Search results for "novel"
showing 10 items of 684 documents
An siRNA-based screen in C2C12 myoblasts identifies novel genes involved in myogenic differentiation
2017
International audience; AbstractMyogenesis is a highly regulated multi-step process involving myoblast proliferation and differentiation. Although studies over the last decades have identified several factors governing these distinct major phases, many of them are not yet known. In order to identify novel genes, we took advantage of the C2C12 myoblastic line to establish a functional siRNA screen combined with quantitative-imaging analysis of a large amount of differentiated myoblasts. We knocked down 100 preselected mouse genes without a previously characterized role in muscle. Using image analysis, we tracked gene-silencing phenotypes by quantitative assessment of cellular density, myotub…
Microcephaly/Trigonocephaly, Intellectual Disability, Autism Spectrum Disorder, and Atypical Dysmorphic Features in a Boy with Xp22.31 Duplication
2019
The Xp22.31 segment of the short arm of the human X chromosome is a region of high instability with frequent rearrangement. The duplication of this region has been found in healthy people as well as in individuals with varying degrees of neurological impairment. The incidence has been reported in a range of 0.4-0.44% of the patients with neurological impairment. Moreover, there is evidence that Xp22.31 duplication may cause a common phenotype including developmental delay, intellectual disability, feeding difficulty, autistic spectrum disorders, hypotonia, seizures, and talipes. We report on a patient with microcephaly and trigonocephaly, moderate intellectual disability, speech and languag…
Diagnostic Criteria for Parkinson's Disease: From James Parkinson to the Concept of Prodromal Disease.
2018
The diagnosis of Parkinson’s disease (PD) is based on clinical features and differently to the common opinion that detecting this condition is easy, seminal clinico-pathological studies have shown that up one-fourth of patients diagnosed as PD during life has an alternative diagnosis at post-mortem. The misdiagnosis is even higher when only the initial diagnosis is considered, since the diagnostic accuracy improves by time, during follow-up visits. Given that the confirmation of the diagnosis of PD can be only obtained through neuropathology, to improve and facilitate the diagnostic-therapeutic workup in PD, a number of criteria and guidelines have been introduced in the last three decades.…
Wow! They really like celeriac! Kindergarten teachers' experiences of an intervention to increase 1-year-olds' acceptance of vegetables
2021
Abstract Exposure to varied foods in early life is important for short- and long-term health and development. Strategically introducing toddlers to new vegetables is not a common practice in Norwegian kindergartens. Therefore, we developed, conducted, and evaluated a web-based cluster randomised kindergarten intervention, Pre-schoolers’ Food Courage 2.0. The purpose of the current qualitative study was to explore kindergarten teachers' experience of implementing this intervention and what they thought facilitated the positive impact of the intervention reported in the quantitative evaluation. Ten individual telephonic interviews with kindergarten teachers who took part in the intervention s…
Changes in the Semantic Construction of Compassion after the Cognitively-Based Compassion Training (CBCT®) in Women Breast Cancer Survivors
2021
The growing body of research on compassion has demonstrated its benefits for healthcare and wellbeing. However, there is no clear agreement about a definition for compassion, given the novelty of the research on this construct and its religious roots. The aim of this study is to analyze the mental semantic construction of compassion in Spanish-speaking women breast cancer survivors, and the effects of the Cognitively-Based Compassion Training (CBCT®) on the modification of this definition, compared to treatment-as-usual (TAU), at baseline, post-intervention, and six-month follow-up. Participants were 56 women breast cancer survivors from a randomized clinical trial. The Osgood''s Semantic D…
Hronotops A. Manfeldes romānā “Vilcēni”, A. Jundzes romānā “Sarkanais dzīvsudrabs” un J. Joņeva romānā “Jelgava 94”
2022
Maģistra darba “Hronotops A. Manfeldes romānā “Vilcēni”, A. Jundzes romānā “Sarkanais dzīvsudrabs” un J. Joņeva romānā “Jelgava 94” mērķis ir raksturot un analizēt fiktīvo romānu 20. gadsimta 90. gadu laiktelpu Latvijā un citus ar to saistītus literāros hronotopus. Darba teorētiskajā daļā sniegts hronotopa teorētiskais ieskats, ieskats semiotiskajā un naratoloģijas pētniecības metodē; aplūkota hronotopa un romāna saistība; ieskats romānu recepcijā kritikā; sniegts ieskats kultūrvēsturiskajā situācijā un pilsētas laiktelpā. Pētījuma praktiskajā daļā tiek analizēts 20. gadsimta 90. gadu hronotops romānos caur naratīvu un kā tas atklājas caur dažādām semiotiskajām zīmēm pilsētvidē.
In Vivo Reprogramming for Brain and Spinal Cord Repair.
2015
AbstractCell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently,in vivoreprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence forin vivoreprogramming in the mouse pancreas, heart, and brain and spinal cord with …
Kind Kit Marlow –or Marely or Merlin: A reading of Anthony Burgess's A dead man in Deptford through the naming conventions applied in the novel
2010
The main concern of my thesis is to provide an account of the stylistic idiosyncrasies observed in the naming of the characters in Anthony Burgess's post-modernist historical novel A Dead Man in Deptford (Vintage, 1994), with special reference to the names applied to its protagonist, the Elizabethan poet and dramatist Christopher Marlowe. The interest in naming is occasioned by the salience given to personal names, defined as proper names borne by human or anthropomorphised nominata. Their prominence is the result of two things. First, some names in the novel display a marked tendency to change form so that the same name appears under a variety of spellings, notably the protagonist's family…
La Edad Media contemporánea : estudio de la novela española de tema medieval (1990-2012)
2013
La tesis doctoral La Edad Media contemporánea. Estudio de la novela española de tema medieval (1990-2012) analiza la eclosión de la Edad Media en la novela española contemporánea, a través de un catálogo, formado por más de medio millar de títulos ambientados en el medievo o que lo convierten en un motivo a través del cual articulan sus tramas. Se ofrece una tipología que da cuenta de los modelos textuales más seguidos en los últimos años, así como un análisis de los motivos que han convertido en la narrativa de tema medieval en la más vendida y divulgada en nuestro país, y un detallado estudio de lo que bien puede denominarse narrativa templaria, pues, sin lugar a dudas, la Orden del Templ…
Sobre el desequilibrio económico en materia de pensión compensatoria : Algunas novedades jurisprudenciales. Comentario a las ssts núm. 495/2019, de 2…
2021
This paper analyses some jurisprudential novelties about the economic imbalance that give the right to receive the compensatory allowance in case of separation or divorce.