Search results for "none"
showing 10 items of 1921 documents
Climate signatures on decadal to interdecadal time scales as obtained from mollusk shells (Arctica islandica) from Iceland
2013
Abstract Pronounced decadal climate oscillations are detected in a multi-centennial record based on shell growth rates of the marine bivalve mollusk, Arctica islandica, from Iceland. The corresponding analysis of patterns in sea level pressure and temperature exhibit large-scale teleconnections with North Atlantic climate quantities. We find that the record projects onto blocking situations in the northern North Atlantic. The associated circulation shows a low-pressure signature over Greenland and the Labrador Sea and a high-pressure system over Western Europe associated with northeasterly flow towards Iceland and weakening in the westerly zonal flow over Europe. It can be speculated that s…
Sull’avvio del canone negli studi di storia dell’arte contemporanea nell’era della globalizzazione digitale. Spunti da uno scritto di Cesare Segre
2016
Il saggio propone un ragionamento sull’interazione, sempre più diffusa nella pratica artistica attuale, tra l’autore e il fruitore nella realizzazione dell’opera d’arte. Interazione, coinvolgimento da parte di un pubblico più o meno consapevole, che, certamente, può ritenersi per le arti visive ormai una pratica acquisita ma che, tuttavia, può aprire, se non nuove prospettive, nuovi interrogativi. Secondo l’autrice, infatti, lo storico dell’arte, intervenendo sulla contemporaneità, non può ignorare, nell’epoca dell’intermedialità, nei tempi dell’abbattimento delle frontiere tra i vari generi artistici, nella realtà di una comunità culturale che deve confrontarsi, inevitabilmente, con il web…
Danone, la gouvernance d’une multinationale
2018
National audience; Le groupe Danone s’est hissé parmi les leaders mondiaux de l’industrie agroalimentaire : il est le numéro 1 mondial des produits laitiers frais, le numéro 2 mondial des eaux embouteillées et de la nutrition infantile, et le numéro 3 mondial de la nutrition médicale. En 2016, l’entreprise a réalisé un chiffre d’affaires de 21,94 milliards d’euros et un résultat net de 1,83 milliard d’euros. Elle emploie près de 100 000 salariés. Le présent cas vise à traiter un certain nombre de questions. Comment devient-on un leader mondial de l’industrie agroalimentaire : par l’adaptation permanente aux évolutions de l’environnement, par leur anticipation ou par les changements de strat…
Using exomarkers to assess mitochondrial reactive species in vivo
2014
Background:\ud The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods can be applied to in vitro systems, measuring the levels and relative changes in reactive species in vivo is challenging.\ud \ud Scope of review:\ud One approach towards achieving this goal is the use of exomarkers. In this, exogenous probe compounds are administered to the intact organism and are then transformed by the reactive molecules in vivo to produce a diagnostic exomarker. The exomarker and the precursor probe can be analysed ex vivo to infer the identity and a…
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups☆
2013
Background Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality. Objectives To assess if prolonging in utero-like oxygenation during the fetal-to-neonatal transition limits oxidative stress in the lung and brain, improving postnatal adaptation of mice pups. Material and methods Inspiratory oxygen fraction (FiO2) in pregnant mice was reduced from 21% (room air) to 14% (hypoxia) 8–12 h prior to delivery and reset to 21% 6–8 h after birth. The control group was kept at 21% during the procedure. Reduced (GSH) and oxidized (GSSG) glutathione and its precursors [γ-glut…
Scalable (Enantioselective) Syntheses of Novel 3-Methylated Analogs of Pazinaclone, (S)-PD172938 and Related Biologically Relevant Isoindolinones
2022
Herein, we report the application of an efficient and practical K2CO3 promoted cascade reaction of 2-acetylbenzonitrile in the synthesis of novel 3-methylated analogs of Pazinaclone and PD172938, belonging to isoindolinones heterocyclic class bearing a tetrasubstituted stereocenter. Organocatalytic asymmetric synthesis of the key intermediate and its transformation into highly enantioenriched 3-methylated analog of (S)-PD172938 was also developed. These achievements can be of particular interest also for medicinal chemistry, since the methyl group is a very useful structural modification in the rational design of new and more effective bioactive compounds.
Human neonatal responses to androstenone
2010
Poster P327 session VII: Olfactory Psychophysics & Clinical Studies; Central Olfaction; Aims. Human newborns show equal attraction to the odors of amniotic. fluid (AF) and mothers’ colostrum [1]. As 5-a-androst-16-en-3-. one (An) has been found in both fluids [2, 3], we studied it as a. potential vector of this perinatal odor continuity and of neonatal. attraction to the smell of breast and milk [4]. Methods. Two studies. were run. 1) We recorded the behavior of 16 newborns (3 days) and. 26 adults exposed to a saturating water solution of An and to 3. reference odorants [butyric acid, B; vanilla, V; water, W]. 2) We videotaped. 26 newborns (3 days) being administered 7 stimuli: 4 dilution. …
Crystal structure and Hirshfeld surface analysis of (2E)-3-(3-bromo-4-fluorophenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
2018
The title compound is constructed from two aromatic rings (3-bromo-4-fluorophenyl and 3,4-dimethoxyphenyl), which are linked by a C=C—C(=O)—C enone bridge and form a dihedral angle of 17.91 (17)°. In the crystal, molecules are linked by C—H⋯O hydrogen bonds enclosing rings of (14) graph-set motif to form layers parallel to (10).
Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells E…
2022
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber’s hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone’s cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions …
Advances towards highly active and stereoselective simple and cheap proline-based organocatalysts
2010
Ten 4-acyloxy-L-prolines were screened as catalysts at loadings of 2–0.1 mol-% for the direct asymmetric aldol reaction in water by using variable amounts of water. Among them, a new catalyst, the L-proline carrying a trans-4-(2,2-diphenylacetoxy) group, and a catalyst previously synthesized by us, the L-proline carrying a trans-4-(4-phenylbutanoyloxy) group, were found to be excellent catalysts for the aldol reaction between cyclohexanone or cyclopentanone and substituted benzaldehydes when employed in only 1 and 0.5 mol-%,respectively, at room temperature without additives. For such catalysts, high turnover numbers were obtained, which are among the highest values obtained for enamine org…