Search results for "oie"
showing 9 items of 1669 documents
Impacto del quimerismo hematopoyético precoz en el injerto tras trasplante alogénico de progenitores de sangre de cordón umbilical de donante no empa…
2013
El trasplante de sangre de cordón umbilical (TSCU) ha experimentado un auge muy importante en los últimos años como alternativa a la médula ósea y sangre periférica, debido a la dificultad de encontrar donantes altruistas de estas fuentes de progenitores hematopoyéticos. Los datos clínicos disponibles hasta la fecha muestran una supervivencia libre de enfermedad similar a la observada con el trasplante de médula ósea (TMO) o sangre periférica (TSP). Sin embargo, como consecuencia de la baja dosis celular contenida en la SCU, la tasa de fallo de injertos es más elevada y el tiempo hasta la recuperación de la neutropenia más prolongado. Gran parte de la investigación en el terreno del TSCU se…
Travestimenti, corpi e questioni di genere. I femminielli napoletani
2017
Il saggio riflette sulla costruzione del maschile e del femminile nell'ottica dell'antropopoiesi concentrandosi sul fenomeno dei femminilelli napoletani
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
L'Ecuba euripidea: dramma della violenza sugli inermi
2010
This paper focuses on ‘violence on unarmed people’ as the unifying theme that underlies the structure of the tragedy with an anthropopoietic function, what means to build up, by contrast, models of human and humanity.. All the three forms of violence against unarmed people, which can be singled out in the tragedy, are analyzed. The first is the sacred violence of Polyxena’s sacrifice, which is represented as an unnecessary and avoidable killing, due to the excessive power of the winners Greeks on losers barbarians. The second is the criminal violence upon Polydorus, motivated by greed for gold but also due to the impunity in a destructive war. The third is the ‘maenadic’ violence by which H…
Prefazione
2013
Mouse models of cytomegalovirus latency: overview.
2002
Abstract Background: The molecular regulation of viral latency and reactivation is a central unsolved issue in the understanding of cytomegalovirus (CMV) biology. Like human CMV (hCMV), murine CMV (mCMV) can establish a latent infection in cells of the myeloid lineage. Since mCMV genome remains present in various organs after its clearance from hematopoietic cells first in bone marrow and much later in blood, there must exist one or more widely distributed cell type(s) representing the cellular site(s) of enduring mCMV latency in host tissues. Endothelial cells and histiocytes are candidates, but the question is not yet settled. Another long debated problem appears to be solved: mCMV establ…
Tumor targeting of baculovirus displaying a lymphatic homing peptide.
2008
Background Tumor-associated cells and vasculature express attractive molecular markers for site-specific vector targeting. To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Methods In the present study, we explored the specificity and kinetics of viral binding and internalization as well as in vivo tumor homing of the LyP-1 displaying virus to elucidate the applicability of baculovirus for targeted therapies. Results We demonstrated that th…
Funkcjonowanie świetlic środowiskowych na rzecz przeciwdziałania wykluczeniu społecznemu dzieci i młodzieży na terenie miasta Opole
2015
Preo : pépinière de revues en open access
2022
PREO est une plateforme de publication de revues et de collections portée par la MSH de Dijon. Son équipe assure un accompagnement à l'édition scientifique multisupports dans le contexte de la Science ouverte. Depuis sa création, PREO accompagne des projets de transition de l'imprimé vers le numérique ou de création au format numérique natif. Dès 2021, PREO s'associe aux presses universitaires de Bourgogne (EUD) et de Franche-Comté (PUFC) dans le développement de bonnes pratiques au sein d'un pôle éditorial régional.