Search results for "nootropi"
showing 3 items of 23 documents
Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice.
2001
The present study tests the effects of glucose and choline, the biosynthetic precursors of acetylcholine, on passive avoidance behaviour and hippocampal acetylcholine release measured by microdialysis in awake mice. Glucose (10 and 30mg/kg) or choline chloride (6-60mg/kg), given by i.p. injection immediately after training, dose-dependently enhanced retention in an inhibitory avoidance task. Combinations of low doses of glucose (10mg/kg) and choline chloride (20mg/kg) which alone were submaximally effective significantly increased retention latencies in a synergistic manner, an effect which was sensitive to atropine (0.5mg/kg). This beneficial effect vanished when higher doses of glucose or…
Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer’s disease
2001
Cholinesterase inhibitors are the only approved drug treatment for patients with mild to moderately severe Alzheimer's disease. Interestingly, the clinical potency of these drugs does not correlate well with their activity as cholinesterase inhibitors, nor is their action as short lived as would be expected from purely symptomatic treatment. A few cholinesterase inhibitors, including galantamine, produce beneficial effects even after drug treatment has been terminated. These effects assume modes of action other than mere esterase inhibition and are capable of inducing systemic changes. We have recently discovered a mechanism that could account, at least in part, for the above-mentioned unex…
Stress and use of psychostimulants and nootropics
2022
Mūsdienās daudzi cilvēki saskaras ar stresu un trauksmi sakarā ar darbu, mācīšanas vai citiem iemesliem.Bakalaura darba mērķis bija noskaidrot iedzivotāju stressa un trauksmes iemeslus, kā arī noskaidrot vispieprasītākos recepšu nomierinošus līdzekļus. Tika izmantota kvalitatīva pētniecības metode – anketēšana. Tika noskaidrots, ka galvenie stresa faktori respondentiem ir darbs, mācības un Covid-19 pandēmijas apstākļi.