Search results for "p-isothiocyanatobenzyl-desferrioxamine"

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89 Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89 Zr Radiochemistry

2017

Contains fulltext : 181624.pdf (Publisher’s version ) (Open Access) Immuno-positron emission tomography (immunoPET) with (89)Zr-labeled antibodies has shown great potential in cancer imaging. It can provide important information about the pharmacokinetics and tumor-targeting properties of monoclonal antibodies and may help in anticipating on toxicity. Furthermore, it allows accurate dose planning for individualized radioimmunotherapy and may aid in patient selection and early-response monitoring for targeted therapies. The most commonly used chelator for (89)Zr is desferrioxamine (DFO). Preclinical studies have shown that DFO is not an ideal chelator because the (89)Zr-DFO complex is partly…

Pathologymedicine.medical_specialtymedicine.drug_classmedicine.medical_treatmentmonoclonal-antibodiesBiomedical Engineeringrational designPharmaceutical Sciencebifunctional chelating-agentBioengineeringCancer imagingReviewgrowth-factorRare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]010402 general chemistryMonoclonal antibody01 natural sciencesDose planningp-isothiocyanatobenzyl-desferrioxamineIn vivo[ CHIM.ORGA ] Chemical Sciences/Organic chemistryimmuno-petmedicineIn patient[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyPharmacologymedicine.diagnostic_test010405 organic chemistrybusiness.industry[CHIM.ORGA]Chemical Sciences/Organic chemistryOrganic Chemistrydrug development3. Good health0104 chemical sciencesDrug developmentPositron emission tomographyRadioimmunotherapyUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]click chemistryCancer researchmetastatic breast-cancerbusinessbearing nude-miceNanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]BiotechnologyBioconjugate Chemistry
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Nb-90 - a potential PET nuclide: production and labeling of monoclonal antibodies

2012

Abstract Fast progressing immuno-PET gives reasons to develop new potential medium-long and long-lived radioisotopes. One of the promising candidates is 90Nb. It has a half-life of 14.6 h, which allows visualizing and quantifying processes with medium and slow kinetics, such as tumor accumulation of antibodies and antibodies fragments or polymers and other nanoparticles. 90Nb exhibits a high positron branching of 53% and an optimal energy of β + emission of E mean=0.35 MeV only. Consequently, efficient radionuclide production routes and NbV labeling techniques are required. 90Nb was produced by the 90Zr(p,n) 90Nb nuclear reaction on natural zirconium targets. No-carrier-added (n.c.a.) 90Nb …

business.industryChemistryRadiochemistryHead and neck surgeryP-isothiocyanatobenzyl-desferrioxamineUniversity medicalPhysical and Theoretical ChemistryNuclear medicinebusinessImmuno petRadiochimica acta
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