Search results for "obese"

The relationship between the rheological behavior of RBCs and angiogenesis in the morbidly obese

2018

OBJECTIVE The aim of this study was to investigate the relationship between red blood cell (RBC) aggregation and deformability and angiogenesis parameters in obese patients. METHODS We studied 35 obese subjects and 20 non-obese people as a control group. Angiogenesis was detected using Bio-Plex Pro Human Angiogenesis Multiplex Assays. The RBC aggregation and deformability of the red blood cell aggregation were performed by the Laser-assisted Optical Rotational Cell Analyser - LORCA. RESULTS The aggregation index and the syllectogram's amplitude were significantly higher in the obese patients, whereas the aggregation half-time (t1/2) was lower compared with the control group. The deformabili…

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.

2012

Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leading to the progression of NASH. This study aimed at identifying whether silibinin may influence the molecular events of lipotoxicity in a mouse model of NASH. Eight-week-old db/db mice were fed a methionine-choline deficient (MCD) diet for 4 weeks and treated daily with silibinin (20 mg/kg intraperitoneally) or vehicle. Liver expression and enzyme activity of stearoyl-CoA desaturase-1 and acyl-CoA oxidase, and expression of liver fatty acid-binding protein were assessed. Hepatic levels of reactiv…

Alterations in the Hippocampal Endocannabinoid System in Diet-Induced Obese Mice

2010

The endocannabinoid (eCB) system plays central roles in the regulation of food intake and energy expenditure. Its alteration in activity contributes to the development and maintenance of obesity. Stimulation of the cannabinoid receptor type 1 (CB1receptor) increases feeding, enhances reward aspects of eating, and promotes lipogenesis, whereas its blockade decreases appetite, sustains weight loss, increases insulin sensitivity, and alleviates dysregulation of lipid metabolism. The hypothesis has been put forward that the eCB system is overactive in obesity. Hippocampal circuits are not directly involved in the neuronal control of food intake and appetite, but they play important roles in hed…

MENTAL FUNCTIONING IN A GROUP OF OBESE PATIENTS CANDIDATES FOR BARIATRIC TREATMENT: DEFENCE MECHANISMS AND ALEXITHYMIA

2017

Several studies confirm that obesity with comorbidity psychiatric disorders decreases the long-term success of surgical treatment. The prevalence of psychiatric disorders varies from 30% to 76% between the obese patients candidate for bariatric treatment (Hudson et al., 2007; Striegel-Moore et al., 2009). It goes without saying that it is essential to prearrange a correct assessment in patient with a severe obesity who are candidate for surgical treatment in order to ensure a long term successful treatment. The aim of the study is to outline some psychological factors that could promote and maintain conditions of severe obesity and to identify weak points in widely applied care pathway. Thi…

Merits and differences between single-site robotic and laparoscopic cholecystectomy: What is unfair? Commentary on "Propensity score-matching analysi…

2020

OBESITY AND EMOTIONAL AROUSAL AND CONTROL IN CHILDREN AGED 8 TO 11 YEARS

2018

The purpose of this study is to present the results obtained in the base of the opinion of 95 children from general schools of Sibiu city in Romania, collected during a survey regarding emotional reactivity (arousal) and regulatory capacity (control) in early adolescence. Data were stratified by BMI in order to analyze the relationship between obesity and emotional arousal and control in case of young adolescents. A 30-item self-reporting multidimensional instrument HIF (How I Feel) created by Walden, Harris & Carton in 2003 was used. The questionnaire items refer to five different emotions: happy, sad, excited, scared and mad. Significant differences between the three subgroups (normal wei…

Anesthesiological Particularities in Bariatric Surgery

2011

Morbid obesity has become a global pandemic in recent years: 5% of the adult population of the USA are considered morbidly obese, i.e., have a BMI that exceeds 40. Every 90 seconds a US American dies of obesity and its consequences – making 1,000 people every day and 400,000 a year. This explains the dramatic rise of interest in bariatric procedures and with it in suitable anesthesiological methods.

Emerging approaches for the treatment of hypertriglyceridemia.

2013

Hypertriglyceridemia is frequent in diabetic and obese subjects, who are at increased risk for cardiovascular diseases (CVD). Increased triglycerides (TG) are a hallmark of atherogenic dyslipidemia, representing a marker of atherogenic small dense low-density lipoproteins (sdlDL). Importantly, non-fasting/postprandial TG measurements tend to be emphasized in clinical practice for the prediction of CVD, and TG-lowering agents (primarily fibrates) have a beneficial effect on atherogenic dyslipidemia, reducing TG-rich particles and ultimately lowering the production of sdlDL. The combination of omega-3 fatty acids and statins is also recommended, and widely used in clinical practice for subjec…

Distribution of ventilation and oxygenation in surgical obese patients ventilated with high versus low positive end-expiratory pressure: A substudy o…

2022

BACKGROUND Intra-operative ventilation using low/physiological tidal volume and positive end-expiratory pressure (PEEP) with periodic alveolar recruitment manoeuvres (ARMs) is recommended in obese surgery patients.OBJECTIVES To investigate the effects of PEEP levels and ARMs on ventilation distribution, oxygenation, haemodynamic parameters and cerebral oximetry.DESIGN A substudy of a randomised controlled trial.SETTING Tertiary medical centre in Geneva, Switzerland, between 2015 and 2018.PATIENTS One hundred and sixty-two patients with a BMI at least 35 kg per square metre undergoing elective open or laparoscopic surgery lasting at least 120 min.INTERVENTION Patients were randomised to PEEP…

Micro-albuminuria in obese subjects: relationship among body fat distribution, blood pressure and left ventricular structure and function.

1998

OBJECTIVE: To evaluate the relationships among micro-albuminuria, blood pressure and measurements of left ventricular structure and function in centrally and peripherally obese subjects compared with members of a lean control group. METHODS: Centrally obese subjects were subdivided according to whether they had levels of micro-albuminuria higher than 30 mg/24 h (micro-albuminuric group) or lower than or equal to 30 mg/24 h (normo-albuminuric group). For all the subjects we measured heart rate, casual mean blood pressure (MBP), 24 h MBP, total cholesterol level, high-density lipoprotein cholesterol, lipoprotein (a) level, fasting immunoreactive insulin level, plasma renin activity, plasma al…