Search results for "osta"
showing 10 items of 3709 documents
Partial Stabilization of Input-Output Contact Systems on a Legendre Submanifold
2017
This technical note addresses the structure preserving stabilization by output feedback of conservative input-output contact systems, a class of input-output Hamiltonian systems defined on contact manifolds. In the first instance, achievable contact forms in closed-loop and the associated Legendre submanifolds are analysed. In the second instance the stability properties of a hyperbolic equilibrium point of a strict contact vector field are analysed and it is shown that the stable and unstable manifolds are Legendre submanifolds. In the third instance the consequences for the design of stable structure preserving output feedback are derived: in closed-loop one may achieve stability only rel…
Tutorial on dynamic analysis of the Costas loop
2016
Abstract Costas loop is a classical phase-locked loop (PLL) based circuit for carrier recovery and signal demodulation. The PLL is an automatic control system that adjusts the phase of a local signal to match the phase of the input reference signal. This tutorial is devoted to the dynamic analysis of the Costas loop. In particular the acquisition process is analyzed. Acquisition is most conveniently described by a number of frequency and time parameters such as lock-in range, lock-in time, pull-in range, pull-in time, and hold-in range. While for the classical PLL equations all these parameters have been derived (many of them are approximations, some even crude approximations), this has not…
A methodology for evaluating the flexibility potential of domestic air-conditioning systems
2020
The paper presents a methodology for quantifying the electrical flexibility potential of air-conditioning systems (ACS) installed in residential buildings according to the building envelope characteristics and the ACS performance. In order to provide a thorough analysis of the issue, the ACS baseline consumption referred to the indoor temperature of 24°C has been computed for three typical residential buildings built in the South of Italy over different periods. The baseline consumption was used as a reference to estimate the effect of the set point temperature change on the ACS power profile. The results showed that increasing the set-point temperature of ACS by 2°C and 4°C leads to a redu…
Performance Improvement of a Hydraulic Active/Passive Heave Compensation Winch Using Semi Secondary Motor Control: Experimental and Numerical Verific…
2020
In this paper, a newly developed controller for active heave compensated offshore cranes is compared with state-of-the-art control methods. The comparison is divided into a numerical part on stability margins as well as operational windows and an experimental validation of the expected performance improvement based on a full-scale testing on site with a crane rated to 250 metric tons. Such a crane represents the typical target for the new control method using a combination of active and passive hydraulic actuation on the main winch. The active hydraulic actuation is a hydrostatic transmission with variable-displacement pumps and variable-displacement motors. The new controller employs feedf…
HACIA LA SOBERANIA ALIMENTARIA, ENTRE LA REORGANIZACION INSTITUCIONAL Y LA INICIATIVA LOCAL. EL PROYECTO COMUNITARIO DE RIEGO DE MARIANO ACOSTA (ECUA…
2018
Ecuador es una de las primeras naciones que ha incorporado en su texto constitucional el concepto de soberanía alimentaria. En su Carta Magna de 2008, el artículo 281 señala que la soberanía alimentaria constituye un objetivo estratégico y una obligación, y el artículo 282 requiere que el Estado prohíba el acaparamiento o la privatización del agua. En este contexto, la gestión y la regulación de los recursos hídricos han generado divergencias entre las autoridades centrales y las comunidades rurales. La aprobación de la Ley de Aguas de 2014 ha avivado estas discrepancias. A través del análisis del proyecto comunitario de Mariano Acosta en la provincia de Imbabura, este artículo cuestiona si…
Reaktion der Endothelzellen auf kurzzeitig physiologisch erhöhte hydrostatische Drücke und oxidativen Stress in vitro
2018
Zusammenfassung Hintergrund Im Rahmen der Pathogenese des Glaukoms wird die endotheliale Dysfunktion zunehmend diskutiert. Peripapilläre Blutungen sind diagnostisch wegweisend. Die Korrelation von Glaukomerkrankungen mit vaskulärem Dysregulationssyndrom ist eindeutig. Ziel dieser Studie ist es, die genaue Reaktion der Endothelzellen auf erhöhten hydrostatischen und oxidativen Stress zu untersuchen. Material und Methoden In vitro wurden primär dissoziierte BMECs (brain microvascular endothelial cells) für 3 Tage normalem und leicht erhöhtem hydrostatischem Druck von 60 und 120 mmHg in einer Druckkammer ausgesetzt. Zusätzlich wurden sowohl druckbelastete als auch nicht druckbelastete Zellen o…
Recombinant factor VIII: past, present and future of treatment of hemophilia A.
2018
The development of recombinant factor VIII (rFVIII) was initially driven by the necessity to treat hemophilia A (HA) patients with FVIII concentrates without the risk of transmitting infectious agents. Over the last three decades the safety of rFVIII has been further improved by completely removing animal or human proteins from the manufacturing process, so that patients would not be exposed to known or emerging pathogens. Recent efforts have concentrated on improving the expression of rFVIII, reducing its immunogenicity and enhancing its pharmacokinetic (PK) behavior. These new goals have been possible thanks to the develop-ment of biotechnology and a better knowledge of the function and s…
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment
2018
Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, s…
Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative ca…
2016
AbstractDoxorubicin is a widely used and effective chemotherapy drug. However, cardiac and skeletal muscle toxicity of doxorubicin limits its use. Inhibiting myostatin/activin signalling can prevent muscle atrophy, but its effects in chemotherapy-induced muscle wasting are unknown. In the present study we investigated the effects of doxorubicin administration alone or combined with activin receptor ligand pathway blockade by soluble activin receptor IIB (sACVR2B-Fc). Doxorubicin administration decreased body mass, muscle size and bone mineral density/content in mice. However, these effects were prevented by sACVR2B-Fc administration. Unlike in many other wasting situations, doxorubicin indu…