de casos y controlesenfermedades cardiovasculareschemistry.chemical_elementFood ContaminationSistema cardiovascular malaltiesBioquímica i biotecnologiaRisk Assessment03 medical and health sciencesalimentos del marfactores de tiempoEnvironmental healthMediterranean dietmedicineHumansfactores de riesgoMercuri -- Toxicologiaanálisis multifactorialeducationCardivascular diseaseAgedbusiness.industryCase-control studyHealth sciencesOdds ratioMercuryProtective FactorsSurgeryMercury (element)DietLogistic ModelsFishchemistrySeafoodNailsSpainRelative riskCase-Control StudiesNested case-control studyMultivariate AnalysisbusinessWater Pollutants Chemicalcarga corporal
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Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures

2012

There is evidence that the use oral bisphosphonates can lead to osteronecrosis of the jaws (ONJ). Although the occurrence of ONJ appears rare among oral bisphosphonates (BPs) users, it is important to know that it exists and can be opportunely minimized. INTRODUCTION: The purpose of this study is to evaluate the association between BPs prescribed for the secondary prevention of osteoporotic fractures and the occurrence of ONJ. METHODS: An Italian record linkage claims database with a target population of around 18 million individuals (6 million over 55 years of age) constituted the data source. We conducted a nested case-control study within a cohort of individuals aged 55+ years old, who w…

Malemedicine.medical_specialtyEndocrinology Diabetes and MetabolismONJDentistryOsteoporosis; fractures; biphosphonatesAdministration OralBisphosphonates Nested case–control study Osteonecrosis of the jaw Osteoporotic fracturesOSTEPOROSISRisk AssessmentAssociationADMINSTRATIVE DATABASESnested case-control studySettore MED/28 - Malattie OdontostomatologicheClaims dataMedicineHumansnested case-control study; osteoporotic fractures; osteonecrosis of the jaw; bisphosphonatesWomenbisphosphonatesAgedSecondary preventionAged 80 and overOral bisphosphonatesBone Density Conservation AgentsDiphosphonatesbusiness.industryMiddle Agedmedicine.diseaseOral BisphosphonateNecrosiosteonecrosis of the jawItalyClaims DataCase-Control StudiesOrthopedic surgeryBisphosphonates; Osteonecrosis of the jaw; Osteoporotic fractures; Nested case-control studyBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryProfileBisphosphonate therapyMedical Record LinkagebusinessOsteonecrosis of the jawOsteoporotic Fractures
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2021

Background Therapy for a first primary neoplasm (FPN) in childhood with high doses of ionizing radiation is an established risk factor for second primary neoplasms (SPN). An association between exposure to low doses and childhood cancer is also suggested; however, results are inconsistent. As only subgroups of children with FPNs develop SPNs, an interaction between radiation, genetic, and other risk factors is presumed to influence cancer development. Objective Therefore, the population-based, nested case-control study KiKme aims to identify differences in genetic predisposition and radiation response between childhood cancer survivors with and without SPNs as well as cancer-free controls.…

Oncologymedicine.medical_specialtybusiness.industryGeneral MedicineAnthropometryInternal medicineNested case-control studyEpidemiologyGenetic predispositionMedicineObservational studyCopy-number variationRisk factorFamily historybusinessJMIR Research Protocols
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Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk

2020

Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been investigated comprehensively. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial in which participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched …

high-density lipoproteinsMalemedicine.medical_specialtyAcute coronary syndromePopulationDysfunctional familyDisease030204 cardiovascular system & hematologyDiet Mediterraneanacute coronary syndrome03 medical and health scienceschemistry.chemical_compound0302 clinical medicineSphingosineHDL cholesterolPhysiology (medical)Internal medicinemedicineHumans030212 general & internal medicineHigh-density lipoproteinseducationAgededucation.field_of_studyApolipoprotein A-ICholesterolbusiness.industryIncidence (epidemiology)Middle Agedmedicine.diseasechemistryCase-Control StudiesNested case-control studyCardiologyFemalelipids (amino acids peptides and proteins)Acute coronary syndromeLysophospholipidsLipoproteins HDLCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesLipoproteinCirculation
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