Search results for "ovarian reserve"
showing 4 items of 14 documents
The effect of cancer treatment on female fertility and strategies for preserving fertility.
2006
Aggressive chemotherapy and radiotherapy in young patients with cancer has greatly enhanced the life expectancy of these patients, but these treatments often cause infertility because of the massive destruction of the ovarian reserve resulting in premature ovarian failure (POF). This review focuses on the effect of cancer treatments on fertility and on the various surgical and assisted-reproduction innovations that are available to provide the patient with the option of future pregnancies. As the emerging discipline of fertility preservation is steadily attracting increasing interest, developments in the near future promise to be very exciting. However, in everyday routine work, better inte…
Reproduction beyond cancer: A message of hope for young women
2006
Abstract Objective. Aggressive chemotherapy and radiotherapy or radical oncological surgery in young women with cancer has greatly enhanced these patients' life expectancy, but these treatments often cause infertility or premature ovarian failure due to a massive destruction of the ovarian reserve. The objective of this review is to discuss the effect of the various cancer treatments on fertility and present the various fertility sparing operations and fertility preservation strategies. Method. An extensive survey of the most up-to-date literature was performed. Results. This review discusses the impact of current cancer treatment on fertility potential and the various surgical and assisted…
Stem cell-secreted factor therapy regenerates the ovarian niche and rescues follicles.
2021
Background Ovarian senescence is a normal age-associated phenomenon, but increasingly younger women are affected by diminished ovarian reserves or premature ovarian insufficiency. There is an urgent need for developing therapies to improve ovarian function in these patients. In this context, previous studies suggest that stem cell–secreted factors could have regenerative properties in the ovaries. Objective This study aimed to test the ability of various human plasma sources, enriched in stem cell–secreted factors, and the mechanisms behind their regenerative properties, to repair ovarian damage and to promote follicular development. Study Design In the first phase, the effects of human pla…
LH administration as a potential strategy for ovarian protection and female fertility preservation against highly gonadotoxic chemotherapy
2022
Els ovaris contenen una reserva de fol·licles no renovable, que produeixen un únic ovòcit fecundable a cada cicle menstrual al llarg de l'etapa reproductiva femenina (15-49 anys), però que disminueix progressivament amb l'edat. Per tant, els factors que afecten negativament la dotació de fol·licles provocaran una reducció significativa de la vida reproductiva en la dona. Les teràpies oncològiques basades en l'administració de quimioteràpia alquilant s'utilitzen habitualment per a tractar els càncers ginecològics en pacients joves, però amb freqüència acceleren l'esgotament de la reserva fol·licular i l'aparició de la menopausa. Els efectes secundaris de la quimioteràpia sobre la fertilitat,…