Search results for "niche"

ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells

2020

Lipid Droplets (LDs) are emerging as crucial players in colon cancer development and maintenance. Their expression has been associated with high tumorigenicity in Cancer Stem Cells (CSCs), so that they have been proposed as a new functional marker in Colorectal Cancer Stem Cells (CR-CSCs). They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory molecules. There is growing evidence that a possible connection between metabolic alterations and malignant transformation exists, although the effects of nutrients, primarily glucose, on the CSC behavior are still mostly unexplored. Glucose is an essential fuel for cancer cells, an…

The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical Hypoparathyroidism-Related Hypocalcemia Refractory to Supplem…

2017

The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia. The aim of the study was to evaluate the biochemical mechanisms inducing hypocalcemia in a female patient with usual high consumption of cola drink and persistent hypocalcemia, who failed to respond to high doses of calcium and calcitriol supplementation. At baseline and after pentagastrin injection, gastric and duodenal secretion samples were collected and calcium and total phosphorus concentrations were evaluated. At the same time, blood calcium, total phosphorus, sodium, potassium, chloride, magnesium concentrations and vitamin D were sampled. After intake of cola (1 L) over 180 min, gastric and du…

Polyphenol-rich and alcoholic beverages and metabolic status in adults living in Sicily, Southern Italy

2021

Polyphenol-rich beverage consumption is not univocally accepted as a risk modulator for cardio-metabolic risk factors, despite mechanistic and epidemiological evidence suggesting otherwise. The aim of this study was to assess whether an association between polyphenol-rich beverage consumption and metabolic status could be observed in a Mediterranean cohort with relatively low intake of tea, coffee, red and white wine, beer, and fresh citrus juice. Demographic and dietary characteristics of 2044 adults living in southern Italy were analyzed. Multivariate logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of the association between polyphe…

Dietary restriction: could it be considered as speed bump on tumor progression road?

2016

Dietary restrictions, including fasting (or long-term starvation), calorie restriction (CR), and short-term starvation (STS), are considered a strong rationale that may protect against various diseases, including age-related diseases and cancer. Among dietary approaches, STS, in which food is not consumed during designed fasting periods but is typically not restricted during designated feeding periods, seems to be more suitable, because other dietary regimens involving prolonged fasting periods could worsen the health conditions of cancer patients, being they already naturally prone to weight loss. Until now, the limited amount of available data does not point to a single gene, pathway, or …

Genomic and non-genomic mechanisms of action of thyroid hormones and their catabolite 3,5-diiodo-l-thyronine in Mammals

2020

Since the realization that the cellular homologs of a gene found in the retrovirus that contributes to erythroblastosis in birds (v-erbA), i.e. the proto-oncogene c-erbA encodes the nuclear receptors for thyroid hormones (THs), most of the interest for THs focalized on their ability to control gene transcription. It was found, indeed, that, by regulating gene expression in many tissues, these hormones could mediate critical events both in development and in adult organisms. Among their effects, much attention was given to their ability to increase energy expenditure, and they were early proposed as anti-obesity drugs. However, their clinical use has been strongly challenged by the concomita…

Pain Education in Schools of Nursing: a Survey of the Italian Academic Situation.

2018

Introduction: Proper assessment of pain is imperative for the development of an effective pain management plan and is a core responsibility of nurses and healthcare professionals. This article describes the contents of Italian on-line bachelor's in nursing degree programs, with particular focus on pain management.Method: A descriptive study was made on curricula published and available on-line in Italian Nursing Schools, and the concordance with the standards set by the Consensus Curriculum on Pain for Nursing ofthe International Association for the Study of Pain (IASP, 2015) was analyzed.Results: Of all the bachelor programs published on-line, 42.6% offered programs and courses specificall…

ROLE OF 3,5-DIIODO-L-THYRONINE ON THE PITUITARY-THYROID AXIS

2018

Caracterización y mantenimiento in vitro de células germinales inducidas para la preservación de la fertilidad

2017

INTRODUCCIÓN La infertilidad es una condición clínica que afecta al 15% de las parejas en edad reproductiva; de las cuales un 28% se ven afectadas por diferentes patologías que resultan en la ausencia de gametos, dentro de este porcentaje se incluyen pacientes con fallo ovárico precoz, mujeres postmenopáusicas y pacientes masculinos diagnosticados de azoospermia no-obstructiva o cualquier otra patología que conlleve la ausencia de espermatozoides funcionales o, al menos, espermátidas elongadas que permitan su uso en tratamientos de reproducción asistida. Estas patologías producen infertilidad en el 1% de las mujeres y el 0.63% de los hombres, en la población general; como consecuencia el us…

Funzione e limiti dell’autonomia privata nei contratti transnazionali

2022

Ci si chiede se lo stile con cui vengono redatti i contratti transnazionali possa effettivamente favorire un’interpretazione maggiormente aderente al testo contrattuale. Nella pratica, specialmente in quella internazionale, non pare si possa dubitare che un’accorta applicazione delle tecniche di protezione letterale del contratto possa risultare utile allo scopo.

ADC based measurements: A common basis for the uncertainty estimation

2010

In the last years, many Authors have dealt with the uncertainty evaluation of the measurement performed by using an analog-to-digital converter, proposing different approaches to analyze the uncertainty propagation. However, in these studies, in order to identify the uncertainty sources, different sets of parameters are used, and, often, it is not considered that the various uncertainty sources have different modalities of propagation. Obviously, this implies that the various proposed approaches are not directly comparable. One of the main reasons which has caused this situation is the coexistent of various Standards concerning the characterization of the analog-to-digital converters. There…