Search results for "otos"
showing 10 items of 857 documents
Aptiekā pieejamie bezrecepšu medikamenti un uztura bagātinātāji, kas var radīt dopinga efektu
2018
Mūsdienās ļoti aktuāla ir dopinga lietošanas problēma. Uzsvars tiek likts ne tikai uz negodīgu panākumu gūšanu, bet arī poteciālo blakusparādību risku, kas rada draudus sportista veselībai un dzīvībai. Darba mērķis ir iepazīties ar sportā aizliegto vielu un metožu sarakstu, izpētīt aptiekā pieejamo bezrecepšu medikamentu un uztura bagātinātāju sortimentu, terapeitisko devu ietekmi uz dopinga efektu, izzināt speciālistu un sportistu ieinteresētību dopinga lietošanā. Darba ietvaros tika veikta 59 farmācijas speciālistu anketēšana ar mērķi noskaidrot to zināšanas par dopingu saturošiem medikamentiem un ieinteresētību sportistu atbilstošā konsultēšanā. Pētījumā piedalījās arī 10 profesionāli mo…
Purification of Nano-Porous Silicon for Biomedical Applications
2011
Recently, various bio-medical applications of nanoporous silicon (np-Si) have been suggested. This work investigates the biocompatibility of np-Si particles taking into account hazardous residua confined in the pores after preparation. The emphasis is on the potential application of such particles as oxygen photosensitizer for photodynamic therapy of cancer, which requires both negligible toxicity of np-Si particles in darkness and a high photo-cyto-toxic effect due to generation of singlet oxygen under illumination. Considerable amounts of water soluble toxic impurities are found to be present in the nanoporous shell of micrometer-sized np-Si particles immediately after their preparation b…
Diurnal Cycle Relationships between Passive Fluorescence, PRI and NPQ of Vegetation in a Controlled Stress Experiment
2017
In order to estimate vegetation photosynthesis from remote sensing observations; some critical parameters need to be quantified. From all absorbed light; the plant needs to release any excess that is not used for photosynthesis; by non-photochemical quenching; by fluorescence emission and unregulated thermal dissipation. Non-photochemical quenching (NPQ) processes are controlled photoprotective mechanisms which; once activated; strongly control the dynamics of photochemical efficiency. With illumination conditions increasing and decreasing during a diurnal cycle; photoprotection mechanisms needs to change accordingly. The goal of this work is to quantify dynamic NPQ; measured from active fl…
De novo Transcriptome Assembly and Comparison of C3, C3-C4, and C4 Species of Tribe Salsoleae (Chenopodiaceae)
2017
C4 photosynthesis is a carbon-concentrating mechanism that evolved independently more than 60 times in a wide range of angiosperm lineages. Among other alterations, the evolution of C4 from ancestral C3 photosynthesis requires changes in the expression of a vast number of genes. Differential gene expression analyses between closely related C3 and C4 species have significantly increased our understanding of C4 functioning and evolution. In Chenopodiaceae, a family that is rich in C4 origins and photosynthetic types, the anatomy, physiology and phylogeny of C4, C2, and C3 species of Salsoleae has been studied in great detail, which facilitated the choice of six samples of five representative …
De novo Transcriptome Assembly and Comparison of C3, C3-C4, and C4 Species of Tribe Salsoleae (Chenopodiaceae)
2017
C4 photosynthesis is a carbon-concentrating mechanism that evolved independently more than 60 times in a wide range of angiosperm lineages. Among other alterations, the evolution of C4 from ancestral C3 photosynthesis requires changes in the expression of a vast number of genes. Differential gene expression analyses between closely related C3 and C4 species have significantly increased our understanding of C4 functioning and evolution. In Chenopodiaceae, a family that is rich in C4 origins and photosynthetic types, the anatomy, physiology and phylogeny of C4, C2, and C3 species of Salsoleae has been studied in great detail, which facilitated the choice of six samples of five representative …
Modulation of Efficient Diiodo-BODIPY in vitro Phototoxicity to Cancer Cells by Carbon Nano-Onions
2020
Photodynamic therapy (PDT) is currently one of the most promising approaches for targeted cancer treatment. It is based on responses of vital physiological signals, namely reactive oxygen species (ROS), which are associated with diseased condition development, such as tumors. This study presents the synthesis, incorporation, and application of a diiodo-BODIPY based photosensitizer, based on a non-covalent functionalization of carbon nano-onions (CNOs). In vitro assays demonstrate that HeLa cells internalize the diiodo-BODIPY molecules, and their CNOs nanohybrids. Upon cell internalization and light exposure, the pyrene-diiodo-BODIPY molecules induce an increase of the ROS level of HeLa cell…
Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
2021
Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…
Terahertz Absorption change in Photosynthetic Reaction Center upon photoactivation
2012
Photosynthetic reaction center is a membrane protein which plays an important role in converting solar energy into chemical energy. Upon continuous illumination a charge separation occurs within the protein which is stable for several seconds [1]. The stability of this state is very important to protect the protein against the release of excess heat and an instable radical due to charge recombination. Absorption of terahertz radiation corresponds to the excitation of large vibrations in the protein and is thus suitable for studying its different dynamical states. Here we recorded terahertz absorption spectra of the dark and illuminated state of reaction centre from the purple membrane bacte…
The effect of wood ash application on growth, leaf morphological and physiological traits of trees planted in a cutaway peatland
2021
Management of cutaway peatlands is a key issue in many countries. Whilst afforestation has been considered as a suitable after use option for cutaway peatlands, growing conditions after peat harvest are often adverse. To increase soil fertility and neutralise soil acidity, wood ash, an energy production by-product, can be used. In this study, we examined whether wood ash fertiliser affects growth (survival, height, root collar diameter), leaf morphological (mass, specific leaf area, leaf water content) and physiological traits (chlorophyll concentration, fluorescence parameters, photosynthetic and transpiration rate) of planted deciduous trees in a cutaway peatland in the central part of La…
Physiological and Structural Responses to Prolonged Water Deficit in Young Trees of Two Olive Cultivars
2022
This study aimed to characterize the physiological and structural responses of potted one-year-old olive trees belonging to two olive cultivars—‘Nocellara del Belice’ and ‘Cerasuola’—exposed to prolonged drought under greenhouse conditions. Two irrigation treatments based on evapotranspiration (ET) were imposed for 69 days, i.e., well-watered (WW, 100% ET) and drought-stressed (DS, 10–30% ET). Leaf stomatal conductance (gs), stem water potential (Ψstem), transpiration (E), photosynthetic capacity (Amax), water use efficiency (WUE), stem (Kstem) and root (Kroot) hydraulic conductance, trunk diameter variations (TDV), and leaf patch attenuated pre…