Search results for "oftware"
showing 10 items of 7396 documents
PyCellBase, an efficient python package for easy retrieval of biological data from heterogeneous sources.
2019
Background Biological databases and repositories are incrementing in diversity and complexity over the years. This rapid expansion of current and new sources of biological knowledge raises serious problems of data accessibility and integration. To handle the growing necessity of unification, CellBase was created as an integrative solution. CellBase provides a centralized NoSQL database containing biological information from different and heterogeneous sources. Access to this information is done through a RESTful web service API, which provides an efficient interface to the data. Results In this work we present PyCellBase, a Python package that provides programmatic access to the rich RESTfu…
Analysis of Lipid Experiments (ALEX): A Software Framework for Analysis of High-Resolution Shotgun Lipidomics Data
2013
Global lipidomics analysis across large sample sizes produces high-content datasets that require dedicated software tools supporting lipid identification and quantification, efficient data management and lipidome visualization. Here we present a novel software-based platform for streamlined data processing, management and visualization of shotgun lipidomics data acquired using high-resolution Orbitrap mass spectrometry. The platform features the ALEX framework designed for automated identification and export of lipid species intensity directly from proprietary mass spectral data files, and an auxiliary workflow using database exploration tools for integration of sample information, computat…
Local dimensionality reduction and supervised learning within natural clusters for biomedical data analysis
2006
Inductive learning systems were successfully applied in a number of medical domains. Nevertheless, the effective use of these systems often requires data preprocessing before applying a learning algorithm. This is especially important for multidimensional heterogeneous data presented by a large number of features of different types. Dimensionality reduction (DR) is one commonly applied approach. The goal of this paper is to study the impact of natural clustering--clustering according to expert domain knowledge--on DR for supervised learning (SL) in the area of antibiotic resistance. We compare several data-mining strategies that apply DR by means of feature extraction or feature selection w…
A brief history of the formation of DNA databases in forensic science within Europe.
2001
The introduction of DNA analysis to forensic science brought with it a number of choices for analysis, not all of which were compatible. As laboratories throughout Europe were eager to use the new technology different systems became routine in different laboratories and consequently, there was no basis for the exchange of results. A period of co-operation then started in which a nucleus of forensic scientists agreed on an uniform system. This collaboration spread to incorporate most of the established forensic science laboratories in Europe and continued through two major changes in the technology. At each step agreement was reached on which systems to use. From the beginning it was realise…
Fuzzy technique for microcalcifications clustering in digital mammograms
2012
Abstract Background Mammography has established itself as the most efficient technique for the identification of the pathological breast lesions. Among the various types of lesions, microcalcifications are the most difficult to identify since they are quite small (0.1-1.0 mm) and often poorly contrasted against an images background. Within this context, the Computer Aided Detection (CAD) systems could turn out to be very useful in breast cancer control. Methods In this paper we present a potentially powerful microcalcifications cluster enhancement method applicable to digital mammograms. The segmentation phase employs a form filter, obtained from LoG filter, to overcome the dependence from …
Ligand-based discovery of novel trypanosomicidal drug-like compounds: In silico identification and experimental support
2010
Abstract Two-dimensional bond-based linear indices and linear discriminant analysis are used in this report to perform a quantitative structure–activity relationship study to identify new trypanosomicidal compounds. A database with 143 anti-trypanosomal and 297 compounds having other clinical uses, are utilized to develop the theoretical models. The best discriminant models computed using bond-based linear indices provides accuracies greater than 90 for both training and test sets. Our models identify as anti-trypanosomals five out of nine compounds of a set of already-synthesized substances. The in vitro anti-trypanosomal activity of this set against epimastigote forms of Trypanosoma cruzi…
Deployment of the ATLAS high level trigger
2005
The ATLAS combined test beam in the second half of 2004 saw the first deployment of the ATLAS high-level triggers (HLT). The next steps are deployment on the pre-series farms in the experimental area during 2005, commissioning and cosmics tests in 2006 and collisions in 2007. This paper reviews the experience gained in the test beam, describes the current status and discusses the further enhancements to be made. We address issues related to the dataflow, selection algorithms, testing, software distribution, installation and improvements
Combined Use of Rule-Based and Corpus-Based Methods in Machine Translation
2012
ANOTĀCIJA. Mašīntulkošanas (MT) sistēmas tiek būvētas izmantojot dažādas metodes (zināšanās un korpusā bāzētas). Zināšanās bāzēta MT tulko tekstu, izmantojot cilvēka rakstītus likumus. Korpusā bāzēta MT izmanto no tulkojumu piemēriem automātiski izgūtus modeļus. Abām metodēm ir gan priekšrocības, gan trūkumi. Šajā darbā tiek meklēta kombināta metode MT kvalitātes uzlabošanai, kombinējot abas metodes. Darbā tiek pētīta metožu piemērotība latviešu valodai, kas ir maza, morfoloģiski bagāta valoda ar ierobežotiem resursiem. Tiek analizētas esošās metodes un tiek piedāvātas vairākas kombinētās metodes. Metodes ir realizētas un novērtētas, izmantojot gan automātiskas, gan cilvēka novērtēšanas met…
Rediģējama darba laiku tabula ar administrācijas paneli Laravel 5.4 vidē
2018
Kvalifikācijas darba mērķis ir izstrādāt tīmekļa lietojumprogrammu – rediģējamu darba laiku tabulu ar administrācijas paneli Laravel 5.4 vidē medicīnas iestādes darba laika un kabinetu plānošanas nolūkiem. Kvalifikācijas darbs sastāv no vārdnīcas, ievada, programmatūras prasību specifikācijas, programmatūras projektējuma apraksta, testēšanas dokumentācijas, projekta organizācijas, konfigurācijas pārvaldības, kvalitātes nodrošināšanas, darbietilpības novērtējuma, secinājumiem un programmatūras pirmkoda un izpildkoda. Kvalifikācijas darba izstrādes laikā tika izstrādātā tīmekļa lietojumprogrammatūra – rediģējamā darba laiku tabula ir specifiski paredzēta pieņemšanas laiku plānošanai veselības…
Evaluation of Terra/MODIS atmospheric profiles product (MOD07) over the Iberian Peninsula: a comparison with radiosonde stations
2014
Remote sensing techniques are a useful tool for continuous observation of the Earth at global scale. However, products derived from remote sensing data require a rigorous validation using in situ data. Moderate Resolution Imaging Spectroradiometer (MODIS) is not really a sounding instrument, but it does have 16 infrared bands (bands 20–36 covering the spectral range from 3 µm to 14 µm) that allow the retrieval of temperature and moisture profiles as well as total column integrated magnitudes. In this paper we show the results obtained in the evaluation of MOD07 daytime and nighttime products over the Iberian Peninsula during the decade from 2000 to 2010 using nine radiosonde stations. Altho…