Search results for "notch"

showing 3 items of 93 documents

Duchenne Muscular Dystrophy (DMD): Should it be Considered a Systemic Disease?

2016

Duchenne muscular dystrophy (DMD) is an X-linked muscle disease characterized by progressive skeletal muscle loss and development of respiratory failure due to involvement of respiratory muscles. Similar to human DMD, the mdx mouse model lacks dystrophin but is characterized by relatively mild muscle injury, allowing testing the effects of mild endurance exercise training on dystrophic skeletal muscle. We were interested to study the effects of exercise training on airway cells in trained mdx mice by applying the same protocol previously tested in Swiss mice. We found that mdx mice showed little airway inflammation associated with training, but developed increasing apoptosis of airway cells…

musculoskeletal diseasescongenital hereditary and neonatal diseases and abnormalitiesmdx mousePathologymedicine.medical_specialtyAirway epitheliumDuchenne muscular dystrophyNotch pathwaySkeletal muscleSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologymedicine.diseaseChaperonin Hsp60Settore BIO/09 - FisiologiaDystrophinmedicine.anatomical_structureRespiratory failureEndurance trainingmedicinebiology.proteinRespiratory epitheliumRespiratory systemDystrophinGoblet cellSingle Cell Biology
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Morphomechanics of the humero-ulnar joint: I. Joint space width and contact areas as a function of load and flexion angle

1995

BACKGROUND Previous studies have shown that the trochlear notch is deeper than necessary for an exact fit with the humerus. However, humero-ulnar joint space width and contact areas have so far not been quantified for variations in the load and angle of flexion. METHODS Six fresh cadaveric specimens were investigated at 30 degrees, 60 degrees, 90 degrees, and 120 degrees of flexion and at loads of 25 and 500 N, simulating resisted elbow extension. The joint space width and contact were determined, using polyether casting material. RESULTS At 25 N all joints made contact in the ventral and dorsal aspects of the articular surfaces, whereas in the depth of the trochlear notch the joint space w…

musculoskeletal diseasesmedicine.medical_specialtyElbowGeometrymedicine.disease_causeAgricultural and Biological Sciences (miscellaneous)Weight-bearingSurgerymedicine.anatomical_structureTrochlear notchPosition (vector)medicineHumerusAnatomyCadaveric spasmRange of motionJoint (geology)MathematicsThe Anatomical Record
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Aston Medical Duocentric® Reversed Prosthesis: Proposition of New Glenoid Component Design to Prevent Scapular Neck Notching

2015

Medialization of the center of rotation in reverse shoulder arthroplasty (RSA) results in greater excursion of the proximal humerus especially in adduction leading to a mechanical conflict against the neck of the scapula, thus creating a specific complication: scapular notching, in up to 90 % of RSA. We describe our third generation of RSA in Dijon, the Duocentric prosthesis. This prosthesis provides a new proposition to prevent the notching problem with an inferior overhang integrated to the glenoid baseplate. Such an inferior extension prevents the malpositioning of the hemisphere and resurfaces the “critical zone” preventing notching.Phenomenon while a smaller neck-shaft angle on the hum…

musculoskeletal diseasesmedicine.medical_specialtybusiness.industrymedicine.medical_treatmentScapular notchingmusculoskeletal systemArthroplastyProsthesisSurgerymedicine.anatomical_structureNotchingScapulaEpiphysismedicineHumerusbusinessInstant centre of rotation
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