Search results for "pPb"
showing 10 items of 65 documents
Molecular characterization of congenital myasthenic syndromes in Spain.
2017
Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders, all of which impair neuromuscular transmission. Epidemiological data and frequencies of gene mutations are scarce in the literature. Here we describe the molecular genetic and clinical findings of sixty-four genetically confirmed CMS patients from Spain. Thirty-six mutations in the CHRNE, RAPSN, COLQ, GFPT1, DOK7, CHRNG, GMPPB, CHAT, CHRNA1, and CHRNB1 genes were identified in our patients, with five of them not reported so far.. These data provide an overview on the relative frequencies of the different CMS subtypes in a large Spanish population. CHRNE mutations are the most common cause of CMS in Spain, …
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
2021
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify novel senolytics. We discovered the nociceptin receptor FQ opioid receptor (NOP) selective ligand 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole (MCOPPB, a compound previously studied as potential anxiolytic) as the best scoring hit. The ability of MCOPPB to eliminate senescent cells in in vitro models was further tested…
"Table 41" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $y*$ extracted from the invariant yields for eight $p_{T}$ ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 45" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $y*$ extracted from the invariant yields for eight $p_{T}$ ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 34" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $p_{T}$ extracted from the invariant yields for six rapidity ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 13" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $p_{T}$ extracted from the invariant yields for six rapidity ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 24" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $p_{T}$ extracted from the invariant yields for six rapidity ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 44" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $y*$ extracted from the invariant yields for eight $p_{T}$ ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 43" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $y*$ extracted from the invariant yields for eight $p_{T}$ ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.
"Table 20" of "Transverse momentum, rapidity, and centrality dependence of inclusive charged-particle production in $\sqrt{s_{NN}}=5.02$ TeV p+Pb col…
2016
$R_{pPb}$ as a function of $p_{T}$ extracted from the invariant yields for six rapidity ranges, for eight centrality intervals, and for different geometrical models used to calculate $\langle T_{Pb} \rangle$.