Search results for "non-Standard"

showing 3 items of 33 documents

Smoothed score confidence interval for the breakpoint in segmented regression

2012

For the breakpoint parameter in segmented regression we consider confidence intervals based on the score statistic. Due to unsmoothness of the score, we propose to build the confidence intervals using its smoothed version under proper shape restrictions. Some simulations are presented to assess the finite sample performance of the proposed approach.

non-standard inferenceshape restrictionbreak-pointscoresegmented regressionSettore SECS-S/01 - Statistica
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Imidazole-amino acids. Conformational switch under tautomer and pH change.

2022

AbstractReplacement of the main chain peptide bond by imidazole ring seems to be a promising tool for the peptide-based drug design, due to the specific prototropic tautomeric as well as amphoteric properties. In this study, we present that both tautomer and pH change can cause a conformational switch of the studied residues of alanine (1–4) and dehydroalanine (5–8) with the C-terminal peptide group replaced by imidazole. The DFT methods are applied and an environment of increasing polarity is simulated. The conformational maps (Ramachandram diagrams) are presented and the stability of possible conformations is discussed. The neutral forms, tautomers τ (1) and π (2), adapt the conformations…

Density Functional Theory (DFT)Conformational analysisOrganic ChemistryClinical BiochemistryTautomersNon-standard amino acidsRamachandran mapBiochemistryImidazoleAmino acids
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Saggezza dei patterns e nuove strategie cooperative

2013

The paper aims to analyze the concept of downward causation and the role that it plays in the theoretical frameworks of biology and cognitive science.

Emergence Reduction Mereology non-standard Downward Causation ComplexitySettore M-FIL/05 - Filosofia E Teoria Dei Linguaggi
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