Search results for "orf"
showing 10 items of 1406 documents
Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA(1-64)) in the rat heart
2010
Cytoskeleton scaffold in cardiac myocytes provides structural support and compartmentalization of intracellular components. It is implicated in cardiac pathologies including hypertrophy and failure, playing a key role in the determinism of contractile and diastolic dysfunctions. Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. In humans, normal CgA levels considerably increase in several pathologies, including heart failure. Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 (rCgA(1-64)) induce negative inotropic and lusitropic effects counteracting the beta-a…
Efficacia di Buprenorfina/Naloxone nel trattamento delle tossicodipendenze: monitoraggio dei pazienti in terapia presso il Ser.T. di Marsala, ASL n. …
2018
Il lavoro sperimentale è stato eseguito nel periodo gennaio 2016-marzo 2017, presso il Ser.T. di Marsala dell’ASL n. 9 di Trapani, sotto la guida del Dott. Gaetano Gurgone e del Prof. Fabio Venturella, lavoro in cui sono stati altresì analizzati i dati relativi agli ultimi cinque anni. Il compito prevalente del Ser.T. è l’assessment, inteso come processo di raccolta, integrazione ed interpretazione delle informazioni.Si esplica attraverso: la diagnosi, la cura, la riabilitazione. Questo lavoro vuole essere quindi il resoconto di 15 mesi di osservazione su pazienti trattati con Buprenorfina/Naloxone,operando un confronto con pazienti trattati con il Metadone.Il campione è costituito da 32 so…
Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease.
2016
Background. Rosai-Dorfmann disease (RDD) is a rare, idiopathic non-Langerhans cell histiocytosis, affecting children and young adults, that commonly presents as painless, massive cervical lymphadenopathy with fever, weight loss, and polyclonal hypergammaglobulinemia. Cervical lymphadenopathy and extranodal involvement are the main presentations. On the contrary, ophthalmic involvement and localisation in the central nervous system are rare.Case Report. An old man was admitted to our hospital for first seizure. Brain imaging studies revealed on the left an extra-axial thickening of the dura mater with enhancement and perilesional oedema, infiltrating the sphenoorbital fissure and an isointen…
Functional roles of the sweet taste receptor in oral and extraoral tissues
2014
International audience; Purpose of review: This review summarizes and discusses the current knowledge about the physiological roles of the sweet taste receptor in oral and extraoral tissues. Recent findings: The expression of a functional sweet taste receptor has been reported in numerous extragustatory tissues, including the gut, pancreas, bladder, brain and, more recently, bone and adipose tissues. In the gut, this receptor has been suggested to be involved in luminal glucose sensing, the release of some satiety hormones, the expression of glucose transporters, and the maintenance of glucose homeostasis. More recently, the sweet taste receptor was proposed to regulate adipogenesis and bon…
Laserfotokoagulation und photodynamische Therapie (PDT) zur Behandlung der retinalen angiomatösen Proliferation (RAP) bei feuchter altersabhängiger M…
2008
BACKGROUND: Retinal angiomatous proliferation (RAP) is a subtype of neovascular age-related macular degeneration (AMD) with particularly bad prognosis. Diverse treatment modalities are performed. PATIENTS AND METHODS: This is a retrospective review on the treatment results of 41 consecutive patients from 1 / 2003 to 12 / 2005 with RAP stage 1 - 3 (Yannuzzi classification), who were treated with laser photocoagulation, photodynamic therapy (PDT) and intravitreal injection of triamcinolone acetonide (IVT). Follow-up was 12 months minimally. RESULTS: In RAP stage I complete closure of the vascular lesion in 14 / 22 eyes was achieved by 1.2 ± 0.5 sessions of laser photocoagulation (4 × combined…
Photodynamic Therapy in Subfoveal Choroidal Neovascularisation
2002
Summary The exudative form of age-related macular degeneration (AMD) is the leading cause of blindness among people over 50 years of age in the western world. In 2–10% of cases a subfoveal choroidal neovascularisation develops. Conventional laser treatment leads to an unspecific destruction of the CNV including adjacent retinal structures. In addition, significant and immediate vision loss occurs, particularly in cases with central, subfoveal localization of the CNV.Photodynamic therapy (PDT) employing photochemical activation of verteporfin as a photosensitizer induces selective occlusion of CNV with minimal damage to the neurosensory retina and does not impair visual acuity. It became ava…
Is It a Metastatic Disease: A Case Report and New Understanding of Rosai-Dorfman Disease?
2017
Evolving European guidance on the medical management of neovascular age related macular degeneration
2006
BACKGROUND: Until recently, only two options were available for the treatment of choroidal neovascularisation (CNV) associated with age related macular degeneration (AMD)-thermal laser photocoagulation and photodynamic therapy with verteporfin (PDT-V). However, new treatments for CNV are in development, and data from phase III clinical trials of some of these pharmacological interventions are now available. In light of these new data, expert guidance is required to enable retina specialists with expertise in the management of AMD to select and use the most appropriate therapies for the treatment of neovascular AMD. METHODS: Consensus from a round table of European retina specialists was obt…
El tesoro medieval de la Catedral de Valencia
2020
Esta tesis doctoral se ha centrado en la investigación del tesoro medieval de la Catedral de Valencia con el objetivo principal de actualizar todo aquello que se había dicho sobre su origen y formación, e intentar dar un paso más, estableciendo un nuevo enfoque con el que tratar de explicar este tipo de piezas de gran valor histórico y artístico. Con esto hemos querido dejar patente la importancia del periodo medieval en la formación y posterior desarrollo del tesoro, en consonancia con el auge que experimentó la ciudad entre los siglos XIII y XVI. Para ello en un primer momento se ha comprobado que los estudios que iniciaron este interés, como los de José Sanchis Sivera y Peregrín Llorens …
Kadmiumaltistuksen havaitseminen Hydropsyche pellucidula -vesiperhostoukilla (Trichoptera: Hydropsychidae) hyperspektrikuvantamisen ja kidusvaurioide…
2017
Metallipäästöt aiheuttavat vesistöissä eliöyhteisöille monenlaisia haittavaikutuksia, joita voidaan tutkia bioindikaattori- eli ilmentäjälajimenetelmin. Vesiperhostoukkia (Trichoptera) on käytetty virtavesien metallisaastumisen indikaattoreina, sillä ne kestävät metallialtistusta suhteellisen hyvin, mutta altistuksen seurauksena toukilla voi esiintyä morfologisia muutoksia, kuten kidusvaurioita tai pintakudoksen tummumista. Koska toisaalta vierasaineiden kudospitoisuusmittaus on usein työlästä ja toisaalta rakenteellisten muutosten arviointi altis subjektiiviselle harhalle, tavoitteenani oli kehittää objektiivinen ja kustannustehokas tapa selvittää metallialtistusta ja sen vaikutuksia pohja…