Search results for "nucleotide polymorphisms"

showing 5 items of 35 documents

Second report on chicken genes and chromosomes 2005.

2005

International audience

medicine.medical_specialtyChickens/genetics[SDV]Life Sciences [q-bio]Single-nucleotide polymorphismAnimal Breeding and Genomicsin-situ hybridizationMajor histocompatibility complexChromosomes5S ribosomal RNAMolecular geneticssingle-nucleotide polymorphismsMHC class IGeneticsmedicineAnimalsmhc class-itranslation initiation factor-4aFokkerij en GenomicaCYTOGENETIC MAPSMolecular BiologyGeneexpressed sequence tagsGenetics (clinical)ComputingMilieux_MISCELLANEOUSnucleolar-size polymorphismsGeneticsExpressed sequence tagCHICKENSModels GeneticbiologyChromosomes/geneticsdt40 cell-linetelomerase rna genemajor histocompatibility complexHuman genetics[SDV] Life Sciences [q-bio]GENETIC MAPS5s ribosomal-rnaWIASbiology.protein
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SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study

2020

The course of SARS-CoV-2 infection ranges from asymptomatic to a multiorgan disease. In this observational study, we investigated SARS-CoV-2 infected subjects with defined outcomes, evaluating the relationship between viral load and single nucleotide polymorphisms of genes codifying for IFN&lambda

medicine.medical_specialtyCoronavirus disease 2019 (COVID-19)viruseslcsh:MedicineSingle-nucleotide polymorphismDiseaseSettore MED/42 - Igiene Generale E ApplicataLower riskAsymptomaticGastroenterologyArticle03 medical and health sciencessingle nucleotide polymorphisms0302 clinical medicinesingle nucleotide polymorphismSettore BIO/13 - Biologia ApplicataInterferonIFNλsInternal medicinemedicine030212 general & internal medicineskin and connective tissue diseasesCOVID-19 outcome030304 developmental biologySettore MED/12 - Gastroenterologia0303 health sciencesbusiness.industrySARS-CoV-2fungilcsh:RIFNλGeneral Medicinerespiratory tract diseasesCOVID-19 outcomesviral loadbody regionsObservational studymedicine.symptombusinessViral loadmedicine.drugJournal of Clinical Medicine
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Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder

2017

Background Posttraumatic stress disorder (PTSD) is a severe problem among soldiers with combating experience difficult to treat. The pathogenesis is still not fully understood at the psychological level. Therefore, genetic research became a focus of interest. The identification of single nucleotide polymorphisms (SNPs) may help to predict, which persons are at high risk to develop PTSD as a starting point to develop novel targeted drugs for treatment. Methods We conducted a systematic review on SNPs in genes related to PTSD pathology and development of targeted pharmacological treatment options based on PubMed database searches. We focused on clinical trials with military personnel. Results…

medicine.medical_specialtyPopulationTropomyosin receptor kinase BBioinformaticsArticleStress Disorders Post-Traumatic03 medical and health sciencessingle nucleotide polymorphisms0302 clinical medicinePharmacotherapyDopamineDopamine receptor D2medicineAnimalsHumansPharmacology (medical)geneticsGenetic Predisposition to DiseaseReceptorPsychiatryeducationeducation.field_of_studyClinical Trials as Topicbusiness.industryTraumatic stressGeneral MedicineDNAgene-environment interactions030227 psychiatryPsychiatry and Mental healthMilitary PersonnelNeurologyGene-Environment InteractionNeurology (clinical)pharmacologybusinessmental diseases030217 neurology & neurosurgeryPharmacogeneticsmedicine.drugCurrent Neuropharmacology
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Genome-wide analysis of Italian sheep diversity reveals a strong geographic pattern and cryptic relationships between breeds

2014

Summary Italy counts several sheep breeds, arisen over centuries as a consequence of ancient and recent genetic and demographic events. To finely reconstruct genetic structure and relationships between Italian sheep, 496 subjects from 19 breeds were typed at 50K single nucleotide polymorphism loci. A subset of foreign breeds from the Sheep HapMap dataset was also included in the analyses. Genetic distances (as visualized either in a network or in a multidimensional scaling analysis of identical by state distances) closely reflected geographic proximity between breeds, with a clear north–south gradient, likely because of high levels of past gene flow and admixture all along the peninsula. Sa…

multidimensional scalingOvis ariesGenotypeanalysisIntrogressionContext (language use)BiologyBreedinggenetic diversity; genetic structure; genome-wide single nucleotide polymorphisms; multidimensional scaling; neighbor network; Ovis aries; oviniPolymorphism Single Nucleotidegenome-widegenome-wide single nucleotide polymorphisms; multidimensional scaling; neighbor networksingle nucleotide polymorphismsgenetic diversity; genetic structure; genome-wide; single nucleotide polymorphisms; multidimensional scaling; neighbor network; Ovis ariesGeneticsgenetic structureAnimalsneighbor networkInternational HapMap ProjectGeneticsGenetic diversityGenomeSheepSettore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICOgenome-wide single nucleotide polymorphismsGenetic VariationGeneral Medicinegenetic diversitybiology.organism_classificationBreedMouflonPhylogeographyItalyEvolutionary biologyoviniGenetic structureAnimal Science and ZoologyrevealsGenetic isolate
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Genomic Tools for the Characterization of Local Animal Genetic Resources: Application in Mascaruna Goat

2022

Italy contains a large number of local goat populations, some of which do not have a recognized genetic structure. The “Mascaruna” is a goat population reared for milk production in Sicily. In this study, a total of 72 individuals were genotyped with the Illumina Goat_IGGC_65K_v2 BeadChip with the aim to characterize the genetic diversity, population structure and relatedness with another 31 Italian goat populations. The results displayed a moderate level of genetic variability for Mascaruna, in concordance with the estimated values for Italian goats. Runs of homozygosity islands are linked to genes involved in milk production, immune response and local adaptation. Population structure anal…

single nucleotide polymorphismsSettore AGR/17 - Zootecnica Generale E Miglioramento Geneticolocal goat; single nucleotide polymorphisms; genetic structuregenetic structure local goat single nucleotide polymorphismsGeneral Veterinarygenetic structureAnimal Science and Zoologylocal goat
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