Search results for "noninvasive"

showing 10 items of 109 documents

Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

2021

International audience; Background & aims: Based on platelets and liver stiffness measurements, the Baveno VI criteria (B6C), the expanded B6C (EB6C), and the ANTICIPATE score can be used to rule out varices needing treatment (VNT) in patients with compensated chronic liver disease. We aimed to improve these tests by including data on the ratio of platelets to liver stiffness.Methods: In a retrospective analysis of data from 10 study populations, collected from 2004 through 2018, we randomly assigned data from 2368 patients with chronic liver disease of different etiologies to a derivation population (n = 1579; 15.1% with VNT, 50.2% with viral hepatitis, 28.9% with nonalcoholic fatty liver …

Blood PlateletsLiver CirrhosisNoninvasive Diagnosismedicine.medical_specialtyCirrhosis[SDV]Life Sciences [q-bio]PopulationEsophageal and Gastric VaricesChronic liver diseaseSeverity of Illness IndexGastroenterologyEnd Stage Liver Disease03 medical and health sciencesLiver disease0302 clinical medicineModel for End-Stage Liver DiseaseEsophageal varicesInternal medicineNonalcoholic fatty liver diseasemedicineHumanseducationBaveno VI CriteriaRetrospective Studieseducation.field_of_studyHepatologybusiness.industryGastroenterologyRetrospective cohort studyPortal Hypertensionmedicine.disease3. Good healthMELDCirrhosis030220 oncology & carcinogenesisElasticity Imaging Techniques030211 gastroenterology & hepatologybusinessBaveno VI Criteria Blood Platelets Cirrhosis Elasticity Imaging Techniques End Stage Liver Disease Esophageal and Gastric Varices Humans Liver Cirrhosis MELD Noninvasive Diagnosis Portal Hypertension Retrospective Studies Severity of Illness Index
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Sedation and analgesia during noninvasive ventilation (NIV)

2017

The use of noninvasive ventilation (NIV) has increased significantly in patients with acute respiratory failure (ARF) in order to prevent tracheal intubation and its complications. Unfortunately, NIV failure represents a frequent event, with rates that in some cases reach 40%. Mask intolerance, agitation, and delirium may lead to NIV failure, thus requiring endotracheal intubation. NIV failure rates are higher in patients without chronic obstructive pulmonary disease (COPD), and, when used in acute hypoxemic failure, its failure is associated with an increased mortality rate. The practice of sedation during NIV could be a valuable option for patients at risk of intubation. Sedation may decr…

COPDbusiness.industrySedationmedicine.medical_treatmentMortality rateventilationTracheal intubation030208 emergency & critical care medicineEndotracheal intubationmedicine.disease03 medical and health sciences0302 clinical medicine030228 respiratory systemsedationAnesthesiamedicineDeliriumNoninvasive ventilationmedicine.symptomDexmedetomidinebusinessmedicine.drug
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Hunting for the high-affinity state of G-protein-coupled receptors with agonist tracers: Theoretical and practical considerations for positron emissi…

2019

Abstract The concept of the high‐affinity state postulates that a certain subset of G‐protein‐coupled receptors is primarily responsible for receptor signaling in the living brain. Assessing the abundance of this subset is thus potentially highly relevant for studies concerning the responses of neurotransmission to pharmacological or physiological stimuli and the dysregulation of neurotransmission in neurological or psychiatric disorders. The high‐affinity state is preferentially recognized by agonists in vitro. For this reason, agonist tracers have been developed as tools for the noninvasive imaging of the high‐affinity state with positron emission tomography (PET). This review provides an…

Central Nervous SystemBETA-ADRENERGIC-RECEPTORpositron emission tomographyagonist high-affinity stateD-2/3 AGONISTG-protein-coupled receptorsReview ArticleReceptors G-Protein-Coupledchemistry.chemical_compound0302 clinical medicineDrug DiscoveryReceptorNeurotransmitterReview Articles0303 health sciencesmedicine.diagnostic_testNONHUMAN PRIMATE BRAINEndocytosisTEST-RETEST REPRODUCIBILITYPositron emission tomographyG‐protein‐coupled receptors030220 oncology & carcinogenesisENDOGENOUS OPIOID RELEASEMolecular MedicineIN-VIVO BINDINGSignal TransductionAgonistNoninvasive imagingexperimental designmedicine.drug_classNeurotransmissionRAT-BRAINneurotransmittersagonist high‐affinity state03 medical and health sciencesIn vivomedicineAnimalsHumanshuman brain030304 developmental biologyG protein-coupled receptorPharmacologyDOPAMINE D2(HIGH) RECEPTORS5-HT1A RECEPTORSchemistryPositron-Emission TomographyPET RADIOLIGANDRadiopharmaceuticalsNeuroscienceMedicinal research reviews
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High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol f…

2019

Background Noninvasive ventilation (NIV) is indicated to treat respiratory acidosis due to exacerbation of chronic obstructive pulmonary disease (COPD). Recent nonrandomized studies also demonstrated some physiological effects of high-flow nasal therapy (HFNT) in COPD patients. We designed a prospective, unblinded, multicenter, randomized controlled trial to assess the noninferiority of HFNT compared to NIV with respect to the reduction of arterial partial pressure of carbon dioxide (PaCO2) in patients with hypercapnic acute respiratory failure with mild-to-moderate respiratory acidosis. Methods We will enroll adult patients with acute hypercapnic respiratory failure, as defined by arterial…

Chronic ObstructiveTime FactorsExacerbationRespiratory ratemedicine.medical_treatmentMedicine (miscellaneous)Equivalence Trials as TopicAcute respiratory failurelaw.inventionPulmonary DiseaseHypercapnia03 medical and health sciencesPulmonary Disease Chronic ObstructiveStudy Protocol0302 clinical medicineAcute respiratory failure; Carbon dioxide; Chronic obstructive pulmonary disease; Emergency department; High-flow oxygen therapy through nasal cannula; Intensive care unit; Noninvasive ventilation; Acute Disease; Equivalence Trials as Topic; Humans; Hypercapnia; Italy; Lung; Multicenter Studies as Topic; Oxygen Inhalation Therapy; Prospective Studies; Pulmonary Disease Chronic Obstructive; Respiratory Insufficiency; Time Factors; Treatment Outcome; Noninvasive VentilationRandomized controlled triallawHigh-flow oxygen therapy through nasal cannulamedicineHumansMulticenter Studies as TopicPharmacology (medical)Intensive care unit030212 general & internal medicineProspective StudiesLungTidal volumeMechanical ventilationCOPDlcsh:R5-920business.industryEmergency departmentChronic obstructive pulmonary diseaseOxygen Inhalation Therapymedicine.diseaseIntensive care unitRespiratory acidosisTreatment OutcomeItalyCarbon dioxideAnesthesiaAcute DiseasebusinessRespiratory Insufficiencylcsh:Medicine (General)Acute respiratory failure; Carbon dioxide; Chronic obstructive pulmonary disease; Emergency department; High-flow oxygen therapy through nasal cannula; Intensive care unit; Noninvasive ventilationNoninvasive ventilation030217 neurology & neurosurgeryTrials
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Pulmonologists, Mechanical Ventilation and Complementary Techniques

2014

Complementary TherapiesPatient Care TeamMechanical ventilationmedicine.medical_specialtyNoninvasive Ventilationbusiness.industryInterprofessional Relationsmedicine.medical_treatmentGeneral MedicineCoughSocioeconomic FactorsPulmonary MedicineWorkforceHumansMedicinebusinessIntensive care medicinePulmonologistsArchivos de Bronconeumología (English Edition)
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Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

2020

Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…

Coronavirus COVID-19 Pneumonia SARS-CoV-2 TocilizumabGCA Giant cell arteritispJIA Pediatric juvenile idiopathic arthritislaw.inventionchemistry.chemical_compound0302 clinical medicineRandomized controlled triallawMedicine030212 general & internal medicineClinical efficacyCPAP Continuous positive airway pressureCOVID-19 Coronavirus disease 2019IDSA Infectious Diseases Society of AmericaRA Rheumatoid arthritisTocilizumabIMV Invasive mechanical ventilationsJIA Juvenile idiopathic arthritisAIFA Agenzia Italiana del FarmacoPulmonary and Respiratory Medicinemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MEDLINEAntibodies Monoclonal HumanizedNIH U.S. National Institutes of HealthArticleWHO World Health OrganizationSIMIT Italian Society of Infectious and Tropical disease03 medical and health sciencesTocilizumabARDS Acute respiratory distress syndromeAnimalsHumansIn patientIntensive care medicineTocilizumab ; COVID-19 ; Pneumonia ; SARS-CoV-2 ; Coronaviruslcsh:RC705-779business.industryCRS CAR-T cell-induced cytokine release syndromeInterleukin-6SARS-CoV-2NIV Noninvasive mechanical ventilationTNF Tumor necrosis factorCOVID-19Pneumonialcsh:Diseases of the respiratory systemCOVID-19 Drug TreatmentClinical trialCoronavirus030228 respiratory systemchemistrybusinessICTRP International Clinical Trials Registry PlatformPulmonology
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Respiratory support techniques to avoid desaturation in critically ill patients requiring endotracheal intubation: A systematic review and meta-analy…

2017

Abstract Purpose To evaluate which respiratory support method for critically ill patients undergoing endotracheal intubation (ETI) is associated with less desaturation. Methods We searched PubMed, Cochrane Library, Scopus and CINAHL databases. We included randomized (RCT) and non-randomized (non-RCT) studies investigating any method of respiratory support before/during ETI compared to a reference control. Results Apneic oxygenation (ApOx) was the most commonly investigated respiratory support technique for critically ill patients undergoing intubation (4 RCTs, 358 patients). Three of these studies investigated high-flow nasal cannula (HFNC) for ApOx while standard nasal cannula was used in …

Critical CareDatabases Factualmedicine.medical_treatmentAirway management; Apneic oxygenation; Endotracheal intubation; Noninvasive ventilation; Oxygen inhalation therapy; PreoxygenationCritical IllnessSettore MED/41 - AnestesiologiaEndotracheal intubationAirway managementCochrane LibraryCritical Care and Intensive Care Medicinemedicine.disease_causelaw.invention03 medical and health sciences0302 clinical medicineApneic oxygenationRandomized controlled triallawPreoxygenationmedicineIntubation IntratrachealIntubationCannulaHumansMED/41 - ANESTESIOLOGIAHypoxiabusiness.industryOxygen inhalation therapy030208 emergency & critical care medicineEndotracheal intubationRespiration ArtificialIntubation procedure030228 respiratory systemMeta-analysisAnesthesiaCritical IllneAirway managementbusinessRespiratory InsufficiencyNasal cannulaNoninvasive ventilationHuman
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Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas

2019

<b><i>Background:</i></b> Noninvasive mechanical ventilation (NIV) is an effective treatment in patients with neuromuscular diseases (NMD) to improve symptoms, quality of life, and survival. <b><i>Summary:</i></b> NIV should be used early in the course of respiratory muscle involvement in NMD patients and its requirements may increase over time. Therefore, training on technical equipment at home and advice on problem solving are warranted. Remote monitoring of ventilator parameters using built-in ventilator software is recommended. Telemedicine may be helpful in reducing hospital admissions. Anticipatory planning and palliative care should be …

Duchenne muscular dystrophyPulmonary and Respiratory MedicineRespiratory Therapymedicine.medical_specialtyTelemedicineTime FactorsPalliative caremedicine.medical_treatmentNeuromuscular disorderHome care03 medical and health sciencesTracheostomy0302 clinical medicineQuality of life (healthcare)Health caremedicineRespiratory muscleHumansIn patient030212 general & internal medicineIntensive care medicineAmyotrophic lateral sclerosiAmyotrophic lateral sclerosis; Duchenne muscular dystrophy; Home care; Neuromuscular disorders; Noninvasive ventilation; TracheostomyMechanical ventilationbusiness.industryNeuromuscular DiseasesAmyotrophic lateral sclerosisRespiration Artificial030228 respiratory systemQuality of LifeRespiratory InsufficiencybusinessNoninvasive ventilationNeuromuscular disordersFollow-Up StudiesLong term ventilationRespiration
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Integrated three-dimensional models for noninvasive monitoring and valorization of the Morgantina silver treasure (Sicily)

2016

The Morgantina silver treasure belonging to the Archaeological Museum of Aidone (Sicily) was involved in a three-dimensional (3-D) survey and diagnostics campaign for monitoring the collection over time in anticipation of their temporary transfer to the Metropolitan Museum of Art in New York for a period of 4 years. Using a multidisciplinary approach, a scientific and methodological protocol based on noninvasive techniques to achieve a complete and integrated knowledge of the precious items and their conservation state, as well as to increase their valorization, has been developed. All acquired data, i.e., 3-D models, ultraviolet fluorescence, x-ray images, and chemical information, will be…

Engineering3d scanningnoninvasive diagnostic01 natural sciencessemantic annotationthree-dimensional scanning; reverse modeling; noninvasive diagnostics; semantic annotations; web-oriented platformweb-oriented platform0601 history and archaeologyElectrical and Electronic EngineeringThree dimensional scanningUltraviolet radiationSettore L-ART/04 - Museologia E Critica Artistica E Del Restauroreverse modeling060102 archaeologySettore INF/01 - Informaticabusiness.industry010401 analytical chemistry3d image processing06 humanities and the artsData scienceAtomic and Molecular Physics and Optics0104 chemical sciencesComputer Science ApplicationsSettore ICAR/17 - DisegnoTreasurethree-dimensional scanningbusinessTelecommunicationsUltraviolet fluorescenceReverse modelingSettore MED/36 - Diagnostica Per Immagini E RadioterapiaThree dimensional model
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Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes

2023

Background: We evaluated the diagnostic accuracy of simple non-invasive tests(NITs) in NAFLD patients with type 2 diabetes(T2D). Methods: This was an individual patient data meta-analysis of 1780 patients with biopsy-proven NAFLD and T2D. The index tests of interest were FIB-4, NAFLD Fibrosis Score(NFS), APRI, liver stiffness measurement(LSM) by vibration-controlled transient elastography(VCTE) and AGILE 3+. The target conditions were advanced fibrosis, nonalcoholic steatohepatitis(NASH) and fibrotic NASH(NASH plus F2-F4 fibrosis). The diagnostic performance of NITs individually or in sequential combination was assessed by area under receiver operating characteristic curve(AUROC) and by dec…

Hepatologynafld diabetes noninvasive fibrosis
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