Search results for "overload"
showing 10 items of 105 documents
Artificial intelligence to counteract “KPI overload” in business process monitoring: the case of anti-corruption in public organizations
2023
PurposeThe nature and amount of data that public organizations have to monitor to counteract corruption lead to a phenomenon called “KPI overload”, consisting of the business analyst feeling overwhelmed by the amount of information and resulting in the absence of appropriate control. The purpose of this study is to develop a solution based on Artificial Intelligence technology to avoid data overloading and, at the same time, under-controlling in business process monitoring.Design/methodology/approachThe authors adopted a design science research approach. The authors started by observing a specific problem in a real context (a healthcare organization); then conceptualized, designed and imple…
Burnout Syndrome in municipal health managers
2016
Resumo Introdução Os gestores municipais da saúde devem responder às demandas de suas equipes e dos pacientes do Sistema Único de Saúde, enfrentando cotidianamente situações potencialmente estressoras. A sobrecarga no trabalho pode levar à exaustão física e mental, com esgotamento dos recursos emocionais, e desencadear a Síndrome de Burnout (SB), cujas consequências podem atingir o serviço gerenciado, uma vez que, ao desempenhar essa atividade laboral, tomam-se decisões determinantes nas ações em saúde que afetam muitas pessoas. Este estudo verificou a presença da SB nos gestores municipais de saúde do Estado de São Paulo. Métodos Estudo do tipo transversal no qual foram coletados dados soc…
Nonlinear Analysis of Charge-Pump Phase-Locked Loop : The Hold-In and Pull-In Ranges
2021
In this paper a fairly complete mathematical model of CP-PLL, which reliable enough to serve as a tool for credible analysis of dynamical properties of these circuits, is studied. We refine relevant mathematical definitions of the hold-in and pull-in ranges related to the local and global stability. Stability analysis of the steady state for the charge-pump phase locked loop is non-trivial: straight-forward linearization of available CP-PLL models may lead to incorrect conclusions, because the system is not smooth near the steady state and may experience overload. In this work necessary details for local stability analysis are presented and the hold-in range is computed. An upper estimate o…
Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload
2012
AIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/-) mice, having a 50% reduction in OPA1 protein expression in cardiac tissue. METHODS AND RESULTS: In mutant mice, cardiac function assessed by echocardiography was not significantly different from that of the Opa1(+/+). Electron and fluorescence microscopy revealed altered morphology of the Opa1(+/-) mice mitochondrial network; unexpectedly, mitochondria were larger with the presence of clusters of fused mitochondria and altered c…
Procollagen C-Proteinase Enhancer 1 (PCPE-1) is a marker of myocardial fibrosis and impaired cardiac function in a murine model of pressure overload
2021
Abstract(1)AimsProcollagen C-proteinase enhancer 1 (PCPE-1) is an extracellular matrix protein and a major regulator of fibrillar collagen biosynthesis. Previous work has shown that its abundance is often increased in the context of tissue repair and fibrosis. The present study was designed to evaluate its potential as a biomarker of myocardial interstitial fibrosis (MIF), a well-established pathogenic pathway leading to heart failure.(2)Methods and ResultsCardiac fibrosis was induced in rats using an optimized model of chronic pressure overload triggered by angiotensin II and Nω-nitro-L-arginine methyl ester (L-NAME). All treated animals suffered from heart hypertrophy and the increase in …
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure
2008
AIMS: Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the control of cardiac gene expression. Specific histone deacetylases (HDACs) can, in fact, play a positive or negative role in determining cardiac myocyte (CM) size. Here, we report on the effect on hypertrophy development of three inhibitors (HDACi) of class I HDACs. METHODS AND RESULTS: The compounds were first analysed in vitro by scoring hypertrophy, expression of foetal genes, and apoptosis of neonatal rat CMs stimulated with phenylephrine, an alpha1-adrenergic agonist. This initial screening indicated that a truncated derivative of apicidin with class I HDAC specif…
L'effetto del sovraccarico di scelta: un'indagine su bambini, adolescenti, adulti e anziani
2021
L’effetto del sovraccarico di scelta è stato finora studiato prevalentemente su adulti. L’unico studio condotto su fasce di età diverse dagli adulti ha fornito una prima dimostrazione del fatto che le conseguenze negative dell’avere troppa scelta non si estendono in egual misura a bambini, adolescenti, adulti e anziani. Il presente lavoro si propone di indagare ulteriormente le conseguenze negative dell’avere troppa scelta su bambini, adolescenti e anziani. I dati suggeriscono che mentre gli adolescenti sono influenzati dal fenomeno in modo simile agli adulti, i bambini e gli anziani sembrano invece esserne immuni. Sono discusse le implicazioni teoriche e pratiche dei risultati e sono forni…
The Role of the Brand on Choice Overload
2019
Current research on choice overload has been mainly conducted with choice options not associated with specific brands. This study investigates whether the presence of brand names in the choice set affects the occurrence of choice overload. Across four studies, we find that when choosing among an overabundance of alternatives, participants express more positive feelings (i.e., higher satisfaction/confidence, lower regret and difficulty) when all the options of the choice set are associated with familiar brands, rather than unfamiliar brands or no brand at all. We also find that choice overload only appears in the absence of brand names, but disappears when all options contain brand names—eit…
Do too many choices have negative consequences? An empirical review
2013
Various experiments demonstrated that having too much choice has negative consequences on the motivation to choose and on the satisfaction with the chosen option. However, the literature reports conflicting results showing that choosing from large assortments has advantages. This paper reviews the main empirical results in favor and against the negative effect of too much choice and identifies possible directions for further research. Copyright © 2013 by Società editrice il Mulino.
La linea spezzata. Una ricostruzione critica dell'attuale deficit di coerenza
2021
Siamo nell’era della smemoratezza. Una smemoratezza prodotta dalla sovrabbondanza di informazioni, dalla pratica del multitasking, dalla propensione a demandare la conservazione dei ricordi ai device e ai cloud di cui facciamo uso ogni giorno. La fragilità della memoria ha spezzato la linea che congiungeva passato, presente e futuro, la linea che li attraversava e li rendeva coerenti. Ma lo ha fatto solo nella nostra testa, perché sul piano della realtà gli effetti delle scelte di ieri non smettono di presentarsi all’oggi. L’allargamento degli orizzonti culturali prodotto dalla globalizzazione ha ridotto tutti gli elementi del nostro panorama a dettagli lontani e indistinguibili. Ma lo ha f…