Search results for "ovarian"
showing 10 items of 785 documents
Biocompatible Lipid Nanoparticles as Carriers to Improve Curcumin Efficacy in Ovarian Cancer Treatment
2017
Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumoral activity of curcumin, by entrapping it into nanostructured lipid carriers (NLCs). For this purpose here we describe the preparation and characterization of three kinds of curcumin-loaded NLCs. The nanosystems allowed the achievement of a controlled release of curcumin, the amounts of curcumin r…
Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850)
2020
ObjectiveTo investigate whether neoadjuvant chemotherapy followed by interval debulking surgery is superior to primary debulking surgery in terms of perioperative complications and progression-free survival, in advanced epithelial ovarian, fallopian tube or primary peritoneal cancer patients with high tumor load.MethodsPatients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer (stage IIIC-IV) underwent laparoscopy. Patients with high tumor load assessed by a standardized laparoscopic predictive index were randomly assigned (1:1 ratio) to undergo either primary debulking surgery followed by adjuvant chemotherapy (arm A), or neoadjuvant chemotherapy followed by int…
Rescue of ovarian function: stem cells and regenerative factors
2022
El envejecimiento y otras condiciones de daño adquiridas, como los tratamientos oncológicos, conducen a un deterioro de la función ovárica. Sin embargo, incluso cuando los ovarios dañados pierden su capacidad de ovular, permanece un conjunto residual de folículos quiescentes que podrían ser rescatados y desarrollados en un nicho ovárico adecuado, dando lugar a ovocitos maduros. Los factores solubles secretados por las células madre podrían proporcionar un entorno ovárico adecuado para mantener y promover el crecimiento folicular. Por lo tanto, la presente tesis doctoral tuvo como objetivo evaluar los efectos regenerativos de diferentes fuentes de factores secretados por células madre en mod…
Clinical Significance of Tie-2-Expressing Monocytes/Macrophages and Angiopoietins in the Progression of Ovarian Cancer—State-of-the-Art
2022
Tumour growth and metastasis are specific to advanced stages of epithelial ovarian cancer (EOC). Tumour angiogenesis is an essential part of these processes. It is responsible for providing tumours with nutrients, metabolites, and cytokines and facilitates tumour and immune cell relocation. Destabilised vasculature, a distinctive feature of tumours, is also responsible for compromising drug delivery into the bulk. Angiogenesis is a complex process that largely depends on how the tumour microenvironment (TME) is composed and how a specific organ is formed. There are contrary reports on whether Tie-2-expressing monocytes/macrophages (TEMs) reported as the proangiogenic population of monocytes…
One-Trocar,viedo-assisted stripping technique for use in the treatment of large ovarian cysts in infants
2010
LH administration as a potential strategy for ovarian protection and female fertility preservation against highly gonadotoxic chemotherapy
2022
Els ovaris contenen una reserva de fol·licles no renovable, que produeixen un únic ovòcit fecundable a cada cicle menstrual al llarg de l'etapa reproductiva femenina (15-49 anys), però que disminueix progressivament amb l'edat. Per tant, els factors que afecten negativament la dotació de fol·licles provocaran una reducció significativa de la vida reproductiva en la dona. Les teràpies oncològiques basades en l'administració de quimioteràpia alquilant s'utilitzen habitualment per a tractar els càncers ginecològics en pacients joves, però amb freqüència acceleren l'esgotament de la reserva fol·licular i l'aparició de la menopausa. Els efectes secundaris de la quimioteràpia sobre la fertilitat,…
Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations
1999
Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) w…
Trasplante autólogo de médula ósea en ovario en mujeres con baja reserva ovárica y fallo ovárico precoz, para rejuvenecimiento del nicho ovárico y fa…
2020
Como consecuencia del retraso de la maternidad a causa de las tendencias sociales actuales, existe una disminución de la calidad y cantidad de ovocitos disponibles. Al problema fisiológico de la edad materna avanzada, se suman dos patologías, que asocian una baja reserva ovárica, en pacientes jóvenes: baja respuesta ovárica (del inglés, poor ovarian response, o POR), e insuficiencia ovárica prematura(del inglés, premature ovarian insufficiency o POI). Numerosos protocolos de estimulación ovárica han sido desarrollados, sin ser efectivos, siendo en la mayoría de los casos, la única opción para estas pacientes la donación de ovocitos/embriones. Varios trabajos de investigación han descrito la…
Prognostic and Predictive Role of Tumor-Infiltrating Lymphocytes (TILs) in Ovarian Cancer
2022
In the last decade, tumor-infiltrating lymphocytes (TILs) have been recognized as clinically relevant prognostic markers for improved survival, providing the immunological basis for the development of new therapeutic strategies and showing a significant prognostic and predictive role in several malignancies, including ovarian cancer (OC). In fact, many OCs show TILs whose typology and degree of infiltration have been shown to be strongly correlated with prognosis and survival. The OC histological subtype with the higher presence of TILs is the high-grade serous carcinoma (HGSC) followed by the endometrioid subtype, whereas mucinous and clear cell OCs seem to contain a lower percentage of TI…
Joint second-order parameter estimation for spatio-temporal log-Gaussian Cox processes
2018
We propose a new fitting method to estimate the set of second-order parameters for the class of homogeneous spatio-temporal log-Gaussian Cox point processes. With simulations, we show that the proposed minimum contrast procedure, based on the spatio-temporal pair correlation function, provides reliable estimates and we compare the results with the current available methods. Moreover, the proposed method can be used in the case of both separable and non-separable parametric specifications of the correlation function of the underlying Gaussian Random Field. We describe earthquake sequences comparing several Cox model specifications.