Search results for "obstruction"
showing 10 items of 260 documents
Comparison of heparin to citrate as a catheter locking solution for non-tunneled central venous hemodialysis catheters in patients requiring renal re…
2014
Background The incidence of acute kidney injury (AKI) is estimated at 10 to 20% in patients admitted to intensive care units (ICU) and often requires renal replacement therapy (RRT). ICU mortality in AKI patients can exceed 50%. Venous catheters are the preferred vascular access method for AKI patients requiring RRT, but carry a risk of catheter thrombosis or infection. Catheter lock solutions are commonly used to prevent such complications. Heparin and citrate locks are both widely used for tunneled, long-term catheters, but few studies have compared citrate versus heparin for patients with short-term, non-tunneled catheters. We aim to compare citrate 4% catheter lock solution versus hepar…
Augmented Package of Palliative Care for Women With Cervical Cancer: Responding to Refractory Suffering
2021
The essential package of palliative care for cervical cancer (EPPCCC), described elsewhere, is designed to be safe and effective for preventing and relieving most suffering associated with cervical cancer and universally accessible. However, it appears that women with cervical cancer, more frequently than patients with other cancers, experience various types of suffering that are refractory to basic palliative care such as what can be provided with the EPPCCC. In particular, relief of refractory pain, vomiting because of bowel obstruction, bleeding, and psychosocial suffering may require additional expertise, medicines, or equipment. Therefore, we convened a group of experienced experts in…
Invariant deformation theory of affine schemes with reductive group action
2015
We develop an invariant deformation theory, in a form accessible to practice, for affine schemes $W$ equipped with an action of a reductive algebraic group $G$. Given the defining equations of a $G$-invariant subscheme $X \subset W$, we device an algorithm to compute the universal deformation of $X$ in terms of generators and relations up to a given order. In many situations, our algorithm even computes an algebraization of the universal deformation. As an application, we determine new families of examples of the invariant Hilbert scheme of Alexeev and Brion, where $G$ is a classical group acting on a classical representation, and describe their singularities.
Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-C…
2022
Patients with nonclassic phenotypes (NCP)—more advanced stages of hypertrophic cardiomyopathy (HCM)—constitute an intriguing and heterogeneous group that is difficult to diagnose, risk-stratify, and treat, and often neglected in research projects. We aimed to compare cardiac magnetic resonance (CMR) parameters in NCP versus classic phenotypes (CP) of HCM with special emphasis given to the parameters of established and potential prognostic importance, including numerous variables not used in everyday clinical practice. The CMR studies of 88 patients performed from 2011 to 2019 were postprocessed according to the study protocol to obtain standard and non-standard parameters. In NCP, the late …
Congenital reduction in number of nephrons accelerates renal damage, and limits proximal tubular growth response to release of neonatal partial urete…
2012
Aim: to analyze the evolution of the response to persistent partial ureteral obstruction (PUO) and obstruction/release (PUO/Rel) in mice with 50% reduction in the number of nephrons from 21 days of age (time of weaning) to 42 days of age (adulthood). Methods: C57/BL6 wild-type (WT) and mice with oligosyndactylism and 50% reduction of nephron number (Os/+), were subjected to sham operation or PUO in the first 2 days of life. Additional mice underwent release of obstruction at 7 days (PUO-Rel). The study was performed in kidneys harvested at 21 and 42 days. Using histomorphometry, glomerular area (GA) was determined by PAS staining, and fractional proximal tubular (PT) mass and intact glomeru…
URINARY TRACT OBSTRUCTION AND REDUCED NEPHRON NUMBER: ADAPTATION OF NEPHRONS FOLLOWED THROUGH ADULTHOOD IN A MOUSE MODEL
2015
Congenital urinary tract obstruction , NEPHRON NUMBER, MOUSE MODEL , release of obstruction
CONGENITAL REDUCTION IN NUMBER OF NEPHRONS IMPAIRS PROXIMAL TUBULAR GROWTH IN THE CONTRALATERAL KIDNEY DURING PARTIAL UNILATERAL URETERAL OBSTRUCTION
2013
PURPOSE To compare the response of the contralateral (CL) kidney during partial unilateral uretaral obstruction (PUO) and from obstruction/release (PUO/Rel) to sham-operated kidneys in both wild-type (WT) mice and mice with 50% reduction of nephron number (Os/+) MATERIAL AND METHODS C57/BL6 WT and mice with oligosyndactylism and 50% reduction of nephron number (Os/+), were subjected to sham operation or PUO in the first 2 days of life. Additional mice underwent release of obstruction at 7 days (PUO-Rel). All kidneys were harvested at 6 weeks (adulthood). Using histomorphometry, glomerular number and area were determined by PAS staining, and proximal tubular (PT) mass and injury to the glome…
Role of antibiotic prophylaxis in antenatal hydronephrosis: A systematic review from the European Association of Urology/European Society for Paediat…
2017
Summary Background The benefits and harms of continuous antibiotic prophylaxis (CAP) versus observation in patients with antenatal hydronephrosis (ANH) are controversial. Objective The aim was to determine the effectiveness of CAP for ANH, and if beneficial to determine the best type and regimen of antibiotic and the most harmful to provide guidance for clinical practice. Methods A systematic literature search was performed in databases including Medline, Embase, and Cochrane in June 2015. The protocol was prospectively registered to PROSPERO (CRD42015024775). The search started from 1980, when maternal ultrasound was first introduced into clinical practice. Eligible studies were critically…
Deguna vārsta kustīguma kvantitatīvo noteikšanas metožu salīdzinoša analīze
2019
Ievads 4-fāžu rinomanometrija šobrīd ir vienīgā nazālo elpceļu funkcionalitātes mērīšanas metode, kura ņem vērā nazālo elpceļu elastīgās struktūras. Sekojot līdz jaunākajiem atklājumiem par to kā nazālās vārstules kustīgums iedarbojas jau agri elpošanas ciklā, fundamentāli ir izveidot ilgtspējīgu diagnostikas instrumentu, kas mēra nazālo elpceļu elastīgās struktūras, it īpaši deguna vārstules. Mērķis Šī pilotpētījuma mērķis ir virzīt uz priekšu zinātnisko pētniecību fizioloģiskas un patoloģiskas deguna gaisa plūsmas diagnostikā. Mērķis ir attīstīt provizoriskas mērīšanas tehnikas, kas veicinātu nazālās vārstules elastogrāfijas ierīces ieviešanu medicīnā. Materiāli un metodes Tika testēti da…
MODULATION OF BLADDER α1-ADRENERGIC RECEPTOR SUBTYPE EXPRESSION BY BLADDER OUTLET OBSTRUCTION
2002
Purpose: α1-Adrenergic receptor (α1AR) antagonists are effective for relieving obstructive and irritative symptoms in patients with bladder outlet obstruction. While the α1aAR is responsible for prostate smooth muscle relaxation and outlet obstruction relief, to our knowledge the mechanisms underlying the relief of irritative symptoms remain to be determined. Therefore, we investigated mechanisms by which bladder α1AR subtypes may be involved in this process.Materials and Methods: We studied 42 rats, including 6 unoperated controls, 17 sham operated controls and 19 obstructed animals. Animals were characterized for baseline voiding pattern, followed by surgical intervention or sham surgery …