Search results for "obp"
showing 10 items of 13 documents
Identification of a lysyl residue defining the binding specificity of a human odorant-binding protein
2008
International audience
Dianthus superbus as a critically endangered species in Latvia: evaluation of its growth conditions and conservation possibilities
2021
Abstract Dianthus superbus is one of the most endangered species in Latvia and is on the verge of local extinction. Therefore, the aim of this study was to inventory previously identified populations of D. superbus in Latvia and to develop activities to conserve this species in accordance with the results obtained in situ. Expeditions on 18 previously documented locations, according to the data of Nature Conservation Agency, revealed only three existing D. superbus localities in Latvia with a significant number of specimens located in the Latgale region near Silenieki. In 2020, for the first time, two more new D. superbus localities were found in the vicinity of these three approved locatio…
The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and …
2021
Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose to the tumor target but is generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) is a novel approach aimed at enhancing proton biological effectiveness. PBCT exploits a nuclear fusion reaction between low-energy protons and 11B atoms, i.e. p+11B→ 3α (p-B), which is supposed to produce highly-DNA damaging α-particles exclusively across the tumor-conformed Spread-Out Bragg Peak (SOBP), without harming healthy tissues in the beam entrance channel. To confirm previous work on PBCT, here we report new in-vitro data obtained…
Structure of rat odorant-binding protein OBP1 at 1.6 angstrom resolution
2009
The nasal mucosa is a specialist interfacial region sandwiched between the olfactory system and the gaseous chemical milieu. In mammals and insects, this region is rich in odorant-binding proteins that are thought to aid olfaction by assisting mass transfer of the many different organoleptic compounds that make up the olfactory landscape. However, in mammals at least, our grasp on the exact function of odorant-binding proteins is tentative and better insight into the role of these proteins is warranted, not least because of their apparent significance in the olfactory systems of insects. Here, the crystal structure of rat odorant-binding protein 1 is reported at 1.6 Å resolution. This prote…
Xenopus Laevis and Xenopus Tropicalis have different number of OBP genes : Xlaeobp and Xtroobp
2008
International audience
Two novel members of OBP family identified in the honeybee : sexual dimorphism and development studies
1998
International audience
DOSIMETRIA ESR CON ALANINA PER ADRONTERAPIA CON IONI CARBONIO
2015
La sicurezza del paziente sottoposto a trattamenti terapeutici con radiazioni ionizzanti e il buon esito degli ultimi sono strettamente legati all’ottimizzazione delle procedure di esposizione alle radiazioni ionizzanti. In particolare è fondamentale arrecare il danno minore possibile ai tessuti sani che circondano la neoplasia da trattare. Rispetto ai campi di radiazione convenzionali utilizzati in radioterapia (fotoni), le particelle cariche pesanti (protoni e ioni carbonio) offrono diversi vantaggi quali la bassa dispersione laterale, l’alta efficacia biologica (RBE) nella regione del picco di Bragg ed un profilo di dose caratteristico in profondità del tutto differente da quello dei fot…
Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study
2017
Abstract Background Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers an increased risk of premature atherosclerotic cardiovascular disease. Early identification and treatment of FH patients can improve prognosis and reduce the burden of cardiovascular mortality. Aim of this study was to perform the mutational analysis of FH patients identified through a collaboration of 20 Lipid Clinics in Italy (LIPIGEN Study). Methods We recruited 1592 individuals with a clinical diagnosis of definite or probable FH according to the Dutch Lipid Clinic Network criteria. We performed a parallel sequencing of the major…
De l’ingénierie de protéines de liaison aux odorants à la détection électrochimique de molécules volatiles vers la conception de biocapteurs et nez é…
2014
The detection of odorant molecules has become an important challenge in different research area, such as the food industry, medical diagnostics and homeland security. Indeed, the thousands of odorants in our environment provide information on their chemical nature or their concentration. Human olfactory system is capable of discriminating thousands of different molecules thanks to biochemical mechanisms involving multiple protein receptor partners and a combinatorial coding. These biomolecules that include olfactory receptors and odorant-binding proteins (OBP) represent an interesting source of detectors for the design of biosensors. OBPs are small soluble proteins present in nasal mucus at…
Novel canine odorant binding proteins
2022
The present invention relates to the use of a sequence chosen among Seq ID No 3, Seq ID No l, Seq ID No 2, Seq ID No 4, Seq ID No 5, Seq ID No 6, Seq ID No 7, Seq ID No 8, and functional variants thereof, as an odorant binding protein (OBP).