Search results for "ogas"
showing 10 items of 902 documents
Molecular Basis for the Regulation of Cell Fate by the Lethal (2) Giant Larvae Tumour Suppressor Gene of Drosophila Melanogaster
2007
Tumour suppressor genes act as recessive determinants of cancer. Their function is required for normal cell growth and differentiation during development. When both alleles of these developmental genes are inactivated, cell growth becomes unrestricted. In Drosophila, a series of genes have been identified which when mutated produce tissue-specific tumours. Of these the lethal(2)giant larvae (l(2)gl) gene is the best studied. Homozygous l(2)gl mutations cause the development of malignant tumours in the brain and the imaginal discs. Genomic DNA from the l(2)gl locus has been cloned, introduced back into l(2)gl mutant animals by P-element-mediated transformation and shown to restore normal dev…
A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube
2012
An important step in epithelial organ development is size maturation of the organ lumen to attain correct dimensions. Here we show that the regulated expression of Tenectin (Tnc) is critical to shape the Drosophila melanogaster hindgut tube. Tnc is a secreted protein that fills the embryonic hindgut lumen during tube diameter expansion. Inside the lumen, Tnc contributes to detectable O-Glycans and forms a dense striated matrix. Loss of tnc causes a narrow hindgut tube, while Tnc over-expression drives tube dilation in a dose-dependent manner. Cellular analyses show that luminal accumulation of Tnc causes an increase in inner and outer tube diameter, and cell flattening within the tube wall,…
Innovative and Applied Research in Biology: Proceedings, Vol. 3/2021
2021
The collection contains SCIENTIFIC articles on the topics of the LU 79 conference reports. The main focus is on innovative and applied research in biology and interdisciplinary fields.
MODELLING BIOGAS GENERATION AND RELEASE FROM MUNICIPAL SOLID WASTE LANDFILLS
2015
MSW sanitary landfills represent nowadays one of the most important issue related to the waste management cycle. In particular, knowledge about biogas production is a key aspect for a proper exploitation of this energy source, even in the after-care phase. In the present study, a simple mathematical model was proposed for the simulation of biogas production. The model is based on 1st order biodegradation kinetic and takes also into account the temperature variation in time and depth and the landfill settlement. The model was applied to a real landfill located in Sicily (ITALY) and its simulation result was compared with experimental data (volumes of biogas collected by the recovery system a…
DEVELOPMENT TRENDS OF BIOGAS
2015
All over the world, researches are made in order to improve the technologies, the operational and process stability and performance of biogas plants, because the world markets for biogas increased considerably in Europe and all over the world. In this paper we studied the most important parameters related to a biogas plant, starting from the ecologic landfill of Cristian, Sibiu, a landfill which storages industrial and household waste. In this respect, we studied operational parameters, such as organic load and hydraulic retention time, and parameters for evaluation of a biogas plant. Also, we made a case study concerning the evaluation of used waters in the landfill described above under t…
Potential production of biogas from prinkly pear (opuntia ficus-indica L.) in sicilian uncultivated areas
2017
The aim of this work is to evaluate the potential production of biogas and, indirectly, biomethane or electric and thermal energy, from prinkly pear (Opuntia ficus-indica L.), to be grown in a part of Sicilian uncultivated areas and co-digested together with the available livestock manure and slurry. In order to increase the Renewable Energy Sources (RES) and reduce the dependency from fossil ones, the conversion of biomass into biogas through Anaerobic Digestion (AD) process is paramount for producing biomethane, to be used as fuel for means of transport and agricultural machines or heating, or electric and thermal energy through Combined Heat and Power (CHP) plants. Moreover, the digestat…
Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
2015
ABSTRACT Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apopto…
cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
2020
Abstract Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited. Results To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located …
Evaluación del riesgo en humedales costeros mediterráneos de la presencia de contaminantes químicos orgánicos = Evaluation of the risk in Mediterrane…
2008
El rápido incremento de la población urbana ha traído asociado una intensa presión en el medioambiente circundante. Actualmente, la franja costera en la mayoría de países europeos es el área que ha experimentado un mayor desarrollo socioeconómico. Algunas pinceladas obtenidas de distintas fuentes dan una idea global de la importancia del crecimiento demográfico de estas zonas. Hoy en día, 3 mil millones de personas –alrededor de la mitad de la población mundial- viven a menos de 200 kilómetros de la costa. Dos quintas partes de las ciudades con poblaciones de entre 1 y 10 millones están localizadas cerca de la costa. En Bélgica, Portugal y España, la densidad de población en los 10 kilómetr…
Data from: How do cuticular hydrocarbons evolve? Physiological constraints and climatic and biotic selection pressures act on a complex functional tr…
2016
Cuticular hydrocarbons (CHCs) cover the cuticles of virtually all insects, serving as a waterproofing agent and as a communication signal. The causes for the high CHC variation between species, and the factors influencing CHC profiles, are scarcely understood. Here, we compare CHC profiles of ant species from seven biogeographic regions, searching for physiological constraints and for climatic and biotic selection pressures. Molecule length constrained CHC composition: long-chain profiles contained fewer linear alkanes, but more hydrocarbons with disruptive features in the molecule. This is probably owing to selection on the physiology to build a semi-fluid cuticular layer, which is necessa…