Search results for "nucleus"
showing 3 items of 1803 documents
Quantitative microscopy reveals stepwise alteration of chromatin structure during herpesvirus infection
2019
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation of channels through the compacted peripheral chromatin. Here, we used three-dimensional confocal and expansion microscopy, soft X-ray tomography, electron microscopy, and random walk simulations to analyze the kinetics of host chromatin redistribution and capsid localization relative to their egress site at the nuclear envelope. Our data demonstrated a gradual increase in chromatin marginalization, and the kinetics of chromatin smoothening arou…
Anatomical and electrophysiological study of the vomeronasal circuits: Amygdaloid response to odours and pheromones
2017
Rodents detect information concerning the world around them mainly through two chemosensory systems: the olfactory and the vomeronasal systems. In order to develop an appropriate behavioural response to their environment, these systems exhibit both functional and physiological convergence. Further understanding of the organization and function of the olfactory systems would allow us to comprehend how their information is integrated in the brain. In a first approach we performed a thorough analysis of the connections of key structures involved in the processing of vomeronasal information: the medial (Me) and the posteromedial cortical (PMCo) amygdaloid nucleus. Then, we enquire the populatio…
Search for inelastic scattering of WIMP dark matter in XENON1T
2021
We report the results of a search for the inelastic scattering of weakly interacting massive particles (WIMPs) in the XENON1T dark matter experiment. Scattering off $^{129}$Xe is the most sensitive probe of inelastic WIMP interactions, with a signature of a 39.6 keV de-excitation photon detected simultaneously with the nuclear recoil. Using an exposure of 0.89 tonne-years, we find no evidence of inelastic WIMP scattering with a significance of more than 2$\sigma$. A profile-likelihood ratio analysis is used to set upper limits on the cross-section of WIMP-nucleus interactions. We exclude new parameter space for WIMPs heavier than 100 GeV/c${}^2$, with the strongest upper limit of $3.3 \time…