Search results for "oxadizole"

showing 3 items of 3 documents

Metal complexes of oxadiazole ligands: An overview

2019

Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.

OxadizoleAnti-Inflammatory AgentsOxadiazoleAntineoplastic AgentsReviewmetal complexes010402 general chemistryRing (chemistry)01 natural sciencesCatalysisInorganic ChemistryMetallcsh:ChemistryAntineoplastic Agentchemistry.chemical_compoundOrganometallic CompoundsPhysical and Theoretical ChemistryMolecular Biologylcsh:QH301-705.5SpectroscopyScientific disciplinesGroup 2 organometallic chemistryOrganometallic CompoundOxadiazoles010405 organic chemistryChemistryMetalOrganic ChemistryGeneral MedicineCombinatorial chemistry0104 chemical sciencesComputer Science ApplicationsAnti-Inflammatory Agent124-oxadizolelcsh:Biology (General)lcsh:QD1-999MetalsSettore CHIM/03 - Chimica Generale E Inorganicavisual_artvisual_art.visual_art_mediumMetal complexe134-oxadizole
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Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process.

2022

Objective Nonsense mutations are responsible for 15% of Cystic Fibrosis (CF) patients due to the introduction of a premature stop codon (PTC) in the mRNA and the production of a truncated CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein1. A promising therapeutic approach for stop mutations is the suppression therapy by Translational Readthrough Inducing Drugs (TRIDs) to restore the expression of the protein2,3. Recently three new TRIDS (NV848, NV914, NV930) have been proposed and validated by several assays. Our work was focused on TRIDs NV848, NV914, NV930. Important aspects of TRIDs to be evaluated are their specificity towards PTC, to demonstrate that TRIDs do not inter…

Settore BIO/18 - GeneticaSettore BIO/11 - Biologia MolecolareSettore CHIM/06 - Chimica OrganicaNonsense mutations genetic diseases oxadizole target therapy TRIDs.Settore CHIM/08 - Chimica Farmaceutica
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Crystal structure and Hirshfeld surface analysis of 1-(4-chloro­phen­yl)-2-{[5-(4-chloro­phen­yl)-1,3,4-oxa­diazol-2-yl]sulfan­yl}ethanone

2017

The title heterocyclic compound is contains an oxadizole and two chloro-substituted phenyl rings. In the crystal, C—H⋯N hydrogen bonding links the mol­ecules into undulating ribbons parallel to the b axis. Hirshfeld surface analysis indicates that the most important contributions for the crystal packing are the H⋯C (18%), H⋯H (17%), H⋯Cl (16.6%), H⋯O (10.4%), H⋯N (8.9%) and H⋯S (5.9%) inter­actions.

Surface (mathematics)crystal structureStereochemistryCrystal structureDihedral angle010403 inorganic & nuclear chemistryRing (chemistry)01 natural scienceschloro­phen­ylResearch Communicationslcsh:ChemistryCrystalchemistry.chemical_compoundchlorophenylHirshfeld surface analysisGeneral Materials ScienceBenzene010405 organic chemistryHydrogen bondGeneral ChemistryCondensed Matter Physicsoxadizole0104 chemical sciencesCrystallographylcsh:QD1-999chemistryX-ray structureActa Crystallographica Section E: Crystallographic Communications
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