Search results for "pOR"
showing 10 items of 32221 documents
Prefazione
2013
Behavioral Activation through Virtual Reality for Depression: A Single Case Experimental Design with Multiple Baselines
2022
Behavioral activation (BA) is a structured psychotherapeutic approach for the treatment of major depressive disorder (MDD), which aims at increasing the engagement in activities that might bring enjoyment and meaning to patients’ lives. Although a growing body of evidence supports the effectiveness of BA, enhancing the motivation and activity level of depressed patients is often challenging. In the present study, we explored the effectiveness of a brief BA treatment supported by virtual reality (VR) to facilitate the visualization and anticipation of four pleasurable activities that we tried to re-introduce in the patients’ daily routine. To do so, we conducted a single-case experimental de…
Sport Ethics: The substantialist proposal of Lumpkin, Stoll and Beller, from ethical proceduralism
2013
En este artículo presento de forma crítica la propuesta de ética del deporte como «bolsa de virtudes» que elaboran tres autores estadounidenses que son Lumpkin, Stoll y Beller. Dicha propuesta debe entenderse como una manifestación de sustancialismo neoaristotélico en deporte, con una clara influencia de MacIntyre. Mi objetivo es mostrar cómo dicho sustancialismo no es suficiente para una propuesta ética del deporte, por lo que abogo por incorporar algunos de los presupuestos del procedimentalismo ético aplicado al deporte. In this article the author presents critically the proposed sports ethics as «bag of virtues» that Americans made three authors are Lumpkin, Stoll and Beller. This propo…
El Instituto Médico Valenciano y la difusión de la vacuna antivariólica
2006
L'Institut Mèdic Valencià va ser l'impulsor d'una campanya de vacunació antivariòlica gratuïta en la segona meitat del segle XIX mitjançant vacuna humanitzada remesa des d'Anglaterra. Va difondre la vacuna per tota Espanya i va publicar unes acurades estadístiques de les vacunacions practicades en el Boletín del Instituto Médico Valenciano. // . El Instituto Médico Valenciano fue el impulsor de una campaña de vacunación antivariólica gratuita en la segunda mitad del siglo XIX mediante vacuna humanizada remitida desde Inglaterra. Difundió la vacuna por toda España y publicó unas cuidadosas estadísticas de las vacunaciones practicadas en el Boletín del Instituto Médico Valenciano.
La producción y difusión de las vacunas en España. La vacuna antivariólica (1899-1982)
2015
S'estudia la producció i difusió de les vacunes a Espanya, en concret, la antivariolosa en el període 1899-1982. Des de 1899 i durant les dues primeres dècades del segle XX, la vacuna antivariolosa era produïda en laboratoris bacteriològics. Posteriorment, les investigacions de l'Institut Nacional d'Higiene de Madrid i del Centre Nacional de Virologia van ser determinants, per a la fabricació de la vacuna contra la variola. Van destacar les figures d'Eduardo Gallardo Martínez i Florencio Pérez Gallardo. //. Se estudia la producción y difusión de las vacunas en España, en concreto, la antivariólica en el periodo 1899-1982. Desde 1899 y durante las dos primeras décadas del siglo XX, la vacuna…
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
2021
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…
Peptide-mediated interference with baculovirus transduction
2007
Baculovirus represents a multifunctional platform with potential for biomedical applications including disease therapies. The importance of F3, a tumor-homing peptide, in baculovirus transduction was previously recognized by the ability of F3 to augment viral binding and gene delivery to human cancer cells following display on the viral envelope. Here, F3 was utilized as a molecular tool to expand understanding of the poorly characterized baculovirus-mammalian cell interactions. Baculovirus-mediated transduction of HepG2 hepatocarcinoma cells was strongly inhibited by coincubating the virus with synthetic F3 or following incorporation of F3 into viral nucleocapsid by genetic engineering, th…
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …
Genomic structure and promoter analysis of pathogen-inducedrepatgenes fromSpodoptera exigua
2009
The repat gene family encodes midgut proteins overexpressed in response to pathogen infection in the lepidopteran Spodoptera exigua. Up-regulation of repat genes has been observed after challenging the larvae with both Bacillus thuringiensis toxins and after infection with the baculovirus Autographa californica multiple nucleopolyhedrovirus. In our study, PCR amplification of the genomic region and genome walking were used to obtain the genomic structure and the sequence of the 5'-upstream region of repat1 and repat2, two of the most phylogenetically distant members of the repat family. A similar gene structure between repat1 and repat2 has been found, with conserved exon-intron positions a…
Assembly and Translocation of Papillomavirus Capsid Proteins
2002
ABSTRACT The major and minor capsid proteins of polyomavirus are preassembled in the cytoplasm and translocated to the nucleus only as a VP1-VP2/VP3 complex. In this study, we describe independent nuclear translocation of the L1 major protein and the L2 minor capsid protein of human papillomavirus type 33 by several approaches. First, we observed that expression and nuclear translocation of L2 in natural lesions precede expression of L1. Second, using a cell culture system for coexpression, we found that accumulation of L2 in nuclear domain 10 (ND10) subnuclear structures precedes L1 by several hours. In contrast, complexes of L2 and mutants of L1 forced to assemble in the cytoplasm are tra…