Search results for "nobody"
showing 10 items of 14 documents
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells
2018
CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymp…
Christian Konrad Sprengel’s Theory of the Flower: The Cradle of Floral Ecology
1996
As the plant taxonomist Karl Suessenguth once wrote, there are two kinds of discoveries: Detecting a thing nobody has seen before, or thinking what no one has thought before about something that everybody sees. A discovery of the second kind, and one of great moments in our science, was Sprengel’s theory of the flower. This theory clearly expressed for the first time the notion that flowers are designed for the transmission of pollen by foreign vectors, that is, animals or wind, and they can be understood only from this perspective.
An active inference and epistemic value view of metacognition
2015
Metacognition concerns our monitoring and control of mental operations (knowing what you know). Much thinking about metacognition is liable to fall foul of the classic homunculus problem: Nobody can specify who or what does the "metacognition." We describe how the Active Inference and Epistemic Value (AIEV) model offers an operationalization of epistemic behaviors which can explain two example metacognitive phenomena: Control and monitoring of word learning, and the search for unretrieved information in the feeling of knowing. Curiosity drives a search forward, but it is held in check by considering the utility of what is retrieved from memory.
Experience and Existence Revisited Something Essential on A Philosophical Education in Film Art
2013
Abstract The film, the living imagery, traces out its legend before the eyes of the viewer seated there in the darkened space, and in his consciousness becomes a lived spectacle, an interiorised impress of experience. It takes up its abode in him and he falls in step with its movement, merging with the stream of its narrative. In this there evolves an aesthetic-existential situation – of one, many; of one, a qualitative multiplicity is born, and with it the experienced essence of the unique, the inimitable. On this same, the critic pronounces judgement – as often as not his verdict – on this spectacle which he – and another – has beheld; that individual, original experience is thus now couc…
Resilience, security and the politics of processes
2014
The prominence of resilience thinking in contemporary governance and security policies has received increasing critical attention. By engaging in dialogue with some of these recent critiques, predominantly leaning on biopolitics or neoliberal governmentality, this article develops an Arendtian reading of resilience as a temporal regime of processuality. Originating from life sciences such as ecology and complexity thinking, the increasingly malleable resilience discourse privileges the functioning of societal life processes over political action and human artifice. The article argues that this ‘rule of nobody’ is in danger of suffocating the concept of public space, so crucial for politics …
La autonomía moral en el yusnaturalismo tomasiano
2007
Aquinas seems to hold following theses on moral autonomy. (1) «Nobody imposes his acts the law»: there is no perfect, no radical autonomy (even in Kant). (2) Natural law is defined as participation in the eternal law. That means «theonomy» which for Kluxen is not primordial, but adventitious metaphysical interpretation. (3) We could speak of «cognitive autonomy»: human reason is competent to formulate norms and moral judgements. (4) But the cognitive acts are accompanied by voluntary consent: which is natural and necessary in first principles; becomes worlds consens in the natural law conclusions (see the general opinion of Spanish Scholastics); and becomes correct desire in prudence and, e…
Žako van Dormela filmu “Mr Nobody” un “Le tout nouveau testament” simboli cilvēku uztverē
2018
Bakalaura darba tēma ir “Žako van Dormela filmu “Mr Nobody” un “Le tout nouveau testament” simboli cilvēku uztverē”. Par bakalaura darba pētījuma problēmu tiek uzskatīta simbolu uztveres daudzveidība. Par bakalaura darba problēmjautājumu tika izvirzīts jautājums, kā režisora Žako van Dormela abu filmu skatītāji uztver simbolus un zīmes, kas ir pamanāmas filmās. Bakalaura darba mērķi ir noskaidrot, kādi simboli ir pamanāmi filmās, un kā tie izpaužas, kādus simbolus pamana abu filmu skatītāji, un kāda ir simbolu nozīme filmās.Darbā teorētisko bāzi veidos sekojošas teorijas – kino teorija, vizuālā komunikācija, filmu mērķauditorija, simbolu komunikācija, semiotika un semiotika kino. Darba meto…
Women in Neurosurgery: From a Matter of Fortuitous Occasions Toward a Conscious Choice.
2021
Background Medicine has made progress toward gender equality and has achieved almost equal distribution between men and women among graduates. However, more still needs to be done because most surgical subspecialties are still lacking adequate female representation and this persisting gender gap is particularly evident in both practical neurosurgery and the academic world. Gradual advancements have enabled a few women to pursue a successful career in neurologic surgery, pairing clinical practice with mentoring and involvement in academic research. These efforts show that more needs to be done to bridge the historic and current gap, which has recently aroused increasing interest among the ne…
Retóricas del momento: (per)versiones (mis)antropológicas
2018
Durante la organización del XIV Congreso de Antropología celebrado en Valencia en septiembre de 2017, bajo el lema Antropologías en transformación: sentidos, compromisos y utopías, los miembros del comité organizador dudábamos de cuál podría ser el tópico de la conferencia de clausura y qué insigne personalidad de nuestro campo podría ocupar ese lugar privilegiado. Como no teníamos a nadie en cartel ni tampoco osábamos importunar a algún/a colega con tamaña empresa emprendimos la tarea de crear un personaje ad hoc que reuniera el suficiente atractivo en una ocasión tan connotada. En seguida vimos que la idea ofrecía una oportunidad incomparable para reflexionar de forma crítica sobre la aca…
The Einstein field equation in a multidimensional universe
1988
String theory [4] predicts that the universe has 10 or 26 dimensions. A salient problem is how the Einstein field equation should be written in terms of these revivified Kaluza-Klein cosmologies. The answer is by now well-known, yet nobody seems to have rewritten the seminal computation in [6] where an unnecessarily involved Euler-Lagrange variational method is employed and, curiously enough, no allusion to the Gauss-Bonnet-Chern theorem is made. We provide a more straightforward argument, which has been inspired by Hilbert's original derivation of the Einstein field equation [5].