Search results for "nomo"

Direction and strength of selection by predators for the color of the aposematic wood tiger moth

2011

Conventionally, predation is assumed to select for conspicuousness and uniformity of warning signals in aposematic (i.e., chemically defended and warning signaling) prey because this enhances predators' initial and learned avoidance. On the other hand, it has been suggested that both variation in the background where the signal is displayed as well as variation in predators' probability to attack defended prey may favor intermediate signals or relax selection for signal monomorphism. We studied the direction and strength of selection for the hind wing color (orange vs. red) of female Parasemia plantaginis moths. Birds found the moths aversive and avoided them by sight both in laboratory and…

Students' school performance, task-focus, and situation-specific motivation

2015

Going beyond studies of individual differences in and profiles of students' motivation, we investigated situation-specific (intra-personal) experiences of autonomous (enjoyment, interest, and task choice) and controlled (having to do, and the teacher wanting them to do a task) motivation across learning situations during one week, and how these were related to student characteristics (teacher rated academic performance and task-focus). Three-hundred and fourteen primary school students (Years 5 and 6) completed electronic questionnaires on Personal Digital Assistants, on an average of 11.2 learning episodes during a week. Multilevel Structural Equation Models provided support for a model ba…

Regulatory T Cells and IL-10 Independently Counterregulate Cytotoxic T Lymphocyte Responses Induced by Transcutaneous Immunization

2011

Background: The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role of regulatory T cells (Treg) and the suppressive cytokine IL-10 in restricting TCI-induced cytotoxic T lymphocyte (CTL) responses. Methodology/Principal Findings: TCI was performed with an ointment containing the TLR7 agonist imiquimod and a CTL epitope was applied to the depilated back skin of C57BL/6 mice. Using specific antibodies and FoxP3-diphteria toxin receptor transgenic (DEREG) mice, we interrogated inhibiting factors after…

A Distributed Framework for Scalable Large-Scale Crowd Simulation

2007

Emerging applications in the area of Emergency Response and Disaster Management are increasingly demanding interactive capabilities to allow for the quick understanding of a critical situation, in particular in urban environments. A key component of these interactive simulations is how to recreate the behavior of a crowd in real- time while supporting individual behaviors. Crowds can often be unpredictable and present mixed behaviors such as panic or aggression, that can very rapidly change based on unexpected new elements introduced into the environment. We present preliminary research specifically oriented towards the simulation of large crowds for emergency response and rescue planning s…

Infinitely many periodic solutions for a second-order nonautonomous system

2003

The existence of infinitely many solutions for a second-order nonautonoumous system was investigated. Some multiplicity results for problem (P) under very different assumptions on the potential G were established. It was shown that infinitely many solutions follow from a variational principle by B. Ricceri.

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems.

2015

Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained throughout lifespan. The mechanisms through which these embryonic-derived cells contribute to microglia homoeostasis at steady state and upon inflammation are still not entirely clear. Here we review recent studies that provided insight into the contribution of embryonically-derived microglia and of adult 'microglia-like' cells derived from monocytes during inflammation. We ex…

Idiographic and nomothetic approaches to heterogeneity are complementary: Response to comments on “Evaluating the influences of temperature, primary …

2020

Bourn-normal monomorphisms in regular Mal’tsev categories

2017

Normal monomorphisms in the sense of Bourn describe the equivalence classes of an internal equivalence relation. Although the definition is given in the fairly general setting of a category with finite limits, later investigations on this subject often focus on protomodular settings, where normality becomes a property. This paper clarifies the connections between internal equivalence relations and Bourn-normal monomorphisms in regular Mal’tesv categories with pushouts of split monomorphisms along arbitrary morphisms, whereas a full description is achieved for quasi-pointed regular Mal’tsev categories with pushouts of split monomorphisms along arbitrary morphisms.

Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of …

2011

Purpose The purpose of this study was to develop accurate models and nomograms to predict local recurrence, distant metastases, and survival for patients with locally advanced rectal cancer treated with long-course chemoradiotherapy (CRT) followed by surgery and to allow for a selection of patients who may benefit most from postoperative adjuvant chemotherapy and close follow-up. Patients and Methods All data (N = 2,795) from five major European clinical trials for rectal cancer were pooled and used to perform an extensive survival analysis and to develop multivariate nomograms based on Cox regression. Data from one trial was used as an external validation set. The variables used in the ana…

Prediction of Non-sentinel Node Status in Patients with Melanoma and Positive Sentinel Node Biopsy: An Italian Melanoma Intergroup (IMI) Study

2018

Background and Purpose: Approximately 20% of melanoma patients harbor metastases in non-sentinel nodes (NSNs) after a positive sentinel node biopsy (SNB), and recent evidence questions the therapeutic benefit of completion lymph node dissection (CLND). We built a nomogram for prediction of NSN status in melanoma patients with positive SNB. Methods: Data on anthropometric and clinicopathological features of patients with cutaneous melanoma who underwent CLND after a positive SNB were collected from nine Italian centers. Multivariate logistic regression was utilized to identify predictors of NSN status in a training set, while model efficiency was validated in a validation set. Results: Data …