Search results for "omics"
showing 10 items of 17130 documents
National level wealth inequality and socioeconomic inequality in adolescent mental wellbeing
2020
Abstract Background Previous research established a positive association between national income inequality and socioeconomic inequalities in adolescent health, but little is known about the extent to which national level inequalities in accumulated financial resources (i.e. wealth) are associated with these health inequalities. Therefore, we examined the association between national wealth inequality and income inequality and socioeconomic inequalities in adolescent mental wellbeing. Methods Data were from 17 countries participating in three successive waves (2010, 2014 and 2018) of the cross-sectional Health Behaviour in School-aged Children (HBSC) study. We combined individual-level data…
The refugee entrepreneurship process from/in emerging economies
2021
The paper examines several refugee experiences in Mexico and presents their reasons for leaving their home countries. A gap in research is identifying the entrepreneurial process experienced by refugee entrepreneurs. We use the case study of 10 Latin American refugees in Mexico to propose a conceptual framework that describes the entrepreneurial process of refugee entrepreneurs. We have found that this process begins with the abandonment of the country of origin, followed by the traumatic experiences that caused flight and the difficulties they face in the pilgrimage to the host country. These events help shape the entrepreneurial intention of the refugees.
About the Use of Tag Questions in Andean Spanish
2021
This paper aims to describe the use of tag questions in the variety of Andean Spanish spoken in Bolivia. In particular, it explores the tag questions that occur in the Corpus oral del español hablado por bilingües de aymara-español. The analysis consists of two levels. On the one hand, it describes the pragmatic functions of tag questions and identifies the correlation between their distribution and their pragmatic functions. On the other hand, it focuses on the impact that social factors (the speakers’ sex, age, and education) have on the frequency of the tags. Along these lines, it displays the lack of a general sociolinguistic trend in the use of tag questions, furthermore, it shows that…
Organic matrices in metazoan calcium carbonate skeletons: composition, functions, evolution.
2016
9 pages; International audience; Calcium carbonate skeletal tissues in metazoans comprise a small quantity of occluded organic macromolecules, mostly proteins and polysaccharides that constitute the skeletal matrix. Because its functions in modulating the biomineralization process are well known, the skeletal matrix has been extensively studied, successively via classical biochemical approaches, via molecular biology and, in recent years, via transcriptomics and proteomics. The optimistic view that the deposition of calcium carbonate minerals requires a limited number of macromolecules has been challenged, in the last decade, by high-throughput approaches. Such approaches have made possible…
Agents of change: Women in top management and corporate environmental performance
2020
International audience; We analyze the influence of gender diversity in top management on the environmental performance of French firms. Consistent with gender socialization theory, which posits that women are raised from childhood to be more nurturing and compassionate for others, we find that firms with more women in top management exhibit higher environmental performance. This result extends those already reported in the literature regarding the effect of gender diversity at board level. We also show that women in top management are associated with several key indicators such as development of eco‐friendly products and commitment to resource reduction. Furthermore, we find that the influ…
Distritos industriales y renta económica: el efecto distrito – renta
2019
En el presente trabajo se expone una primera aproximación al efecto distrito desde la variable de la renta económica, lo que se ha denominado efecto distrito – renta. Esta aproximación al fenómeno distritural se realiza desde la perspectiva del desarrollo local neomarshalliano para enfatizar la centralidad del distrito industrial como fuente de interpretaciones propias sobre el cambio económico y sujeto activo del mismo. A nivel empírico se realiza una aproximación a la contrastación de la existencia o no de efecto distrito – renta en los distritos industriales españoles para el año 2013; estos datos son analizados a través de la comparativa de la renta total, per cápita y por ocupado expre…
A Knowledge Interface System for Information and Cyber Security Using Semantic Wiki
2018
Resilience against information and cyber security threats has become an essential ability for organizations to maintain business continuity. As bulletproof security is an unattainable goal, organizations need to concentrate to select optimal countermeasures against information and cyber security threats. Implementation of cyber risk management actions require special knowledge and resources, which especially small and medium-size enterprises often lack. Information and cyber security risk management establish knowledge intensive business processes, which can be assisted with a proper knowledge management system. This paper analyzes how Semantic MediaWiki could be used as a platform to assis…
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.
2008
ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodel…
New Perspective in Atrial Fibrillation
2020
International audience; Despite a large number of publications on this subject, the pathophysiological mechanisms involved in atrial fibrillation (AF) onset and recurrence are uncertain [...]
A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals i…
2011
Steatosis, or excessive accumulation of lipids in the liver, is a generally accepted previous step to the development of more severe conditions like nonalcoholic steatohepatitis, fibrosis, and cirrhosis. We aimed, to characterize the metabolic profile that defines simple steatosis in human tissue and to identify potential disturbances in the hepatic metabolism that could favor the switch to progressive liver damage. A total of 46 samples, 23 from steatotic and 23 from nonsteatotic human livers, were analyzed following a holistic LC-MS-based metabonomic analysis that combines RP and HILIC chromatographic separations. Multivariate statistical data analysis satisfactorily classified samples an…