Search results for "ovarian"
showing 10 items of 785 documents
An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
2020
Abstract The organometallic AuI bis‐N‐heterocyclic carbene complex [Au(9‐methylcaffeine‐8‐ylidene)2]+ (AuTMX2) was previously shown to selectively and potently stabilise telomeric DNA G‐quadruplex (G4) structures. This study sheds light on the molecular reactivity and mode of action of AuTMX2 in the cellular context using mass spectrometry‐based methods, including shotgun proteomics in A2780 ovarian cancer cells. In contrast to other metal‐based anticancer agents, this organogold compound is less prone to form coordinative bonds with biological nucleophiles and is expected to exert its drug effects mainly by non‐covalent interactions. Global protein expression changes of treated cancer cell…
Statistical properties of the site-frequency spectrum associated with lambda-coalescents.
2013
Abstract Statistical properties of the site-frequency spectrum associated with Λ-coalescents are our objects of study. In particular, we derive recursions for the expected value, variance, and covariance of the spectrum, extending earlier results of Fu (1995) for the classical Kingman coalescent. Estimating coalescent parameters introduced by certain Λ-coalescents for data sets too large for full-likelihood methods is our focus. The recursions for the expected values we obtain can be used to find the parameter values that give the best fit to the observed frequency spectrum. The expected values are also used to approximate the probability a (derived) mutation arises on a branch subtending a…
Boundary quotients and ideals of Toeplitz C∗-algebras of Artin groups
2006
We study the quotients of the Toeplitz C*-algebra of a quasi-lattice ordered group (G,P), which we view as crossed products by a partial actions of G on closed invariant subsets of a totally disconnected compact Hausdorff space, the Nica spectrum of (G,P). Our original motivation and our main examples are drawn from right-angled Artin groups, but many of our results are valid for more general quasi-lattice ordered groups. We show that the Nica spectrum has a unique minimal closed invariant subset, which we call the boundary spectrum, and we define the boundary quotient to be the crossed product of the corresponding restricted partial action. The main technical tools used are the results of …
A Quasilinear Parabolic Equation with Quadratic Growth of the Gradient modeling Incomplete Financial Markets
2004
We consider a quasilinear parabolic equation with quadratic gradient terms. It arises in the modeling of an optimal portfolio which maximizes the expected utility from terminal wealth in incomplete markets consisting of risky assets and non-tradable state variables. The existence of solutions is shown by extending the monotonicity method of Frehse. Furthermore, we prove the uniqueness of weak solutions under a smallness condition on the derivatives of the covariance matrices with respect to the solution. The in influence of the non-tradable state variables on the optimal value function is illustrated by a numerical example.
Recovering Quantum Properties of Continuous-Variable States in the Presence of Measurement Errors.
2016
We present two results which combined enable one to reliably detect multimode, multipartite entanglement in the presence of measurement errors. The first result leads to a method to compute the best (approximated) physical covariance matrix given a measured non-physical one. The other result states that a widely used entanglement condition is a consequence of negativity of partial transposition. Our approach can quickly verify entanglement of experimentally obtained multipartite states, which is demonstrated on several realistic examples. Compared to existing detection schemes, ours is very simple and efficient. In particular, it does not require any complicated optimizations.
SU(3)-breaking corrections to the hyperon vector couplingf1(0)in covariant baryon chiral perturbation theory
2009
This work was partially supported by the MEC Grant No. FIS2006-03438 and the European Community- Research Infrastructure Integrating Activity Study of Strongly Interacting Matter (Hadron-Physics2, Grant Agreement 227431) under the Seventh Framework Programme of EU. L. S. G. acknowledges support from the MICINN in the Program ‘‘Juan de la Cierva.’’ J. M. C. acknowledges the same institution for an FPU grant.
Nucleon Structure Functions and Light-Front Dynamics
1999
We present a quark-parton model to describe polarized and unpolarized nucleon structure functions. The twist-two matrix elements for the QCD evolution analysis of lepton-hadron scattering are calculated within a light-front covariant quark model. The relativistic effects in the three-body wave function are discussed for both the polarized and unpolarized cases. Predictions are given for the polarized gluon distributions as will be seen in future experiments.
THE OPERATOR PRODUCT EXPANSION OF THE QCD PROPAGATORS
1992
We bring together for the first time the coefficients in covariant gauges of all the condensates of dimension four or less in the operator product expansion (OPE) of the quark, gluon and ghost propagators. It is stressed that contrary to general belief the condensates do not enter the OPE of the propagators in gauge-invariant combinations like [Formula: see text] and 〈G2〉. The results are presented in arbitrary dimension to lowest order in the light quark masses for the SU (Nc) internal symmetry group. All terms which, through the equations of motion, may be viewed as being effectively of order αs are included. The importance of the equations of motion if one is to fulfill the Slavnov-Tayl…
Non-Markovianity of Gaussian Channels
2015
We introduce a necessary and sufficient criterion for the non-Markovianity of Gaussian quantum dynamical maps based on the violation of divisibility. The criterion is derived by defining a general vectorial representation of the covariance matrix which is then exploited to determine the condition for the complete positivity of partial maps associated to arbitrary time intervals. Such construction does not rely on the Choi-Jamiolkowski representation and does not require optimization over states.
Electromagnetic structure of few-nucleon ground states
2015
Experimental form factors of the hydrogen and helium isotopes, extracted from an up-to-date global analysis of cross sections and polarization observables measured in elastic electron scattering from these systems, are compared to predictions obtained in three different theoretical approaches: the first is based on realistic interactions and currents, including relativistic corrections (labeled as the conventional approach); the second relies on a chiral effective field theory description of the strong and electromagnetic interactions in nuclei (labeled $\chi$EFT); the third utilizes a fully relativistic treatment of nuclear dynamics as implemented in the covariant spectator theory (labeled…