Search results for "ovarian"
showing 10 items of 785 documents
Separation of Uncorrelated Stationary time series using Autocovariance Matrices
2015
Blind source separation (BSS) is a signal processing tool, which is widely used in various fields. Examples include biomedical signal separation, brain imaging and economic time series applications. In BSS, one assumes that the observed $p$ time series are linear combinations of $p$ latent uncorrelated weakly stationary time series. The aim is then to find an estimate for an unmixing matrix, which transforms the observed time series back to uncorrelated latent time series. In SOBI (Second Order Blind Identification) joint diagonalization of the covariance matrix and autocovariance matrices with several lags is used to estimate the unmixing matrix. The rows of an unmixing matrix can be deriv…
The Induced Smoothed lasso: A practical framework for hypothesis testing in high dimensional regression.
2020
This paper focuses on hypothesis testing in lasso regression, when one is interested in judging statistical significance for the regression coefficients in the regression equation involving a lot of covariates. To get reliable p-values, we propose a new lasso-type estimator relying on the idea of induced smoothing which allows to obtain appropriate covariance matrix and Wald statistic relatively easily. Some simulation experiments reveal that our approach exhibits good performance when contrasted with the recent inferential tools in the lasso framework. Two real data analyses are presented to illustrate the proposed framework in practice.
Tests and estimates of shape based on spatial signs and ranks
2009
Nonparametric procedures for testing and estimation of the shape matrix in the case of multivariate elliptic distribution are considered. Testing for sphericity is an important special case. The tests and estimates are based on the spatial sign and rank covariance matrices. The estimates based on the spatial sign covariance matrix and symmetrized spatial sign covariance matrix are Tyler's [A distribution-free M-estimator of multivariate scatter, Ann. Statist. 15 (1987), pp. 234–251] shape matrix and and Dümbgen's [On Tyler's M-functional of scatter in high dimension, Ann. Inst. Statist. Math. 50 (1998), pp. 471–491] shape matrix, respectively. The test based on the spatial sign covariance m…
On the stability and ergodicity of adaptive scaling Metropolis algorithms
2011
The stability and ergodicity properties of two adaptive random walk Metropolis algorithms are considered. The both algorithms adjust the scaling of the proposal distribution continuously based on the observed acceptance probability. Unlike the previously proposed forms of the algorithms, the adapted scaling parameter is not constrained within a predefined compact interval. The first algorithm is based on scale adaptation only, while the second one incorporates also covariance adaptation. A strong law of large numbers is shown to hold assuming that the target density is smooth enough and has either compact support or super-exponentially decaying tails.
A Random Field Approach to Transect Counts of Wildlife Populations
1991
Line transect counting of a wildlife population is considered a sampling from a planar marked point process, where the marks describe the detectability of the animals. Sampling properties of transect counts and a new density estimator are derived from a counting process, which is a shot-noise field induced by the marked point process. A general formula for the sampling variance of a transect is derived and applied to compare five common types of transects. Some stereological connections of transect sampling and density estimators are shown.
Firm Size and Volatility Analysis in the Spanish Stock Market
2011
In this article, three strongly related questions are studied. First, volatility spillovers between large and small firms in the Spanish stock market are analyzed by using a conditional CAPM with an asymmetric multivariate GARCH-M covariance structure. Results show that there exist bidirectional volatility spillovers between both types of firms, especially after bad news. Second, the volatility feedback hypothesis explaining the volatility asymmetry feature is investigated. Results show significant evidence for this hypothesis. Finally, the study uncovers that conditional beta coefficient estimates within the used model are insensitive to sign and size asymmetries in the unexpected shock re…
Feasibility of an induced metabolic bioluminescence imaging technique in ovarian cancer: Results of a pilot study.
2016
e17093Background: The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural comple...
Spacelike energy of timelike unit vector fields on a Lorentzian manifold
2004
On a Lorentzian manifold, we define a new functional on the space of unit timelike vector fields given by the L2 norm of the restriction of the covariant derivative of the vector field to its orthogonal complement. This spacelike energy is related with the energy of the vector field as a map on the tangent bundle endowed with the Kaluza–Klein metric, but it is more adapted to the situation. We compute the first and second variation of the functional and we exhibit several examples of critical points on cosmological models as generalized Robertson–Walker spaces and Godel universe, on Einstein and contact manifolds and on Lorentzian Berger’s spheres. For these critical points we have also stu…
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
2013
Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…
Generalized Virasoro anomaly and stress tensor for dilaton coupled theories
2003
We derive the anomalous transformation law of the quantum stress tensor for a 2D massless scalar field coupled to an external dilaton. This provides a generalization of the Virasoro anomaly which turns out to be consistent with the trace anomaly. We apply it together with the equivalence principle to compute the expectation values of the covariant quantum stress tensor on a curved background. Finally we briefly illustrate how to evaluate vacuum polarization and Hawking radiation effects from these results.