Search results for "neurological"
showing 10 items of 393 documents
Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress
2020
Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to …
Post-acute COVID-19 neurological syndrome: a new medical 2 challenge
2021
In December 2019, inWuhan (China), a highly pathogenic coronavirus, named SARS-CoV-2, dramatically emerged. This new virus, which causes severe pneumonia, is rapidly spreading around the world, hence it provoked the COVID-19 pandemic. This emergency launched by SARS-CoV-2 also had, and still has, devastating socio-economic aspects. Assessing the impact of COVID-19 on vulnerable groups of people is crucial for the adaptation of governments' responses. Growing scientific evidence suggests that it is essential to keep the attention on people after acute SARSCoV- 2 infection; indeed, some clinical manifestations are frequently present even after recovery. There is consensus on the need to defin…
Cognitive impairment associated with chronic lead exposure in adults
2018
Abstract Lead (Pb) exposure interferes with many biochemical events present in cells of the central nervous system (neurons and astrocytes) and it can produce a wide spectrum of alterations including cognitive impairment. The review summarizes the main cognitive alterations induced by chronic Pb exposure in adults/older individuals. We have focused on the current state of knowledge concerning the most vulnerable brain areas to Pb exposure that accompanied by the long-lasting neurological effects of Pb in cognitive functions. We tried to correlate the cognitive deficits induced by Pb exposure in animal models during adulthood with those reported in humans. The great interest in whether expos…
Cognitive Deficits and Associated ERP N400 Abnormalities in FXTAS With Parkinsonism
2018
Objective: To examine cognitive deficits and associated brain activity in fragile X-associated tremor/ataxia syndrome (FXTAS) patients with parkinsonism (FXTp+), in relation to FXTAS patients without parkinsonism (FXTp-), and normal elderly controls (NC). Methods: Retrospective reviews were performed in 65 FXTAS patients who participated in the event-related brain potential (ERP) study and also had either a videotaped neurological examination or a neurological examination for extrapyramidal signs. Parkinsonism was defined as having bradykinesia with at least one of the following: rest tremor, postural instability, hypermyotonia, or rigidity. Eleven FXTp+ patients were identified and compare…
CHANGING PERSPECTIVE ON PERCEPTION PHYSIOLOGY: CAN YOU REALLY SEE WHAT IS HAPPENING?
2018
Perception is a complex, neural mechanism that requires organization and interpretation of input meaning and it has been a key topic in medicine, neuroscience and philosophy for centuries. Gestalt psychology proposed that the underlying mechanism is a constructive process that depends on both input of stimuli and the sensory-motor state of the agent. The Bayesian Brain hypothesis reframed it as probabilistic inference of previous beliefs, which are revised to accommodate new information. The Predictive Coding Theory proposes that this process is implemented through a top-down cascade of cortical predictions of lower level input and the concurrent propagation of a bottom-up prediction error …
CHANGING PERSPECTIVE ON PERCEPTION PHYSIOLOGY: CAN YOU REALLY SEE WHAT IS HAPPENING?
2018
Perception is a complex, neural mechanism that requires organization and interpretation of input meaning and it has been a key topic in medicine, neuroscience and philosophy for centuries. Gestalt psychology proposed that the underlying mechanism is a constructive process that depends on both input of stimuli and the sensory-motor state of the agent. The Bayesian Brain hypothesis reframed it as probabilistic inference of previous beliefs, which are revised to accommodate new information. The Predictive Coding Theory proposes that this process is implemented through a top-down cascade of cortical predictions of lower level input and the concurrent propagation of a bottom-up prediction error …
Questions and controversies in the study of time-varying functional connectivity in resting fMRI.
2020
The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain’s functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as “dynamic” or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to re…
Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
2011
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…
Genetic features of neuroblastic tumors associated with opsoclonus-myoclonus syndrome opens up the possibility for detection in peripheral blood
2016
Opsoclonus–myoclonus syndrome (OMS) is a rare paraneoplastic, postinfectious, or parainfectious or idiopathic acute neurological syndrome in children and adults. OMS is characterized by involuntary...
Color induction via non-opponent lateral interactions in the human retina
1992
Retinal connections causing colors in Benham's top (pattern induced flicker colors, PIFCs) are investigated by psychophysical experiments. PIFCs are still seen when stimuli to different cones are demodulated selectively, indicating the involvement of non-opponent channels. PIFCs also occur on retinal areas next to those affected by modulated stimuli; further, both monochromat and dark-adapted trichromats perceive PIFCs which are achromatic. These additional findings point to horizontal cells as neuronal mediators of modulated excitation leading to PIFCs. The unspecifity of the postulated connection with respect to cone types agrees with anatomic findings of Boycott, B. B., Hopkins, J. M. an…