Search results for "object"

A Multimodal Speech-Gesture Training Intervention for Patients With Schizophrenia and Its Neural Underpinnings – the Study Protocol of a Randomized C…

2020

Dysfunctional social communication is one of the most stable characteristics in patients with schizophrenia that also affects quality of life. Interpreting abstract speech and integrating nonverbal modalities is particularly affected. Considering the impact of communication on social life but failure to treat communication dysfunctions with usual treatment, we will investigate the possibility to improve verbal and non-verbal communication in schizophrenia by applying a multimodal speech-gesture training (MSG training). Here we describe the newly developed MSG training program and the study design for the first clinical investigation. The intervention contains perceptive rating (match/mismat…

Airway assessment by four-phase rhinomanometry in septal surgery

2011

PURPOSE OF REVIEW This article updates the state of the art in functional ventilation tests of the nasal airway. Multidisciplinary international cooperation has led within the last years to the development of four-phase rhinomanometry (4PR) by eradicating the errors of the 'classic' rhinomanometry. RECENT FINDINGS Physical experiments, mathematical models and comprehensive statistical analyses implicate that the nasal breath consists of four phases of different diagnostic importance. Presuming the motility of the nasal entrance, it is necessary to depict the elastic behavior within the rhinomanometric curve, as well as to use new parameters for the clinical evaluation of the nasal obstructi…

RANDOMIZED PHASE II STUDY OF FIRST-LINE EVEROLIMUS (EVE) + BEVACIZUMAB (BEV) VERSUS INTERFERON ALFA-2A (IFN) + BEV IN PATIENTS (PTS) WITH METASTATIC …

2012

ABSTRACT Background Study results demonstrated that IFN augments BEV activity and improves median PFS in pts with mRCC. Thus, combination BEV + IFN is a standard first-line treatment option for mRCC. Combining BEV with the mTOR inhibitor EVE may be an efficacious and well-tolerated treatment option. The open-label, phase II RECORD-2 trial compared first-line EVE + BEV and IFN + BEV in mRCC. Patients and methods: Therapy-naive pts with clear cell mRCC and prior nephrectomy were randomized 1:1 to BEV 10 mg/kg IV every 2 weeks with either EVE 10 mg oral daily or IFN (9 MIU SC 3 times/week, if tolerated). Tumour assessments were every 12 weeks. Primary objective was treatment effect on progress…

La calidad en la gestión de los Servicios Sociales Municipales: algunas experiencias de INTRESS

2011

Queremos presentar en este breve artículo dos experiencias de INTRESS en el desarrollo de buenas prácticas que puedan ayudar a la implantación de sistemas de gestión de calidad en las administraciones locales así como en organizaciones y entidades del Tercer Sector. Se expone pues, por un lado, la experiencia desarrollada en la Concejalía de Acción Social, Mujer y Familia del Ayuntamiento de Valdemoro (Madrid) a través de la formación de sus profesionales en la gestión por procesos y la mejora continua y por otro lado, la iniciativa 'Indicadores Sociales' desarrollada por la red de Consultoría Social, para el desarrollo de una Web de indicadores sociales que permita compartir resultados y b…

Neokantysta w laboratorium psychologicznym - Richarda Hönigswalda poszukiwanie zasad bytu psychicznego

2019

The specificity of Richard Hӧnigswald’s attitude to the issues raised in the Neo-Kantian philosophy was clearly visible in his approach to psychology. First of all, this covered the question of the objectivity of cognizance. Like other Neo-Kantian philosophers, Hӧnigswald undertook in his work both the problem of the relationship between philosophy and psychology and the problem of psychol- ogism. Unlike the representants of both Neo-Kantians schools, he took up psych- ology practically. In the years 1916–1930 he led the psychological laboratory of the Philosophical Seminar at the University of Wrocław, where he conducted a study of the process of thinking. Hӧnigswald took up psychology as …

Reusable digital learning material production

2003

A Multiple Surrogate Assisted Decomposition Based Evolutionary Algorithm for Expensive Multi/Many-Objective Optimization

2019

Many-objective optimization problems (MaOPs) contain four or more conflicting objectives to be optimized. A number of efficient decomposition-based evolutionary algorithms have been developed in the recent years to solve them. However, computationally expensive MaOPs have been scarcely investigated. Typically, surrogate-assisted methods have been used in the literature to tackle computationally expensive problems, but such studies have largely focused on problems with 1–3 objectives. In this paper, we present an approach called hybrid surrogate-assisted many-objective evolutionary algorithm to solve computationally expensive MaOPs. The key features of the approach include: 1) the use of mul…

Sectoral policies as drivers of forest management and ecosystems services: A case study in Bavaria, Germany

2023

European countries have national sectoral polices to regulate and promote the provision of a wide range of forest ecosystems services (FES). However, potential incoherencies among these policies can negatively affect the efficient provision of FES. In this work, we evaluated the coherence among three national policies from Germany and their ability to effectively provide FES in the future: the Forest Strategy 2020 (FS), the National Strategy on Biological Diversity (BDS), and the German National Policy Strategy on Bioeconomy (BES). Using forest inventory data from the Federal State of Bavaria, we simulated a range of forest management options under three climate trajectories for 100 years i…

Trade-offs among intensive forestry, ecosystem services and biodiversity in boreal forests

2018

Finnish forests are used extensively for timber production but are also providers of other ecosystem services and harbor unique biodiversity. The ecosystem services approach has so far been used marginally in the context of Finnish forestry; however, due to the multiple values associated with Finnish forests and the impacts forestry operations have on forest ecosystems, it is clearly applicable in this context. In this thesis, I studied the occurrence and severity of trade-offs among ecosystem services and biodiversity conservation in Finnish forests. I used forest inventory data, forest growth simulations, and multi-objective optimization to reveal how the severity of the trade-offs varies…

Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition

2023

: Corticosteroid-mediated stress responses require the activation of complex brain circuits involving mitochondrial activity, but the underlying cellular and molecular mechanisms are scantly known. The endocannabinoid system is implicated in stress coping, and it can directly regulate brain mitochondrial functions via type 1 cannabinoid (CB1) receptors associated with mitochondrial membranes (mtCB1). In this study, we show that the impairing effect of corticosterone in the novel object recognition (NOR) task in mice requires mtCB1 receptors and the regulation of mitochondrial calcium levels in neurons. Different brain circuits are modulated by this mechanism to mediate the impact of cortico…