Search results for "nobody"

Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels

2020

To target nanomedicines to specific cells, especially of the immune system, nanobodies can be considered as an attractive tool, as they lack the Fc part as compared to traditional antibodies and, thus, prevent unfavorable Fc-receptor mediated mistargeting. For that purpose, we have site-specifically conjugated CD206/MMR-targeting nanobodies to three types of dye-labeled nanogel derivatives: non-degradable nanogels, acid-degradable nanogels (with ketal crosslinks), and single polymer chains (also obtained after nanogel degradation). All of them can be obtained from the same reactive ester precursor block copolymer. After incubation with na&iuml

Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

2017

Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes membrane fission (Schmid and Frolov, 2011; Ferguson and De Camilli, 2012). Dynamin fission reaction is strictly dependent on GTP hydrolysis, but how fission is mediated is still debated (Antonny et al., 2016): GTP energy could be spent in membrane constriction required for fission, or in disassembly of the dynamin polymer to trigger fission. To follow dynamin GTP hydrolysis at endocytic pits, we generated a conformation-specific nanobody called dynab, that binds preferentially to the GTP hydrolytic state of dynamin-1. Dynab allowed us to follow the GTPase activity of dynamin-1 in real-time. We…

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

2018

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymp…

Resilience, security and the politics of processes

2014

The prominence of resilience thinking in contemporary governance and security policies has received increasing critical attention. By engaging in dialogue with some of these recent critiques, predominantly leaning on biopolitics or neoliberal governmentality, this article develops an Arendtian reading of resilience as a temporal regime of processuality. Originating from life sciences such as ecology and complexity thinking, the increasingly malleable resilience discourse privileges the functioning of societal life processes over political action and human artifice. The article argues that this ‘rule of nobody’ is in danger of suffocating the concept of public space, so crucial for politics …

Retóricas del momento: (per)versiones (mis)antropológicas

2018

Durante la organización del XIV Congreso de Antropología celebrado en Valencia en septiembre de 2017, bajo el lema Antropologías en transformación: sentidos, compromisos y utopías, los miembros del comité organizador dudábamos de cuál podría ser el tópico de la conferencia de clausura y qué insigne personalidad de nuestro campo podría ocupar ese lugar privilegiado. Como no teníamos a nadie en cartel ni tampoco osábamos importunar a algún/a colega con tamaña empresa emprendimos la tarea de crear un personaje ad hoc que reuniera el suficiente atractivo en una ocasión tan connotada. En seguida vimos que la idea ofrecía una oportunidad incomparable para reflexionar de forma crítica sobre la aca…

2006

The Strawson´s Basic Argument is the stronger against moral responsibility in Philosophy of action. One should be responsible of his identity to be moral responsible of his actions, but then nobody could be never responsible. In this article I criticize orthodox solutions to Strawson´s sceptical challenge and show how they share with the Argument the same theological notion of monadical agent. A new solution needs a new conception of agent..

Christian Konrad Sprengel’s Theory of the Flower: The Cradle of Floral Ecology

1996

As the plant taxonomist Karl Suessenguth once wrote, there are two kinds of discoveries: Detecting a thing nobody has seen before, or thinking what no one has thought before about something that everybody sees. A discovery of the second kind, and one of great moments in our science, was Sprengel’s theory of the flower. This theory clearly expressed for the first time the notion that flowers are designed for the transmission of pollen by foreign vectors, that is, animals or wind, and they can be understood only from this perspective.

Auf den Spuren öffentlicher Meinung im mittelhochdeutschen Minnesang

2011

The scope of this study is to analyse if and how traces of public opinion, in the sociopsychological sense of social control, may be found in the German medieval love lyrics. With the aid of a hermeneutic text analysis some selected Middle High German minnesongs are exemplarily examined. The analysis shows that awareness of public opinion as social control did exist in the Middle Ages. On the one hand, there are minnesongs that raise the topics ere (honour) and spot (mockery). In these songs public mockery represents a threat of isolation against individuals who do not conform to public opinion. Because mockery may lead to loss of honour and to social isolation, mockery pressures individual…

The Einstein field equation in a multidimensional universe

1988

String theory [4] predicts that the universe has 10 or 26 dimensions. A salient problem is how the Einstein field equation should be written in terms of these revivified Kaluza-Klein cosmologies. The answer is by now well-known, yet nobody seems to have rewritten the seminal computation in [6] where an unnecessarily involved Euler-Lagrange variational method is employed and, curiously enough, no allusion to the Gauss-Bonnet-Chern theorem is made. We provide a more straightforward argument, which has been inspired by Hilbert's original derivation of the Einstein field equation [5].

La autonomía moral en el yusnaturalismo tomasiano

2007

Aquinas seems to hold following theses on moral autonomy. (1) «Nobody imposes his acts the law»: there is no perfect, no radical autonomy (even in Kant). (2) Natural law is defined as participation in the eternal law. That means «theonomy» which for Kluxen is not primordial, but adventitious metaphysical interpretation. (3) We could speak of «cognitive autonomy»: human reason is competent to formulate norms and moral judgements. (4) But the cognitive acts are accompanied by voluntary consent: which is natural and necessary in first principles; becomes worlds consens in the natural law conclusions (see the general opinion of Spanish Scholastics); and becomes correct desire in prudence and, e…